2017
A Peptidergic Circuit Links the Circadian Clock to Locomotor Activity
King AN, Barber AF, Smith AE, Dreyer AP, Sitaraman D, Nitabach MN, Cavanaugh DJ, Sehgal A. A Peptidergic Circuit Links the Circadian Clock to Locomotor Activity. Current Biology 2017, 27: 1915-1927.e5. PMID: 28669757, PMCID: PMC5698909, DOI: 10.1016/j.cub.2017.05.089.Peer-Reviewed Original ResearchConceptsLocomotor activitySubesophageal zonePeptidergic circuitsPars intercerebralisCorticotropin-releasing factorVentral nerve cordSite of actionReceptor 1Motor outputCircadian locomotor activityNerve cordNeuronsRelevant receptorsDrosophila brainHr rhythmsCircadian driveRhythmFeeding rhythmDiuretic hormone 44Minimal effectActivity rhythmsBehavioral rhythmsCircadian locomotionCircadian controlCord
2012
Deep sequencing the circadian and diurnal transcriptome of Drosophila brain
Hughes ME, Grant GR, Paquin C, Qian J, Nitabach MN. Deep sequencing the circadian and diurnal transcriptome of Drosophila brain. Genome Research 2012, 22: 1266-1281. PMID: 22472103, PMCID: PMC3396368, DOI: 10.1101/gr.128876.111.Peer-Reviewed Original ResearchMeSH KeywordsAlternative SplicingAnimalsBase SequenceBrainCircadian ClocksCircadian RhythmDrosophila melanogasterExonsGene Expression ProfilingMolecular Sequence AnnotationPhotoperiodRNA EditingRNA IsoformsRNA Splice SitesRNA, UntranslatedSequence AlignmentSequence Analysis, RNATranscription, GeneticTranscriptomeConceptsKey circadian genesRNA editingNoncoding RNAsCircadian genesDrosophila brainGenome-wide mapsEukaryotic circadian clocksCircadian transcriptional rhythmsSnoRNA host genesTranslational feedback loopsSmall nucleolar RNAsNovel splicing eventsAlternative splice isoformsDark diurnal cyclesFrequency of RNAPrevious microarray studyDiurnal transcriptomeDrosophila melanogaster brainTranscriptional rhythmsCircadian transcriptomeNcRNA expressionRibosomal biogenesisModENCODE consortiumSplicing eventsAlternative splicing