2007
Introductory Essay: Endothelial Cell Coupling
Simons M. Introductory Essay: Endothelial Cell Coupling. 2007, 627-631. DOI: 10.1017/cbo9780511546198.070.Peer-Reviewed Original ResearchSerine/threonine kinaseG protein-coupled receptorsEndothelial cellsTyrosine kinase receptorsAdhesion moleculesThreonine kinaseKinase receptorsEndothelial cell couplingExtracellular matrixSoluble ligandsTight junctionsGrowth factorCell couplingCellsEC interactionsCellular adhesion moleculesKinaseSyndecansReceptorsVessel wallIntegrinsMoleculesSolid phase environmentsBlood cellsAppropriate responseSyndecans
Tkachenko E, Rhodes J, Simons M. Syndecans. 2007, 396-402. DOI: 10.1017/cbo9780511546198.045.Peer-Reviewed Original ResearchSyndecan familyCore proteinExtracellular domainMembrane-anchored proteinsHeparan sulfateLarger heparan sulfateExtracellular matrix proteinsDifferent core proteinsCell surface receptorsSignaling inputsTransmembrane proteinSuch proteinsExtracellular proteinsDistinct functionsMatrix proteinsSyndecansProtein coreWide expressionSurface receptorsProteinGlycosaminoglycan chainsAttachment sitesRepeating disaccharide unitCS chainsTransmembrane
2006
Syndecan‐4 plays a key role in the phosphorylation of protein kinase B / Akt
Partovian C, Simons M. Syndecan‐4 plays a key role in the phosphorylation of protein kinase B / Akt. The FASEB Journal 2006, 20: a1080-a1080. DOI: 10.1096/fasebj.20.5.a1080-a.Peer-Reviewed Original ResearchPhosphoinositide-dependent kinase 1Syndecan-4Akt phosphorylationProtein kinase B/AktPhosphorylation of Thr308Hydrophobic motifActivation loopRaft fractionsEndothelial cellsKinase 1Akt activationPhosphorylationMammalian targetSyndecansThr308AktGrowth factorCentral roleRegulationCellsKey roleMajor roleRictorNumber of processesSer473