2003
Regulation of calcium signals in the nucleus by a nucleoplasmic reticulum
Echevarría W, Leite MF, Guerra MT, Zipfel WR, Nathanson MH. Regulation of calcium signals in the nucleus by a nucleoplasmic reticulum. Nature Cell Biology 2003, 5: 440-446. PMID: 12717445, PMCID: PMC3572851, DOI: 10.1038/ncb980.Peer-Reviewed Original ResearchMeSH KeywordsActive Transport, Cell NucleusCalciumCalcium ChannelsCalcium SignalingCell MembraneCell Nucleus StructuresCytosolEndoplasmic ReticulumEukaryotic CellsHumansInositol 1,4,5-TrisphosphateInositol 1,4,5-Trisphosphate ReceptorsMicroscopy, ConfocalNuclear EnvelopePhotochemistryProtein Kinase CProtein TransportReceptors, Cytoplasmic and NuclearTumor Cells, CulturedConceptsProtein kinase CNucleoplasmic reticulumCalcium signalsNuclear envelopeNuclear protein kinase CNuclear calcium signalsCytosolic protein kinase CGene transcriptionInduces translocationNuclear calcium storesPlasma membraneCytosolic calcium signalsSubnuclear regionsEndoplasmic reticulumSecond messengerKinase CTrisphosphate receptorCell growthReticulumNuclear componentsReticular networkPotential mechanismsCalcium storesRelease of calciumNucleusNuclear and cytosolic calcium are regulated independently
Leite MF, Thrower EC, Echevarria W, Koulen P, Hirata K, Bennett AM, Ehrlich BE, Nathanson MH. Nuclear and cytosolic calcium are regulated independently. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 2975-2980. PMID: 12606721, PMCID: PMC151451, DOI: 10.1073/pnas.0536590100.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateCalciumCalcium ChannelsCell LineCell MembraneCell NucleusCytosolDose-Response Relationship, DrugEndoplasmic ReticulumHumansImmunoblottingImmunohistochemistryInositol 1,4,5-Trisphosphate ReceptorsLipid BilayersMicroscopy, ConfocalProtein IsoformsReceptors, Cytoplasmic and NuclearSignal TransductionTime FactorsConceptsEndoplasmic reticulumImportant cellular processesType II isoformCellular processesCellular compartmentsGene transcriptionEnriched expressionNuclear calciumTrisphosphate receptorIndependent regulationCytosolLiver cell lineCell linesHepG2 liver cell lineSubcellular mechanismsReticulumNucleus resultsDependent processesCytosolic calciumNucleusTranscriptionType ISignalingIsoformsSimilar extent
1998
Novel paracrine signaling mechanism in the ocular ciliary epithelium
Hirata K, Nathanson M, Sears M. Novel paracrine signaling mechanism in the ocular ciliary epithelium. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 8381-8386. PMID: 9653195, PMCID: PMC20984, DOI: 10.1073/pnas.95.14.8381.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalciumCiliary BodyEpithelial CellsMaleMicroscopy, ConfocalParacrine CommunicationRabbitsConceptsNonpigmented cell layerCiliary epithelial bilayerAlpha1-adrenergic antagonist prazosinBeta-adrenergic antagonist propranololPigmented cell layerGap junction blocker octanolBeta-adrenergic agonist isoproterenolCell layerEpithelial bilayerEndogenous adenylyl cyclaseGap junctionsCell spreadOcular ciliary epitheliumAntagonist prazosinAqueous humor secretionAntagonist propranololCiliary bodyAgonist isoproterenolParacrine pathwaysAdrenergic stimulationNovel paracrineCytosolic Ca2Lucifer YellowCiliary epitheliumAdenylyl cyclase
1995
Differences in laser-induced autofluorescence between adenomatous and hyperplastic polyps and normal colonic mucosa by confocal microscopy
Fiarman G, Nathanson M, Brian West A, Deckelbaum L, Kelly L, Kapadia C. Differences in laser-induced autofluorescence between adenomatous and hyperplastic polyps and normal colonic mucosa by confocal microscopy. Digestive Diseases And Sciences 1995, 40: 1261-1268. PMID: 7781444, DOI: 10.1007/bf02065535.Peer-Reviewed Original Research