2007
Introductory Essay: Endothelial Cell Coupling
Simons M. Introductory Essay: Endothelial Cell Coupling. 2007, 627-631. DOI: 10.1017/cbo9780511546198.070.Peer-Reviewed Original ResearchSerine/threonine kinaseG protein-coupled receptorsEndothelial cellsTyrosine kinase receptorsAdhesion moleculesThreonine kinaseKinase receptorsEndothelial cell couplingExtracellular matrixSoluble ligandsTight junctionsGrowth factorCell couplingCellsEC interactionsCellular adhesion moleculesKinaseSyndecansReceptorsVessel wallIntegrinsMoleculesSolid phase environmentsBlood cellsAppropriate responseSynectin‐dependent suppression of basal Rac1 activity is reversed by a signaling pathway involving PKCalpha and RhoG
Elfenbein A, Simons M. Synectin‐dependent suppression of basal Rac1 activity is reversed by a signaling pathway involving PKCalpha and RhoG. The FASEB Journal 2007, 21: lb11-lb12. DOI: 10.1096/fasebj.21.6.lb11-d.Peer-Reviewed Original ResearchFibroblast growth factorEndothelial cellsHigh-affinity tyrosine kinase receptorsLow baseline levelsRac1 activitySerum-starved endothelial cellsHigh-affinity receptorTyrosine kinase receptorsBaseline levelsGrowth factorInhibitor-1Endothelial cell migrationHeparan sulfate proteoglycanDissociation inhibitor 1Kinase receptorsMigratory responseEarly eventsNovel roleSulfate proteoglycanCell migration
2001
Syndecan-4-mediated signalling
Simons M, Horowitz A. Syndecan-4-mediated signalling. Cellular Signalling 2001, 13: 855-862. PMID: 11728825, DOI: 10.1016/s0898-6568(01)00190-5.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsFibroblast Growth FactorsIsoenzymesMacromolecular SubstancesMembrane GlycoproteinsModels, BiologicalMolecular Sequence DataPhosphatidylinositol 4,5-DiphosphatePhosphorylationProtein Kinase CProtein Kinase C-alphaProtein Structure, TertiaryProteoglycansSignal TransductionSyndecan-4ConceptsSyndecan familySyndecan-4Carboxy-terminal PDZPDZ adaptor proteinsUnique signaling functionsProtein kinase C alphaCore proteinExtracellular matrix proteinsHeparan sulfate chainsSoluble growth factorsTyrosine kinase receptorsAdaptor proteinCytoplasmic tailSignaling functionsTransmembrane proteoglycansProteoglycan functionMultimolecular complexesC alphaMatrix proteinsKinase receptorsPostsynaptic density-95Zona occludensGlycosaminoglycan chainsSulfate chainsProtein