2021
Coagulopathy, Bleeding Events, and Outcome According to Rotational Thromboelastometry in Patients With Acute Liver Injury/Failure
Stravitz RT, Fontana RJ, Meinzer C, Durkalski‐Mauldin V, Hanje AJ, Olson J, Koch D, Hamid B, Schilsky M, McGuire B, Ganger D, Liou I, Karvellas CJ, Rule JA, Lisman T, Clasen K, Reuben A, Cripps M, Lee WM, Group A. Coagulopathy, Bleeding Events, and Outcome According to Rotational Thromboelastometry in Patients With Acute Liver Injury/Failure. Hepatology 2021, 74: 937-949. PMID: 33636020, PMCID: PMC10668528, DOI: 10.1002/hep.31767.Peer-Reviewed Original ResearchConceptsALI/ALFROTEM parametersRotational thromboelastometryDisease severityAcute liver injury/failureAbnormal hemostatic profileSevere systemic complicationsAcute liver injuryBleeding eventsBleeding riskLiver transplantationSystemic complicationsHemostatic failureLiver injuryIllness severityNative liverAbnormal hemostasisHemostatic profileStudy groupHigh incidencePatientsNormal rangeLaboratory evidenceClot formationClot stability
2017
Association of Variants of Arginine Vasopressin and Arginine Vasopressin Receptor 1A With Severe Acetaminophen Liver Injury
Randesi M, Levran O, da Rosa J, Hankins J, Rule J, Kreek M, Lee W, Group A, Reuben A, Fontana R, Davern T, McGuire B, Stravitz R, Durkalski V, Liou I, Fix O, Schilsky M, Ganger D, Chung R, Koch D, Reddy K, Rossaro L. Association of Variants of Arginine Vasopressin and Arginine Vasopressin Receptor 1A With Severe Acetaminophen Liver Injury. Cellular And Molecular Gastroenterology And Hepatology 2017, 3: 500-505. PMID: 28462386, PMCID: PMC5404026, DOI: 10.1016/j.jcmgh.2017.01.008.Peer-Reviewed Original ResearchLiver injurySingle nucleotide polymorphismsUse disordersDrug use disorder diagnosisTertiary care liver centreStress responsivityAltered stress responsivityLiver failure resultsAcute liver injuryDrug use disordersGenotype frequenciesConcomitant alcohol abuseSubstance use disordersHigh-risk behaviorsHealthy white controlsDrugs of abuseAssociation of variantsLiver centersOpioid useWhite patientsMean ageAcetaminophen toxicityAlcohol abuseStudy subjectsArginine vasopressin
2009
ICU Management of Acute Liver Failure
Schilsky ML, Honiden S, Arnott L, Emre S. ICU Management of Acute Liver Failure. Clinics In Chest Medicine 2009, 30: 71-87. PMID: 19186281, DOI: 10.1016/j.ccm.2008.10.001.Peer-Reviewed Original ResearchConceptsAcute liver failureLiver failureTeam approachGood ICU careOrganized team approachAcute liver injurySurvival of patientsBetter patient outcomesEarly disease recognitionLiver transplantationICU careLiver injuryICU managementPatient outcomesCritical carePatient managementSupportive measuresPatientsCareDisease recognitionICUTransplantationFailurePathophysiologyInjury