2003
Angiogenesis Therapies for Coronary Artery Disease
Simons M. Angiogenesis Therapies for Coronary Artery Disease. Methods In Pharmacology And Toxicology 2003, 0: 407-419. DOI: 10.1385/1-59259-404-2:407.Peer-Reviewed Original Research
2000
Clinical Trials in Coronary Angiogenesis: Issues, Problems, Consensus
Simons M, Bonow R, Chronos N, Cohen D, Giordano F, Hammond H, Laham R, Li W, Pike M, Sellke F, Stegmann T, Udelson J, Rosengart T. Clinical Trials in Coronary Angiogenesis: Issues, Problems, Consensus. Circulation 2000, 102: e73-86. PMID: 10982554, DOI: 10.1161/01.cir.102.11.e73.Peer-Reviewed Original ResearchMeSH KeywordsAngiogenesis Inducing AgentsAnimalsClinical Trials as TopicCoronary AngiographyCoronary VesselsEndothelial Growth FactorsFibroblast Growth Factor 2Genetic TherapyHeart DiseasesHumansLymphokinesMagnetic Resonance ImagingNeovascularization, PhysiologicPatient SelectionTomography, Emission-ComputedTomography, Emission-Computed, Single-PhotonVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsClinical trialsCoronary angiogenesisAdvanced ischemic heart diseaseAngiogenic growth factor therapySide effect profileIschemic heart diseaseGrowth factor therapyAppropriate patient populationAmerican Heart AssociationNew treatment strategiesTherapeutic end pointRoute of administrationBiology of angiogenesisNew blood supplyFactor therapyCoronary diseaseEffect profilePatient populationHeart AssociationHeart diseaseTreatment strategiesBlood supplyTherapeutic strategiesPreclinical investigationsTherapeutic angiogenesis
1999
Therapeutic Angiogenesis Using Basic Fibroblast Growth Factor and Vascular Endothelial Growth Factor Using Various Delivery Strategies.
Laham R, Garcia L, Baim D, Post M, Simons M. Therapeutic Angiogenesis Using Basic Fibroblast Growth Factor and Vascular Endothelial Growth Factor Using Various Delivery Strategies. Current Interventional Cardiology Reports 1999, 1: 228-233. PMID: 11096629.Peer-Reviewed Original ResearchVascular endothelial growth factorBasic fibroblast growth factorEndothelial growth factorGrowth factorFibroblast growth factorDouble-blind placebo-controlled trialIntravenous deliveryTherapeutic angiogenesisStandard revascularization proceduresPlacebo-controlled trialLarger patient populationChronic myocardial ischemiaDelivery strategiesPerivascular deliveryRevascularization proceduresPatient populationAtrial injectionIntrapericardial administrationTreatment modalitiesMyocardial ischemiaSustained administrationTreatment strategiesClinical studiesOutcome measuresIntramyocardial administration