2023
Acetate controls endothelial-to-mesenchymal transition
Zhu X, Wang Y, Soaita I, Lee H, Bae H, Boutagy N, Bostwick A, Zhang R, Bowman C, Xu Y, Trefely S, Chen Y, Qin L, Sessa W, Tellides G, Jang C, Snyder N, Yu L, Arany Z, Simons M. Acetate controls endothelial-to-mesenchymal transition. Cell Metabolism 2023, 35: 1163-1178.e10. PMID: 37327791, PMCID: PMC10529701, DOI: 10.1016/j.cmet.2023.05.010.Peer-Reviewed Original ResearchConceptsTGF-β signalingChronic vascular diseaseTGF-β receptor ALK5Mesenchymal transitionInduction of EndMTVascular diseaseMolecular basisPositive feedback loopReceptor ALK5Cellular levelSMADs 2Novel targetEndMT inductionMetabolic modulationMetabolic basisFibrotic stateSignalingPotential treatmentEndMTTGFDiseaseActivationInductionACSS2PDK4
2008
Journeys in Coronary Angiogenesis
Paye J, Partovian C, Simons M. Journeys in Coronary Angiogenesis. 2008, 561-573. DOI: 10.1007/978-0-387-71518-6_47.Peer-Reviewed Original ResearchYoung animal modelsPotential therapeutic avenuesCoronary collateralsCoronary diseaseArterial occlusionCoronary vascular developmentClinical trialsCoronary angiogenesisIschemic tissueBlood flowExogenous growth factorsAnimal modelsTherapeutic neovascularizationTherapeutic avenuesGrowth factorVessel developmentVascular developmentBasic sciencePatientsBypassNeovascularizationDiseaseTrialsOcclusion
2003
Angiogenesis Therapies for Coronary Artery Disease
Simons M. Angiogenesis Therapies for Coronary Artery Disease. Methods In Pharmacology And Toxicology 2003, 0: 407-419. DOI: 10.1385/1-59259-404-2:407.Peer-Reviewed Original Research
2001
GENE TRANSFER FOR ANGIOGENESIS IN CORONARY ARTERY DISEASE
Laham R, Simons M, Sellke F. GENE TRANSFER FOR ANGIOGENESIS IN CORONARY ARTERY DISEASE. Annual Review Of Medicine 2001, 52: 485-502. PMID: 11160791, DOI: 10.1146/annurev.med.52.1.485.Peer-Reviewed Original ResearchConceptsPromising novel therapeutic strategyAvailable preclinical dataStandard revascularization strategyPeripheral vascular diseaseCoronary artery diseasePreliminary clinical experienceNovel therapeutic strategiesCell-based vectorsRevascularization strategyArtery diseasePreclinical dataVascular diseaseClinical trialsIschemic heartBlood flowTherapeutic strategiesClinical experienceTherapeutic angiogenesisAngiogenesisDelivery modalitiesGene transfer studiesDiseaseGene transfer vectorsPreliminary naturePatients
1999
Angiogenesis in Cardiovascular Disease
Sellke F, Simons M. Angiogenesis in Cardiovascular Disease. Drugs 1999, 58: 391-396. PMID: 10493268, DOI: 10.2165/00003495-199958030-00001.Peer-Reviewed Original ResearchConceptsInoperable coronary artery diseaseTherapeutic angiogenesisChronic myocardial ischaemiaCoronary artery diseasePreliminary clinical trialsAngiogenic growth factorsMyocardial revascularisationArtery diseaseMyocardial ischaemiaTreatment optionsGrowth factor proteinClinical trialsCardiovascular diseaseMyocardial perfusionProtein administrationAnimal modelsAngiogenic factorsObjective evidenceGrowth factorAngiogenesisPatientsDiseaseAdministrationGene therapyOptimal candidates
1998
Local perivascular basic fibroblast growth factor (bFGF) treatment in patients with ischemic heart disease
Laham R, Sellke F, Edelman E, Pearlman J, Simons M. Local perivascular basic fibroblast growth factor (bFGF) treatment in patients with ischemic heart disease. Journal Of The American College Of Cardiology 1998, 31: 394. DOI: 10.1016/s0735-1097(98)80061-2.Peer-Reviewed Original Research
1997
Angiogenesis in ischemic heart disease
Ware J, Simons M. Angiogenesis in ischemic heart disease. Nature Medicine 1997, 3: 158-164. PMID: 9018233, DOI: 10.1038/nm0297-158.Peer-Reviewed Original Research
1994
The impact of clinical data on interpretation of thallium scintigrams
Simons M, Parker J, Donohoe K, Udelson J, Gervino E. The impact of clinical data on interpretation of thallium scintigrams. Journal Of Nuclear Cardiology 1994, 1: 365-371. PMID: 9420719, DOI: 10.1007/bf02939957.Peer-Reviewed Original ResearchConceptsClinical dataClinical informationCoronary diseaseThallium scansExercise thallium scanThallium lung uptakeCoronary artery diseaseArtery diseaseVentricular dilationLung uptakeThallium scintigramsPerfusion abnormalitiesDiagnostic imaging informationClinical managementScintigraphic dataPatientsCliniciansDiseaseTest scoresScoresScansOverall test scoresImaging informationRadiologistsScintigrams
1991
Assessement of restenosis vs primary lesions in patients with peripheral vascular disease using in situ hybridization and gene expression of two nonmuscle myosin isoforms
Leclerc G, Weir L, Simons M, Kearney M, Rosenfield K, Isner J. Assessement of restenosis vs primary lesions in patients with peripheral vascular disease using in situ hybridization and gene expression of two nonmuscle myosin isoforms. Journal Of The American College Of Cardiology 1991, 17: a105. DOI: 10.1016/0735-1097(91)91387-t.Peer-Reviewed Original Research