2002
A1 adenosine receptor activation induces ventriculomegaly and white matter loss
Turner CP, Yan H, Schwartz M, Othman T, Rivkees SA. A1 adenosine receptor activation induces ventriculomegaly and white matter loss. Neuroreport 2002, 13: 1199-1204. PMID: 12151769, DOI: 10.1097/00001756-200207020-00026.Peer-Reviewed Original ResearchMeSH KeywordsAdenosineAnimalsAnimals, NewbornBody WeightCell CountCerebral CortexCerebral VentriclesDrug CombinationsDrug InteractionsGTP-Binding ProteinsGuanosine 5'-O-(3-Thiotriphosphate)HippocampusMicroscopy, ElectronMyelin Basic ProteinNerve DegenerationNerve Fibers, MyelinatedNeurogliaNeuronsPresynaptic TerminalsPurinergic P1 Receptor AgonistsPurinergic P1 Receptor AntagonistsRatsRats, Sprague-DawleyReceptors, Purinergic P1TelencephalonTheophyllineConceptsWhite matter lossAdenosine receptor activationActivation of A1ARPostnatal day 3White matter volumeReceptor-G protein couplingMyelin basic proteinNeuronal lossAgonist treatmentNeonatal ratsN6-cyclopentyladenosineA1AR activationMatter volumeDay 3Adenosine receptorsReceptor activationBrain formationPD 4A1ARReduced expressionProtein couplingQuantitative electron microscopyVentriculomegalyBasic proteinBrain
2000
Basic Fibroblast Growth Factor (Fgf2) Is Necessary for Cell Proliferation and Neurogenesis in the Developing Cerebral Cortex
Raballo R, Rhee J, Lyn-Cook R, Leckman J, Schwartz M, Vaccarino F. Basic Fibroblast Growth Factor (Fgf2) Is Necessary for Cell Proliferation and Neurogenesis in the Developing Cerebral Cortex. Journal Of Neuroscience 2000, 20: 5012-5023. PMID: 10864959, PMCID: PMC6772267, DOI: 10.1523/jneurosci.20-13-05012.2000.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCell DivisionCerebral CortexChoroid PlexusEmbryonic and Fetal DevelopmentFibroblast Growth Factor 2Gene Expression Regulation, DevelopmentalGerm-Line MutationGestational AgeMiceMice, KnockoutProsencephalonReceptor Protein-Tyrosine KinasesReceptor, Fibroblast Growth Factor, Type 1Receptors, Fibroblast Growth FactorTelencephalonConceptsFgf2 knockout micePseudostratified ventricular epitheliumKnockout miceCerebral cortexCortical neuronsFrontal cerebral cortexDeep cortical layersBasic fibroblast growth factorEnd of neurogenesisCortical neuron numberNeuronal progenitor cellsNull mutant miceBasic fibroblast growth factor (bFGF) geneFibroblast growth factorDegree of apoptosisLarge neuronsBasal gangliaCortical layersFgf2 knockoutGrowth factor geneMutant miceVentricular epitheliumGermline mutationsNeuron numberNeurogenesis