2007
THE ANTI‐ANGIOGENIC ACTIVITY OF rPAI‐123 INHIBITS ANGIOGENIC VASA VASORUM AND ATHERSCLEROTIC PLAQUE GROWTH
Mulligan‐Kehoe M, Drinane M, Mollmark J, Simons M. THE ANTI‐ANGIOGENIC ACTIVITY OF rPAI‐123 INHIBITS ANGIOGENIC VASA VASORUM AND ATHERSCLEROTIC PLAQUE GROWTH. The FASEB Journal 2007, 21: a16-a17. DOI: 10.1096/fasebj.21.5.a16-d.Peer-Reviewed Original ResearchHigh-fat dietAnti-angiogenic activityVasa vasorumPlaque growthSaline treatmentPlaque areaPlaque progressionLumen areaRole of angiogenesisVasa vasorum densitySignificant anti-angiogenic activityAtherogenic micePlaque regressionHFD groupNeovascularized areaChow dietPAI-1 proteinFat dietAortic rootControl animalsVessel circumferenceVasorumVessel areaMiceReconstructed vessels
1996
Local Extravascular Growth Factor Delivery in Myocardial Ischemia
Lopez J, Simons M. Local Extravascular Growth Factor Delivery in Myocardial Ischemia. Drug Delivery 1996, 3: 143-147. PMID: 26790909, DOI: 10.3109/10717549609029443.Peer-Reviewed Original ResearchBasic fibroblast growth factorVascular endothelial growth factorIschemic myocardiumGrowth factorCoronary collateral circulationNumber of microvesselsNon-ischemic myocardiumImplantable osmotic pumpMyocardial blood flowPerivascular drug deliveryEndothelial growth factorAngiogenic growth factorsFibroblast growth factorCollateral circulationChronic ischemiaMyocardial performanceMyocardial ischemiaVEGF administrationHeart sectionsBlood flowControl animalsMyocardial perfusionOsmotic pumpControl groupExogenous growth factor delivery