1999
Subxyphoid access of the normal pericardium: A novel drug delivery technique
Laham R, Simons M, Hung D. Subxyphoid access of the normal pericardium: A novel drug delivery technique. Catheterization And Cardiovascular Interventions 1999, 47: 109-111. PMID: 10385173, DOI: 10.1002/(sici)1522-726x(199905)47:1<109::aid-ccd24>3.0.co;2-3.Peer-Reviewed Original ResearchConceptsPericardial spaceHemodynamic compromiseNormal pericardiumSubxyphoid accessSmall pericardial effusionContinuous positive pressureNovel drug delivery techniqueIntrapericardial drug deliveryAnimals 4 weeksLarge animal modelDelivery techniquesNovel delivery techniquesAdverse eventsPericardial effusionMyocardial damageDrug delivery techniquesRight ventricleFluoroscopic guidanceInfusion catheterHistologic examinationPericardial accessIntroducer needlePositive pressureHigh riskAnimal models
1997
Macrophage-dependent regulation of syndecan gene expression.
Li J, Brown L, Laham R, Volk R, Simons M. Macrophage-dependent regulation of syndecan gene expression. Circulation Research 1997, 81: 785-96. PMID: 9351452, DOI: 10.1161/01.res.81.5.785.Peer-Reviewed Original ResearchConceptsBlood-derived macrophagesSyndecan expressionSyndecan geneMyocardial infarctionGene expressionRegulation of expressionSyndecan-1Op/op miceGranulocyte-macrophage colony-stimulating factorMacrophage colony-stimulating factorRat infarct modelColony-stimulating factorHeparin-binding growth factorsSyndecan-4 mRNASyndecan-1 mRNABiological processesMacrophage influxCellular responsesMacrophage contentSyndecan-4Right ventricleTissue injuryOp miceExtracellular matrixPrompt increase