2000
Efficacy of intracoronary versus intravenous FGF-2 in a pig model of chronic myocardial ischemia
Sato K, Laham R, Pearlman J, Novicki D, Sellke F, Simons M, Post M. Efficacy of intracoronary versus intravenous FGF-2 in a pig model of chronic myocardial ischemia. The Annals Of Thoracic Surgery 2000, 70: 2113-2118. PMID: 11156130, DOI: 10.1016/s0003-4975(00)02018-x.Peer-Reviewed Original ResearchConceptsChronic myocardial ischemiaRegional blood flowIschemic myocardiumFGF-2Myocardial ischemiaBlood flowPig modelML/min/Perfusion magnetic resonance imagingSingle intravenous infusionGrowth factor administrationRegional wall motionMagnetic resonance imagingAngiographic collateralsIntracoronary treatmentEjection fractionIntracoronary infusionIntravenous infusionIschemic areaFactor administrationMyocardial functionColored microspheresMyocardial perfusionResonance imagingTherapeutic angiogenesis
1995
Magnetic resonance mapping demonstrates benefits of VEGF–induced myocardial angiogenesis
Pearlman J, Hibberd M, Chuang M, Harada K, Lopez J, Gladstone S, Friedman M, Sellke F, Simons M. Magnetic resonance mapping demonstrates benefits of VEGF–induced myocardial angiogenesis. Nature Medicine 1995, 1: 1085-1089. PMID: 7489368, DOI: 10.1038/nm1095-1085.Peer-Reviewed Original ResearchConceptsVascular endothelial growth factorMagnetic resonance imagingBlood supplyCoronary occlusive diseasePlacebo-controlled studyCollateral blood supplyBetter ejection fractionCoronary artery occlusionCause of deathCollateral vessel developmentEndothelial growth factorRegional wall thickeningArtery occlusionOcclusive diseaseEjection fractionCollateral vesselsCoronary arteryCollateral developmentIschemic zoneVEGF infusionMyocardial angiogenesisResonance imagingWall thickeningHeart attackPorcine model