2014
Post-translational Regulation of the Type III Inositol 1,4,5-Trisphosphate Receptor by miRNA-506*
Ananthanarayanan M, Banales JM, Guerra MT, Spirli C, Munoz-Garrido P, Mitchell-Richards K, Tafur D, Saez E, Nathanson MH. Post-translational Regulation of the Type III Inositol 1,4,5-Trisphosphate Receptor by miRNA-506*. Journal Of Biological Chemistry 2014, 290: 184-196. PMID: 25378392, PMCID: PMC4281721, DOI: 10.1074/jbc.m114.587030.Peer-Reviewed Original ResearchConceptsReporter activityMiR-506Trisphosphate receptorPost-translational regulationMiR-506 mimicsCell linesMiR-506 inhibitorEpigenetic regulationMiRNA regulationType III inositolFibrotic signatureMiR-506 expressionType III isoformCholangiocyte cell lineHEK293 cellsSitu hybridizationProtein levelsControl cellsInsP3R3H69 cellsRegulationSignalingExpressionCellsInositol
2007
c-Met Must Translocate to the Nucleus to Initiate Calcium Signals* ♦
Gomes DA, Rodrigues MA, Leite MF, Gomez MV, Varnai P, Balla T, Bennett AM, Nathanson MH. c-Met Must Translocate to the Nucleus to Initiate Calcium Signals* ♦. Journal Of Biological Chemistry 2007, 283: 4344-4351. PMID: 18073207, PMCID: PMC2825875, DOI: 10.1074/jbc.m706550200.Peer-Reviewed Original ResearchConceptsHepatocyte growth factorC-MetAdaptor protein Gab1Protein Gab1C-Met signalingImportin beta1Plasma membraneReceptor c-MetBisphosphate hydrolysisCell proliferationCalcium signalsPathwayTrisphosphate formationGrowth factorCytoplasmTranslocationNucleusGab1PhosphatidylinositolSignalingInositolDifferentiationProliferationMembraneBeta1