2003
Nuclear and cytosolic calcium are regulated independently
Leite MF, Thrower EC, Echevarria W, Koulen P, Hirata K, Bennett AM, Ehrlich BE, Nathanson MH. Nuclear and cytosolic calcium are regulated independently. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 2975-2980. PMID: 12606721, PMCID: PMC151451, DOI: 10.1073/pnas.0536590100.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateCalciumCalcium ChannelsCell LineCell MembraneCell NucleusCytosolDose-Response Relationship, DrugEndoplasmic ReticulumHumansImmunoblottingImmunohistochemistryInositol 1,4,5-Trisphosphate ReceptorsLipid BilayersMicroscopy, ConfocalProtein IsoformsReceptors, Cytoplasmic and NuclearSignal TransductionTime FactorsConceptsEndoplasmic reticulumImportant cellular processesType II isoformCellular processesCellular compartmentsGene transcriptionEnriched expressionNuclear calciumTrisphosphate receptorIndependent regulationCytosolLiver cell lineCell linesHepG2 liver cell lineSubcellular mechanismsReticulumNucleus resultsDependent processesCytosolic calciumNucleusTranscriptionType ISignalingIsoformsSimilar extent
2001
Bile duct epithelia regulate biliary bicarbonate excretion in normal rat liver
Hirata K, Nathanson M. Bile duct epithelia regulate biliary bicarbonate excretion in normal rat liver. Gastroenterology 2001, 121: 396-406. PMID: 11487549, DOI: 10.1053/gast.2001.26280.Peer-Reviewed Original ResearchMeSH Keywords4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAcetylcholineAngiogenesis InhibitorsAnimalsAnti-Inflammatory Agents, Non-SteroidalBicarbonatesBileBile DuctsBiological TransportCalciumCyclic AMPCyclosporineDose-Response Relationship, DrugEnzyme InhibitorsEpithelial CellsGlucagonHepatic ArteryHepatic VeinsIn Vitro TechniquesLiverMaleNitrobenzoatesOrtho-AminobenzoatesRatsRats, Sprague-DawleySecretinVasoconstrictor AgentsVasodilator AgentsVasopressinsConceptsBiliary bicarbonate excretionEffect of secretinBicarbonate excretionHepatic arteryBiliary bicarbonateNormal rat liverDiphenylamine-2-carboxylic acidBile ductPortal veinRat liverEffects of acetylcholineBile duct epitheliumDose-dependent fashionFormation of bileBile flowBlood supplyBicarbonate exchangeDuct epitheliumAcetylcholineArteryAbstractTextExcretionCyclosporin A.LiverCholangiocytes
1998
Telenzepine-sensitive muscarinic receptors on rat pancreatic acinar cells
Schmid S, Modlin I, Tang L, Stoch A, Rhee S, Nathanson M, Scheele G, Gorelick F. Telenzepine-sensitive muscarinic receptors on rat pancreatic acinar cells. American Journal Of Physiology 1998, 274: g734-g741. PMID: 9575856, DOI: 10.1152/ajpgi.1998.274.4.g734.Peer-Reviewed Original ResearchConceptsPancreatic acinar cellsAmylase secretionRat pancreatic acinar cellsMuscarinic receptorsAcinar cellsDifferent muscarinic receptor antagonistsM2 antagonist methoctramineMaximal amylase secretionMuscarinic receptor antagonistIsolated rat pancreatic aciniRat pancreatic aciniAntagonist methoctramineM3 subtypeM1 antagonistMuscarinic subtypesReceptor antagonistZymogen processingAntagonist sensitivityPancreatic aciniSecretionAntagonistSubtypesPotent inhibitorReceptorsDistinct patterns