The maximal cytoprotective function of the heat shock protein 27 is dependent on heat shock protein 70
Sreedharan R, Riordan M, Thullin G, Van Why S, Siegel NJ, Kashgarian M. The maximal cytoprotective function of the heat shock protein 27 is dependent on heat shock protein 70. Biochimica Et Biophysica Acta 2010, 1813: 129-135. PMID: 20934464, PMCID: PMC3014454, DOI: 10.1016/j.bbamcr.2010.08.012.Peer-Reviewed Original ResearchConceptsHeat shock protein 70Shock protein 70Cell injuryProtein 70Heat shock protein 27Renal cell injuryExpression of HSP27Maximal cytoprotective effectShock protein 27Endogenous hspNuclear binding sitesCytoprotective effectsInjuryRenal cellsLLC-PK1 cellsProtein 27Specific siRNAHSP-70HSP70 inductionRespective controlsHSP27Particular HSP70Cytoprotective functionEnergy depletionATP depletion