Aging‐induced collateral impairment: role of arterial rarefaction, decreased eNOS expression/signaling, and increased susceptibility of endothelial cells to apoptosis
Epstein S, Wang J, Peng X, Zhuang Z, Simons M, Xue Z, Burnett M. Aging‐induced collateral impairment: role of arterial rarefaction, decreased eNOS expression/signaling, and increased susceptibility of endothelial cells to apoptosis. The FASEB Journal 2010, 24: 294.3-294.3. DOI: 10.1096/fasebj.24.1_supplement.294.3.Peer-Reviewed Original ResearchWild-type miceEndothelial cellsOld miceEndothelial nitric oxide synthase proteinNitric oxide synthase proteinOld wild-type micePositive animal studiesYoung wild-type miceENOS-KO miceENOS knockout miceDisappointing clinical resultsPre-existing arteriolesVessel phenotypeENOS expressionENOS proteinKO miceC57 miceClinical resultsYoung miceArteriolar rarefactionAge-induced changesKnockout miceAnimal studiesTherapeutic interventionsAngiogenesis therapy