2016
Presynaptic GABA Receptors Mediate Temporal Contrast Enhancement in Drosophila Olfactory Sensory Neurons and Modulate Odor-Driven Behavioral Kinetics
Raccuglia D, McCurdy LY, Demir M, Gorur-Shandilya S, Kunst M, Emonet T, Nitabach MN. Presynaptic GABA Receptors Mediate Temporal Contrast Enhancement in Drosophila Olfactory Sensory Neurons and Modulate Odor-Driven Behavioral Kinetics. ENeuro 2016, 3: eneuro.0080-16.2016. PMID: 27588305, PMCID: PMC4994068, DOI: 10.1523/eneuro.0080-16.2016.Peer-Reviewed Original ResearchConceptsOlfactory sensory neuronsPeripheral responsesGABA receptorsSensory neuronsContrast enhancementOSN axon terminalsInhibitory GABA receptorsPresynaptic GABAAxon terminalsDrosophila olfactory sensory neuronsPresynaptic terminalsNervous systemAuditory stimuliTemporal edgeOlfactory systemTime courseNeuronsInnate behavioral responsesReceptorsOptical electrophysiologyTemporal contrast enhancementBehavioral responsesLateral inhibitionResponseGABA
2015
Exploring the Biology of G Protein–Coupled Receptors from In Vitro to In Vivo
Bohn LM, Lohse MJ, Nitabach MN, Taghert PH, Smit MJ. Exploring the Biology of G Protein–Coupled Receptors from In Vitro to In Vivo. Molecular Pharmacology 2015, 88: 534-535. PMID: 26162863, DOI: 10.1124/mol.115.100750.Peer-Reviewed Original Research
2014
Rhythmic control of activity and sleep by class B1 GPCRs
Kunst M, Tso MC, Ghosh DD, Herzog ED, Nitabach MN. Rhythmic control of activity and sleep by class B1 GPCRs. Critical Reviews In Biochemistry And Molecular Biology 2014, 50: 18-30. PMID: 25410535, PMCID: PMC4648372, DOI: 10.3109/10409238.2014.985815.Peer-Reviewed Original ResearchConceptsGenetic model organismClass B1 GPCRsModel organismsC. elegansMetazoan cladesMolecular roleCircadian timekeepingB1 familyMolecular mechanismsG proteinsRhythmic controlDaily rhythmsCircadian rhythmRemarkable parallelsMultiple cellsDrosophilaCladeElegansPDFRGPCRsIntercellularReceptorsOrganismsVPAC2 receptorsTimekeepingCalcitonin Gene-Related Peptide Neurons Mediate Sleep-Specific Circadian Output in Drosophila
Kunst M, Hughes ME, Raccuglia D, Felix M, Li M, Barnett G, Duah J, Nitabach MN. Calcitonin Gene-Related Peptide Neurons Mediate Sleep-Specific Circadian Output in Drosophila. Current Biology 2014, 24: 2652-2664. PMID: 25455031, PMCID: PMC4255360, DOI: 10.1016/j.cub.2014.09.077.Peer-Reviewed Original ResearchConceptsPigment-dispersing factorNeuropeptide calcitonin gene-related peptideCalcitonin gene-related peptideGene-related peptidePDF receptorClock neuronsCircadian clock neuronsDistinct neuronal pathwaysNeuropeptide pigment-dispersing factorDorsal clock neuronsAmount of sleepHomeostatic sleep driveNeurons actsCalcitonin geneNeuronal pathwaysTiming of sleepSleepMental healthSleep driveReceptorsNovel roleCircadian rhythmDH31NeuronsLocomotor rhythm
2013
Membrane-Tethered Ligands: Tools for Cell-Autonomous Pharmacological Manipulation of Biological Circuits
Choi C, Nitabach MN. Membrane-Tethered Ligands: Tools for Cell-Autonomous Pharmacological Manipulation of Biological Circuits. Physiology 2013, 28: 164-171. PMID: 23636262, PMCID: PMC4073904, DOI: 10.1152/physiol.00056.2012.Peer-Reviewed Original ResearchConceptsMembrane-tethered ligandsCellular circuitsCell surface receptorsCognate cell surface receptorsCell-autonomous mannerG protein-coupled receptorsCell-specific promoterIon channel subtypesIntercellular communication pathwaysRecombinant transgeneBiological processesStructural modulesBiological circuitsBiological significanceIon channelsSpecific phenotypesSurface receptorsCommunication pathwaysPhysiological circuitsSpecific manipulationChannel subtypesReceptorsSuch manipulationsPharmacological manipulationPromoter