Metformin Prevents the Progression of Dysplastic Mucosa of the Head and Neck to Carcinoma in Nondiabetic Patients
Lerner MZ, Mor N, Paek H, Blitzer A, Strome M. Metformin Prevents the Progression of Dysplastic Mucosa of the Head and Neck to Carcinoma in Nondiabetic Patients. Annals Of Otology Rhinology & Laryngology 2017, 126: 340-343. PMID: 28103701, DOI: 10.1177/0003489416688478.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaAdjuvant metformin therapyHNC patientsMetformin therapyDiabetes mellitusOral cavity squamous cell carcinomaType 2 diabetes mellitusLaryngeal squamous cell carcinomaOral anti-hyperglycemic agentAbnormal glucose metabolismRisk of malignancyAnti-hyperglycemic agentsMultifocal dysplastic lesionsNondiabetic patientsAdjuvant therapyNondiabetic populationOverall survivalAdditional surgeryMucosal lesionsCase seriesOral lesionsCell carcinomaNeck cancerDysplastic lesionsDysplastic mucosa