The mesangium and glomerulonephritis
Sterzel R, Lovett D, Stein H, Kashgarian M. The mesangium and glomerulonephritis. Journal Of Molecular Medicine 1982, 60: 1077-1094. PMID: 7144055, DOI: 10.1007/bf01715838.Peer-Reviewed Original ResearchConceptsGlomerular diseaseImmune competent cellsProgressive glomerular sclerosisExperimental glomerular diseaseMesangial cell proliferationMesangial spacePeripheral capillary wallsCertain glomerular diseasesLocal hemodynamic factorsIntrinsic mesangial cellsGlomerular basement membraneMesangial dysfunctionGlomerular sclerosisInflammatory cellsGlomerular hypertensionHistopathologic studyMarked proteinuriaGlomerular disordersSubendothelial depositsPericapillary tissueTherapeutic approachesImmune complexesFunctional damageMesangial abnormalitiesCapillary pericytesMesangial disposal of glomerular immune deposits in acute malarial glomerulonephritis of rats.
Sterzel R, Ehrich J, Lucia H, Thomson D, Kashgarian M. Mesangial disposal of glomerular immune deposits in acute malarial glomerulonephritis of rats. Laboratory Investigation 1982, 46: 209-14. PMID: 7038293.Peer-Reviewed Original ResearchConceptsGlomerular immune depositsImmune depositsElectron-dense depositsDay 10Day 20Young Sprague-Dawley ratsRenal functional damageUrinary protein excretionInfiltration of monocytesGlomerular cell countSprague-Dawley ratsEsterase-positive monocytesGlomerular basement membraneAcute malariaProtein excretionGlomerular injuryMesangial distributionSerum urea valuesDay 100Granular depositionImmune complexesFunctional damageNormal rangeMesangial matrixCell count