The insulin receptor translocates to the nucleus to regulate cell proliferation in liver
Amaya MJ, Oliveira AG, Guimarães ES, Casteluber MC, Carvalho SM, Andrade LM, Pinto MC, Mennone A, Oliveira CA, Resende RR, Menezes GB, Nathanson MH, Leite MF. The insulin receptor translocates to the nucleus to regulate cell proliferation in liver. Hepatology 2013, 59: 274-283. PMID: 23839970, PMCID: PMC3823683, DOI: 10.1002/hep.26609.Peer-Reviewed Original ResearchConceptsInsulin's metabolic effectsInsulin's mitogenic effectsInsulin receptorCell proliferationMitogenic effectMetabolic effectsInsulin-induced increaseFormation of inositolHepatic glucose metabolismInsulin's abilityFormation of InsP3Potential targetPathwayTherapeutic modulationGlucose metabolismProliferationInsP3Partial hepatectomyHepatic mitogenLiver growthLiver regenerationNucleusClathrinReceptorsLiver