2010
Aging‐induced collateral impairment: role of arterial rarefaction, decreased eNOS expression/signaling, and increased susceptibility of endothelial cells to apoptosis
Epstein S, Wang J, Peng X, Zhuang Z, Simons M, Xue Z, Burnett M. Aging‐induced collateral impairment: role of arterial rarefaction, decreased eNOS expression/signaling, and increased susceptibility of endothelial cells to apoptosis. The FASEB Journal 2010, 24: 294.3-294.3. DOI: 10.1096/fasebj.24.1_supplement.294.3.Peer-Reviewed Original ResearchWild-type miceEndothelial cellsOld miceEndothelial nitric oxide synthase proteinNitric oxide synthase proteinOld wild-type micePositive animal studiesYoung wild-type miceENOS-KO miceENOS knockout miceDisappointing clinical resultsPre-existing arteriolesVessel phenotypeENOS expressionENOS proteinKO miceC57 miceClinical resultsYoung miceArteriolar rarefactionAge-induced changesKnockout miceAnimal studiesTherapeutic interventionsAngiogenesis therapy
2006
The FGF system positively regulates vascular integrity after ischemic injury
Murakami M, Moodie K, Zhuang Z, Ko I, Stan R, Simons M. The FGF system positively regulates vascular integrity after ischemic injury. The FASEB Journal 2006, 20: a636-a636. DOI: 10.1096/fasebj.20.4.a636-b.Peer-Reviewed Original ResearchIschemic injuryFemoral arteryTen-week-old miceVascular integrityEndothelial cellsRight femoral arteryTissue cGMP levelsFemoral artery ligationGrowth factor systemFibroblast growth factor (FGF) systemRat femoral arteryConditional transgenic mouse lineTransgenic mouse lineFGF systemAortic endothelial cellsEndothelial barrier functionBovine aortic endothelial cellsIschemic sideArtery ligationVascular leakageHindlimb ischemiaOld miceIschemic regionCGMP levelsFoot loss