2009
W1646 DSS-Induced Colonic Inflammation Inhibits HCO3-Stimulated But Not Butyrate-Stimulated Na Absorption in Rat Distal Colon
Shanmugam N, Kashgarian M, Binder H, Rajendran V. W1646 DSS-Induced Colonic Inflammation Inhibits HCO3-Stimulated But Not Butyrate-Stimulated Na Absorption in Rat Distal Colon. Gastroenterology 2009, 136: a-709. DOI: 10.1016/s0016-5085(09)63270-4.Peer-Reviewed Original Research
1999
Colonic H-K-ATPase β-subunit: identification in apical membranes and regulation by dietary K depletion
Sangan P, Kolla S, Rajendran V, Kashgarian M, Binder H. Colonic H-K-ATPase β-subunit: identification in apical membranes and regulation by dietary K depletion. American Journal Of Physiology 1999, 276: c350-c360. PMID: 9950762, DOI: 10.1152/ajpcell.1999.276.2.c350.Peer-Reviewed Original ResearchDifferential regulation of NHE isoforms by sodium depletion in proximal and distal segments of rat colon
Ikuma M, Kashgarian M, Binder H, Rajendran V. Differential regulation of NHE isoforms by sodium depletion in proximal and distal segments of rat colon. American Journal Of Physiology 1999, 276: g539-g549. PMID: 9950829, DOI: 10.1152/ajpgi.1999.276.2.g539.Peer-Reviewed Original ResearchConceptsDietary sodium depletionSodium depletionDistal colonRat colonProtein expressionMRNA abundanceBlot analysisDose-dependent inhibitorApical membrane vesiclesElectroneutral NaCl absorptionWestern blot analysisDifferential regulationNormal ratsProximal colonHOE 694Multiple diverse effectsColonDistal segmentsNaCl absorptionNHE isoformsExchange activityExchanger isoformsNorthern blot analysisDifferential effectsPretranslational level
1997
Regulation of colonic H-K-ATPase in large intestine and kidney by dietary Na depletion and dietary K depletion
Sangan P, Rajendran V, Mann A, Kashgarian M, Binder H. Regulation of colonic H-K-ATPase in large intestine and kidney by dietary Na depletion and dietary K depletion. American Journal Of Physiology 1997, 272: c685-c696. PMID: 9124313, DOI: 10.1152/ajpcell.1997.272.2.c685.Peer-Reviewed Original ResearchConceptsDietary K depletionDistal colonNA depletionK-ATPase activityProximal colonLarge intestineRat distal colonActive K absorptionK-ATPaseRenal collecting ductsDietary NaK-ATPase expressionK-ATPase isoformsK depletionRat colonCollecting ductsOuter medullaColonProtein expressionProtein levelsKidneyPolyclonal antibodiesIntestineDuctMRNA
1989
Aldosterone induction of electrogenic sodium transport in the apical membrane vesicles of rat distal colon*
Rajendran V, Kashgarian M, Binder H. Aldosterone induction of electrogenic sodium transport in the apical membrane vesicles of rat distal colon*. Journal Of Biological Chemistry 1989, 264: 18638-18644. PMID: 2553716, DOI: 10.1016/s0021-9258(18)51514-3.Peer-Reviewed Original ResearchConceptsDistal colonRat distal colonNa-H exchangeElectrogenic sodium transportSodium transportExperimental ratsMicroM amilorideAmiloride-sensitive electrogenic sodium transportNormal rat distal colonEffects of aldosteroneElectroneutral sodium absorptionSodium concentrationApical membrane vesiclesAnalogues of amilorideVoltage-clamp conditionsDietary sodiumNormal ratsAldosterone inductionSodium absorptionColonComparable inhibitionRatsAmilorideAldosteronePotent inhibitor
1980
Chapter 10 Changes in Cell Membrane Surfaces Associated with Alterations of Transepithelial Ion Movement
Kashgarian M. Chapter 10 Changes in Cell Membrane Surfaces Associated with Alterations of Transepithelial Ion Movement. Current Topics In Membranes 1980, 13: 149-160. DOI: 10.1016/s0070-2161(08)60278-6.Peer-Reviewed Original ResearchDistal colonPotassium adaptationAcute potassium loadBiochemical changesGroups of animalsPotassium intakePotassium loadMineralocorticoid levelsChapter 10 ChangesProximal colonDistal tubulesSampling of cellsGreater passive permeabilityGlucocorticoid levelsMechanism of inductionEnhanced excretionMorphometric quantitationMembrane changesOrgan systemsColonDifferent physiologic statesUnadapted animalsBasolateral membrane surfaceEnhanced abilityPhysiologic state