Nuclear and cytosolic calcium are regulated independently
Leite MF, Thrower EC, Echevarria W, Koulen P, Hirata K, Bennett AM, Ehrlich BE, Nathanson MH. Nuclear and cytosolic calcium are regulated independently. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 2975-2980. PMID: 12606721, PMCID: PMC151451, DOI: 10.1073/pnas.0536590100.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateCalciumCalcium ChannelsCell LineCell MembraneCell NucleusCytosolDose-Response Relationship, DrugEndoplasmic ReticulumHumansImmunoblottingImmunohistochemistryInositol 1,4,5-Trisphosphate ReceptorsLipid BilayersMicroscopy, ConfocalProtein IsoformsReceptors, Cytoplasmic and NuclearSignal TransductionTime FactorsConceptsEndoplasmic reticulumImportant cellular processesType II isoformCellular processesCellular compartmentsGene transcriptionEnriched expressionNuclear calciumTrisphosphate receptorIndependent regulationCytosolLiver cell lineCell linesHepG2 liver cell lineSubcellular mechanismsReticulumNucleus resultsDependent processesCytosolic calciumNucleusTranscriptionType ISignalingIsoformsSimilar extent