Association of Variants of Arginine Vasopressin and Arginine Vasopressin Receptor 1A With Severe Acetaminophen Liver Injury
Randesi M, Levran O, da Rosa J, Hankins J, Rule J, Kreek M, Lee W, Group A, Reuben A, Fontana R, Davern T, McGuire B, Stravitz R, Durkalski V, Liou I, Fix O, Schilsky M, Ganger D, Chung R, Koch D, Reddy K, Rossaro L. Association of Variants of Arginine Vasopressin and Arginine Vasopressin Receptor 1A With Severe Acetaminophen Liver Injury. Cellular And Molecular Gastroenterology And Hepatology 2017, 3: 500-505. PMID: 28462386, PMCID: PMC5404026, DOI: 10.1016/j.jcmgh.2017.01.008.Peer-Reviewed Original ResearchLiver injurySingle nucleotide polymorphismsUse disordersDrug use disorder diagnosisTertiary care liver centreStress responsivityAltered stress responsivityLiver failure resultsAcute liver injuryDrug use disordersGenotype frequenciesConcomitant alcohol abuseSubstance use disordersHigh-risk behaviorsHealthy white controlsDrugs of abuseAssociation of variantsLiver centersOpioid useWhite patientsMean ageAcetaminophen toxicityAlcohol abuseStudy subjectsArginine vasopressin