2008
FGF mediates maintenance of vascular integrity in a Csk dependent manner
Murakami M, Zhuang Z, Moodie K, Stan R, Simons M. FGF mediates maintenance of vascular integrity in a Csk dependent manner. The FASEB Journal 2008, 22: 329.5-329.5. DOI: 10.1096/fasebj.22.1_supplement.329.5.Peer-Reviewed Original ResearchInhibition of FGFVE-cadherinVE-cadherin mutantCo-immunoprecipitation experimentsDominant-negative formCell-cell contactVE-cadherin complexVE-cadherin internalizationVE-cadherin stabilizationTotal expression levelsVascular integrityCSK associationFGF signalingP120-cateninEC monolayer permeabilitySrc activationChimera proteinTransgenic expressionFGF inhibitionFGFAdult vasculatureExpression levelsFGF-R1ProteinTie2 promoter
2006
The FGF system positively regulates vascular integrity after ischemic injury
Murakami M, Moodie K, Zhuang Z, Ko I, Stan R, Simons M. The FGF system positively regulates vascular integrity after ischemic injury. The FASEB Journal 2006, 20: a636-a636. DOI: 10.1096/fasebj.20.4.a636-b.Peer-Reviewed Original ResearchIschemic injuryFemoral arteryTen-week-old miceVascular integrityEndothelial cellsRight femoral arteryTissue cGMP levelsFemoral artery ligationGrowth factor systemFibroblast growth factor (FGF) systemRat femoral arteryConditional transgenic mouse lineTransgenic mouse lineFGF systemAortic endothelial cellsEndothelial barrier functionBovine aortic endothelial cellsIschemic sideArtery ligationVascular leakageHindlimb ischemiaOld miceIschemic regionCGMP levelsFoot loss