2008
Journeys in Coronary Angiogenesis
Paye J, Partovian C, Simons M. Journeys in Coronary Angiogenesis. 2008, 561-573. DOI: 10.1007/978-0-387-71518-6_47.Peer-Reviewed Original ResearchYoung animal modelsPotential therapeutic avenuesCoronary collateralsCoronary diseaseArterial occlusionCoronary vascular developmentClinical trialsCoronary angiogenesisIschemic tissueBlood flowExogenous growth factorsAnimal modelsTherapeutic neovascularizationTherapeutic avenuesGrowth factorVessel developmentVascular developmentBasic sciencePatientsBypassNeovascularizationDiseaseTrialsOcclusion
2000
Therapeutic Angiogenesis
Simons M, Laham R, Post M, Sellke F. Therapeutic Angiogenesis. BioDrugs 2000, 14: 13-20. PMID: 18034552, DOI: 10.2165/00063030-200014010-00002.Peer-Reviewed Original ResearchGrowth factorTherapeutic angiogenesisAdvanced coronary diseaseAdverse effect profileInitial clinical dataRecent clinical experienceBasic fibroblast growth factorQuality of lifeAngiogenic growth factorsFibroblast growth factorCoronary diseaseEffect profileClinical dataPreclinical studiesAnimal modelsClinical experienceNew vasculatureClinical applicationPractical clinical applicationsAngiogenesisBFGFBasic biologyPatientsFactorsSymptomsEffect of Intracoronary Recombinant Human Vascular Endothelial Growth Factor on Myocardial Perfusion
Hendel R, Henry T, Rocha-Singh K, Isner J, Kereiakes D, Giordano F, Simons M, Bonow R. Effect of Intracoronary Recombinant Human Vascular Endothelial Growth Factor on Myocardial Perfusion. Circulation 2000, 101: 118-121. PMID: 10637195, DOI: 10.1161/01.cir.101.2.118.Peer-Reviewed Original ResearchMeSH KeywordsCardiotonic AgentsCoronary CirculationCoronary DiseaseCoronary VesselsDipyridamoleDobutamineDose-Response Relationship, DrugDouble-Blind MethodEndothelial Growth FactorsExercise TestHumansInjections, Intra-ArterialLymphokinesRecombinant ProteinsTomography, Emission-Computed, Single-PhotonVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsVasodilator AgentsConceptsRecombinant human vascular endothelial growth factorSingle-photon emission CTVascular endothelial growth factorEndothelial growth factorMyocardial perfusionStress scoresHuman vascular endothelial growth factorGrowth factorPerfusion single-photon emission CTDose-dependent effectPhoton emission CTMyocardial perfusion single photon emission CTCoronary revascularizationRest scorePhase 1 dataAnimal modelsPatientsEmission CTLow dosesTherapeutic angiogenesisVisual findingsPerfusionStatistical significanceClinical applicationScores
1999
Angiogenesis in Cardiovascular Disease
Sellke F, Simons M. Angiogenesis in Cardiovascular Disease. Drugs 1999, 58: 391-396. PMID: 10493268, DOI: 10.2165/00003495-199958030-00001.Peer-Reviewed Original ResearchConceptsInoperable coronary artery diseaseTherapeutic angiogenesisChronic myocardial ischaemiaCoronary artery diseasePreliminary clinical trialsAngiogenic growth factorsMyocardial revascularisationArtery diseaseMyocardial ischaemiaTreatment optionsGrowth factor proteinClinical trialsCardiovascular diseaseMyocardial perfusionProtein administrationAnimal modelsAngiogenic factorsObjective evidenceGrowth factorAngiogenesisPatientsDiseaseAdministrationGene therapyOptimal candidatesTherapeutic Angiogenesis Using Endocardial Approach to Administration: Techniques and Results.
Garcia L, Baim D, Post M, Simons M, Laham R. Therapeutic Angiogenesis Using Endocardial Approach to Administration: Techniques and Results. Current Interventional Cardiology Reports 1999, 1: 222-227. PMID: 11096628.Peer-Reviewed Original ResearchTherapeutic angiogenesisClinical trialsClinical studiesPreclinical studiesSurgical accessSerious systemic adverse eventsSystemic adverse eventsIschemic heart diseaseMost clinical trialsChronic myocardial ischemiaThree-dimensional navigation systemMost preclinical studiesDelivery strategiesAngiogenic growth factorsAdverse eventsLocal therapyGeneral anesthesiaMyocardial ischemiaHeart diseaseFluoroscopic guidanceClinical usefulnessEndocardial approachSystemic recirculationAnimal modelsDelivery catheterSubxyphoid access of the normal pericardium: A novel drug delivery technique
Laham R, Simons M, Hung D. Subxyphoid access of the normal pericardium: A novel drug delivery technique. Catheterization And Cardiovascular Interventions 1999, 47: 109-111. PMID: 10385173, DOI: 10.1002/(sici)1522-726x(199905)47:1<109::aid-ccd24>3.0.co;2-3.Peer-Reviewed Original ResearchConceptsPericardial spaceHemodynamic compromiseNormal pericardiumSubxyphoid accessSmall pericardial effusionContinuous positive pressureNovel drug delivery techniqueIntrapericardial drug deliveryAnimals 4 weeksLarge animal modelDelivery techniquesNovel delivery techniquesAdverse eventsPericardial effusionMyocardial damageDrug delivery techniquesRight ventricleFluoroscopic guidanceInfusion catheterHistologic examinationPericardial accessIntroducer needlePositive pressureHigh riskAnimal models