1995
Functional expression and segmental localization of rat colonic K-adenosine triphosphatase.
Lee J, Rajendran V, Mann A, Kashgarian M, Binder H. Functional expression and segmental localization of rat colonic K-adenosine triphosphatase. Journal Of Clinical Investigation 1995, 96: 2002-2008. PMID: 7560093, PMCID: PMC185838, DOI: 10.1172/jci118247.Peer-Reviewed Original Research
1993
Transport defects of rabbit inner medullary collecting duct cells in obstructive nephropathy
Hwang S, Harris H, Otuechere G, Yalla S, Sullivan M, Kashgarian M, Benos D, Kleyman T, Zeidel M. Transport defects of rabbit inner medullary collecting duct cells in obstructive nephropathy. American Journal Of Physiology 1993, 264: f808-f815. PMID: 8388652, DOI: 10.1152/ajprenal.1993.264.5.f808.Peer-Reviewed Original ResearchConceptsObstructed kidneysIMCD cellsUntreated control kidneysOuabain-insensitive QO2Ouabain-sensitive QO2Urinary obstructionObstructive nephropathyControl kidneysControl animalsControl groupKidneyMonoclonal antibodiesMarked reductionDuct cellsAlpha 1Cellular mechanismsSignificant differencesChannel proteinsReabsorptionAntibodiesOxygen consumption studiesTransport defectRabbitsCellsImmunoblotTransport defects of rabbit medullary thick ascending limb cells in obstructive nephropathy.
Hwang S, Haas M, Harris H, Silva P, Yalla S, Sullivan M, Otuechere G, Kashgarian M, Zeidel M. Transport defects of rabbit medullary thick ascending limb cells in obstructive nephropathy. Journal Of Clinical Investigation 1993, 91: 21-28. PMID: 8380811, PMCID: PMC329990, DOI: 10.1172/jci116173.Peer-Reviewed Original ResearchConceptsMedullary thick ascending limbNa-K-ATPase activityNa-K-ATPaseBasolateral Na-K-ATPaseObstructed kidneysObstructive nephropathyUreteral obstructionLuminal NaRelease of obstructionThick ascending limbMajor sodium transportersUntreated kidneysTransport defectSpecific monoclonal antibodiesSodium transport defectsControl animalsAscending limbOuter medullaKidneyApical NaMarked reductionMonoclonal antibodiesMTAL cellsInhibitory effectObstruction
1988
Morphological heterogeneity of the rabbit collecting duct
Ridderstrale Y, Kashgarian M, Koeppen B, Giebisch G, Stetson D, Ardito T, Stanton B. Morphological heterogeneity of the rabbit collecting duct. Kidney International 1988, 34: 655-670. PMID: 2462075, DOI: 10.1038/ki.1988.230.Peer-Reviewed Original Research
1986
No aggravation of the course of experimental glomerulonephritis in spontaneously hypertensive rats.
Stein H, Sterzel R, Hunt J, Pabst R, Kashgarian M. No aggravation of the course of experimental glomerulonephritis in spontaneously hypertensive rats. American Journal Of Pathology 1986, 122: 520-30. PMID: 3513602, PMCID: PMC1888211.Peer-Reviewed Original ResearchMeSH KeywordsAlbuminuriaAnimalsAntibodies, Anti-IdiotypicAntibody FormationAutoradiographyBlood PressureFluorescent Antibody TechniqueGlomerulonephritisHistocytochemistryHypertensionImmune System DiseasesImmunoglobulin GKidneyMaleMicroscopy, ElectronRabbitsRatsRats, Inbred SHRRats, Inbred WKYThymidineConceptsWistar-Kyoto controlsBlood pressureGBM nephritisRenal injurySystemic hypertensionHypertensive ratsNormotensive Wistar-Kyoto (WKY) controlsAntiglomerular basement membrane nephritisUrinary albumin excretionSystolic blood pressureIgG antibody productionHumoral antibody responseNonspecific esteraseLight microscopyAlbumin excretionAutoregulatory capacityControl SHRMild hypertensionMorphologic injuryCreatinine clearanceGlomerular alterationsSerum creatinineNSE stainingHumoral responseAntibody responseProgressive Glomerular Sclerosis in Experimental Antiglomerular Basement Membrane Glomerulonephritis
Foellmer H, Sterzel R, Kashgarian M. Progressive Glomerular Sclerosis in Experimental Antiglomerular Basement Membrane Glomerulonephritis. American Journal Of Kidney Diseases 1986, 7: 5-11. PMID: 3510536, DOI: 10.1016/s0272-6386(86)80050-6.Peer-Reviewed Original ResearchConceptsGlomerular filtration rateAntiglomerular basement membrane glomerulonephritisProgressive glomerular sclerosisGlomerular sclerosisPara-aminohippuric acidGlomerular hypercellularityFiltration fractionWistar ratsInitial inflammatory changesNormal renal clearanceIntrinsic glomerular cellsChronic glomerulosclerosisRenal insufficiencyInflammatory changesAcute phaseChronic phaseSignificant proteinuriaFiltration rateLeukocytic infiltrationCrescent formationFunctional abnormalitiesSclerotic processRenal clearanceGlomerular cellsGlomerulonephritis
1975
Diffuse glomerulonephritis in rabbits with Streptococcus viridans endocarditis.
Arnold S, Valone J, Askenase P, Kashgarian M, Freedman L. Diffuse glomerulonephritis in rabbits with Streptococcus viridans endocarditis. Laboratory Investigation 1975, 32: 681-9. PMID: 125360.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, BacterialComplement C3Disease Models, AnimalEndocarditis, BacterialFluorescent Antibody TechniqueGlomerulonephritisHistological TechniquesImmune Complex DiseasesImmunizationImmunoglobulin GKidneyMaleMicroscopy, ElectronMicroscopy, FluorescenceRabbitsRheumatoid FactorSplenomegalyStreptococcal InfectionsConceptsInfective endocarditisDiffuse glomerulonephritisSubendothelial electron-dense depositsStreptococcus viridans endocarditisDeposition of IgGDiffuse proliferative glomerulonephritisSerum complement levelsAcute diffuse proliferative glomerulonephritisPositive blood culturesElectron microscopic findingsElectron-dense depositsComplement levelsGlomerular changesValvular vegetationsRheumatoid factorLeukocytic infiltrationMesangial proliferationProliferative glomerulonephritisBlood culturesImmune mechanismsCapillary occlusionMorphologic findingsIntravenous administrationMicroscopic findingsEndocarditis