2000
Synectin, syndecan‐4 cytoplasmic domain binding PDZ protein, inhibits cell migration
Gao Y, Li M, Chen W, Simons M. Synectin, syndecan‐4 cytoplasmic domain binding PDZ protein, inhibits cell migration. Journal Of Cellular Physiology 2000, 184: 373-379. PMID: 10911369, DOI: 10.1002/1097-4652(200009)184:3<373::aid-jcp12>3.0.co;2-i.Peer-Reviewed Original ResearchConceptsSyndecan-4Cytoplasmic domainSyndecan-4 cytoplasmic domainTwo-hybrid libraryDomain-mediated interactionsNovel binding partnerInhibits cell migrationGene familyPDZ proteinsBinding partnerDependent regulationSynectinImportant regulatorCell adhesionCell migrationCell growthGrowth rateGIPCMigrationRegulatorDomainProteinTransportersOverexpressionNeuropilins
1999
Myocyte-dependent Regulation of Endothelial Cell Syndecan-4 Expression ROLE OF TNF-α*
Zhang Y, Pasparakis M, Kollias G, Simons M. Myocyte-dependent Regulation of Endothelial Cell Syndecan-4 Expression ROLE OF TNF-α*. Journal Of Biological Chemistry 1999, 274: 14786-14790. PMID: 10329676, DOI: 10.1074/jbc.274.21.14786.Peer-Reviewed Original ResearchConceptsSyndecan-4 expressionECV cellsProtein kinase C alphaCardiac myocytesGene familySyndecan-4 mRNATNF-alphaPosttranscriptional mechanismsGene expressionPrimary cardiac myocytesUnique memberC alphaHuman endothelial cellsSyndecan-4Western analysisMouse cardiac myocytesSyndecan-4 levelsNormal myoblastsDependent mannerNF-kappaBExpressionH9c2 cellsHypoxic conditionsTumor necrosisEndothelial cells
1993
Fractal landscapes and molecular evolution: modeling the myosin heavy chain gene family
Buldyrev S, Goldberger A, Havlin S, Peng C, Stanley H, Stanley M, Simons M. Fractal landscapes and molecular evolution: modeling the myosin heavy chain gene family. Biophysical Journal 1993, 65: 2673-2679. PMID: 8312501, PMCID: PMC1226007, DOI: 10.1016/s0006-3495(93)81290-6.Peer-Reviewed Original ResearchConceptsMyosin heavy chain gene familyHeavy chain gene familyIntrons-late theoryMyosin heavy chain sequencesGene evolutionMolecular evolutionGene familyNucleotide sequenceMHC genesDifferent speciesDNA walksHeavy chain sequencesFractal landscapesSequenceChain sequencesVertebratesYeastGenesEvolutionSpeciesDNALandscape analysisSimple iterative modelPolymeric sequencesFamily