Therapeutic Angiogenesis Using Endocardial Approach to Administration: Techniques and Results.
Garcia L, Baim D, Post M, Simons M, Laham R. Therapeutic Angiogenesis Using Endocardial Approach to Administration: Techniques and Results. Current Interventional Cardiology Reports 1999, 1: 222-227. PMID: 11096628.Peer-Reviewed Original ResearchTherapeutic angiogenesisClinical trialsClinical studiesPreclinical studiesSurgical accessSerious systemic adverse eventsSystemic adverse eventsIschemic heart diseaseMost clinical trialsChronic myocardial ischemiaThree-dimensional navigation systemMost preclinical studiesDelivery strategiesAngiogenic growth factorsAdverse eventsLocal therapyGeneral anesthesiaMyocardial ischemiaHeart diseaseFluoroscopic guidanceClinical usefulnessEndocardial approachSystemic recirculationAnimal modelsDelivery catheterSubxyphoid access of the normal pericardium: A novel drug delivery technique
Laham R, Simons M, Hung D. Subxyphoid access of the normal pericardium: A novel drug delivery technique. Catheterization And Cardiovascular Interventions 1999, 47: 109-111. PMID: 10385173, DOI: 10.1002/(sici)1522-726x(199905)47:1<109::aid-ccd24>3.0.co;2-3.Peer-Reviewed Original ResearchConceptsPericardial spaceHemodynamic compromiseNormal pericardiumSubxyphoid accessSmall pericardial effusionContinuous positive pressureNovel drug delivery techniqueIntrapericardial drug deliveryAnimals 4 weeksLarge animal modelDelivery techniquesNovel delivery techniquesAdverse eventsPericardial effusionMyocardial damageDrug delivery techniquesRight ventricleFluoroscopic guidanceInfusion catheterHistologic examinationPericardial accessIntroducer needlePositive pressureHigh riskAnimal models