2001
Syndecan-4-mediated signalling
Simons M, Horowitz A. Syndecan-4-mediated signalling. Cellular Signalling 2001, 13: 855-862. PMID: 11728825, DOI: 10.1016/s0898-6568(01)00190-5.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsFibroblast Growth FactorsIsoenzymesMacromolecular SubstancesMembrane GlycoproteinsModels, BiologicalMolecular Sequence DataPhosphatidylinositol 4,5-DiphosphatePhosphorylationProtein Kinase CProtein Kinase C-alphaProtein Structure, TertiaryProteoglycansSignal TransductionSyndecan-4ConceptsSyndecan familySyndecan-4Carboxy-terminal PDZPDZ adaptor proteinsUnique signaling functionsProtein kinase C alphaCore proteinExtracellular matrix proteinsHeparan sulfate chainsSoluble growth factorsTyrosine kinase receptorsAdaptor proteinCytoplasmic tailSignaling functionsTransmembrane proteoglycansProteoglycan functionMultimolecular complexesC alphaMatrix proteinsKinase receptorsPostsynaptic density-95Zona occludensGlycosaminoglycan chainsSulfate chainsProtein
1999
Myocyte-dependent Regulation of Endothelial Cell Syndecan-4 Expression ROLE OF TNF-α*
Zhang Y, Pasparakis M, Kollias G, Simons M. Myocyte-dependent Regulation of Endothelial Cell Syndecan-4 Expression ROLE OF TNF-α*. Journal Of Biological Chemistry 1999, 274: 14786-14790. PMID: 10329676, DOI: 10.1074/jbc.274.21.14786.Peer-Reviewed Original ResearchConceptsSyndecan-4 expressionECV cellsProtein kinase C alphaCardiac myocytesGene familySyndecan-4 mRNATNF-alphaPosttranscriptional mechanismsGene expressionPrimary cardiac myocytesUnique memberC alphaHuman endothelial cellsSyndecan-4Western analysisMouse cardiac myocytesSyndecan-4 levelsNormal myoblastsDependent mannerNF-kappaBExpressionH9c2 cellsHypoxic conditionsTumor necrosisEndothelial cells