2001
Serial Motion Assessment by Reference Tracking (SMART): Application to Detection of Local Functional Impact of Chronic Myocardial Ischemia
Pearlman J, Gertz Z, Wu Y, Simons M, Post M. Serial Motion Assessment by Reference Tracking (SMART): Application to Detection of Local Functional Impact of Chronic Myocardial Ischemia. Journal Of Computer Assisted Tomography 2001, 25: 558-562. PMID: 11473185, DOI: 10.1097/00004728-200107000-00008.Peer-Reviewed Original Research
2000
Intracoronary basic fibroblast growth factor (FGF-2) in patients with severe ischemic heart disease: results of a Phase I open-label dose escalation study
Laham R, Chronos N, Pike M, Leimbach M, Udelson J, Pearlman J, Pettigrew R, Whitehouse MJ, Yoshizawa C, Simons M. Intracoronary basic fibroblast growth factor (FGF-2) in patients with severe ischemic heart disease: results of a Phase I open-label dose escalation study. Journal Of The American College Of Cardiology 2000, 36: 2132-2139. PMID: 11127452, DOI: 10.1016/s0735-1097(00)00988-8.Peer-Reviewed Original ResearchConceptsIntracoronary basic fibroblast growth factorOpen-label dose-escalation studyDose-escalation studyIschemic heart diseaseBasic fibroblast growth factorFibroblast growth factorHeart diseaseGrowth factorPhase I open-label dose-escalation studyFGF-2Non-Q-wave myocardial infarctionSevere ischemic heart diseaseSeattle Angina QuestionnaireTreadmill exercise testingQuality of lifeRegional wall thickeningMagnetic resonance imagingRFGF-2Angina QuestionnaireExercise toleranceRetinal examinationEscalation studyExercise testingIntracoronary administrationLaboratory parametersClinical Trials in Coronary Angiogenesis: Issues, Problems, Consensus
Simons M, Bonow R, Chronos N, Cohen D, Giordano F, Hammond H, Laham R, Li W, Pike M, Sellke F, Stegmann T, Udelson J, Rosengart T. Clinical Trials in Coronary Angiogenesis: Issues, Problems, Consensus. Circulation 2000, 102: e73-86. PMID: 10982554, DOI: 10.1161/01.cir.102.11.e73.Peer-Reviewed Original ResearchMeSH KeywordsAngiogenesis Inducing AgentsAnimalsClinical Trials as TopicCoronary AngiographyCoronary VesselsEndothelial Growth FactorsFibroblast Growth Factor 2Genetic TherapyHeart DiseasesHumansLymphokinesMagnetic Resonance ImagingNeovascularization, PhysiologicPatient SelectionTomography, Emission-ComputedTomography, Emission-Computed, Single-PhotonVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsClinical trialsCoronary angiogenesisAdvanced ischemic heart diseaseAngiogenic growth factor therapySide effect profileIschemic heart diseaseGrowth factor therapyAppropriate patient populationAmerican Heart AssociationNew treatment strategiesTherapeutic end pointRoute of administrationBiology of angiogenesisNew blood supplyFactor therapyCoronary diseaseEffect profilePatient populationHeart AssociationHeart diseaseTreatment strategiesBlood supplyTherapeutic strategiesPreclinical investigationsTherapeutic angiogenesisTherapeutic Angiogenesis Using Local Perivascular and Pericardial Delivery.
Laham R, Post M, Sellke F, Simons M. Therapeutic Angiogenesis Using Local Perivascular and Pericardial Delivery. Current Interventional Cardiology Reports 2000, 2: 213-217. PMID: 11096670.Peer-Reviewed Original ResearchIschemic heart diseaseTherapeutic angiogenesisHeart diseaseCoronary artery bypass surgeryPericardial deliveryPotential new treatment strategyLocal perivascular deliveryArtery bypass surgeryNew treatment strategiesGrowth factor-induced angiogenesisClinical therapeutic angiogenesisNew blood vesselsBypass surgeryPerivascular deliveryIschemic myocardiumEpicardial vesselsTreatment strategiesAngiogenic cytokinesTheoretic advantagesSustained exposureBlood vesselsAngiogenesisDelivery modalitiesLimited dataPoor understanding
1999
Therapeutic Angiogenesis Using Endocardial Approach to Administration: Techniques and Results.
Garcia L, Baim D, Post M, Simons M, Laham R. Therapeutic Angiogenesis Using Endocardial Approach to Administration: Techniques and Results. Current Interventional Cardiology Reports 1999, 1: 222-227. PMID: 11096628.Peer-Reviewed Original ResearchTherapeutic angiogenesisClinical trialsClinical studiesPreclinical studiesSurgical accessSerious systemic adverse eventsSystemic adverse eventsIschemic heart diseaseMost clinical trialsChronic myocardial ischemiaThree-dimensional navigation systemMost preclinical studiesDelivery strategiesAngiogenic growth factorsAdverse eventsLocal therapyGeneral anesthesiaMyocardial ischemiaHeart diseaseFluoroscopic guidanceClinical usefulnessEndocardial approachSystemic recirculationAnimal modelsDelivery catheter
1998
Local perivascular basic fibroblast growth factor (bFGF) treatment in patients with ischemic heart disease
Laham R, Sellke F, Edelman E, Pearlman J, Simons M. Local perivascular basic fibroblast growth factor (bFGF) treatment in patients with ischemic heart disease. Journal Of The American College Of Cardiology 1998, 31: 394. DOI: 10.1016/s0735-1097(98)80061-2.Peer-Reviewed Original Research
1997
Angiogenesis in ischemic heart disease
Ware J, Simons M. Angiogenesis in ischemic heart disease. Nature Medicine 1997, 3: 158-164. PMID: 9018233, DOI: 10.1038/nm0297-158.Peer-Reviewed Original Research