1993
Transport defects of rabbit inner medullary collecting duct cells in obstructive nephropathy
Hwang S, Harris H, Otuechere G, Yalla S, Sullivan M, Kashgarian M, Benos D, Kleyman T, Zeidel M. Transport defects of rabbit inner medullary collecting duct cells in obstructive nephropathy. American Journal Of Physiology 1993, 264: f808-f815. PMID: 8388652, DOI: 10.1152/ajprenal.1993.264.5.f808.Peer-Reviewed Original ResearchConceptsObstructed kidneysIMCD cellsUntreated control kidneysOuabain-insensitive QO2Ouabain-sensitive QO2Urinary obstructionObstructive nephropathyControl kidneysControl animalsControl groupKidneyMonoclonal antibodiesMarked reductionDuct cellsAlpha 1Cellular mechanismsSignificant differencesChannel proteinsReabsorptionAntibodiesOxygen consumption studiesTransport defectRabbitsCellsImmunoblotTransport defects of rabbit medullary thick ascending limb cells in obstructive nephropathy.
Hwang S, Haas M, Harris H, Silva P, Yalla S, Sullivan M, Otuechere G, Kashgarian M, Zeidel M. Transport defects of rabbit medullary thick ascending limb cells in obstructive nephropathy. Journal Of Clinical Investigation 1993, 91: 21-28. PMID: 8380811, PMCID: PMC329990, DOI: 10.1172/jci116173.Peer-Reviewed Original ResearchConceptsMedullary thick ascending limbNa-K-ATPase activityNa-K-ATPaseBasolateral Na-K-ATPaseObstructed kidneysObstructive nephropathyUreteral obstructionLuminal NaRelease of obstructionThick ascending limbMajor sodium transportersUntreated kidneysTransport defectSpecific monoclonal antibodiesSodium transport defectsControl animalsAscending limbOuter medullaKidneyApical NaMarked reductionMonoclonal antibodiesMTAL cellsInhibitory effectObstruction
1991
Redistribution of cellular energy following renal ischemia
Gaudio K, Thulin G, Ardito T, Kashgarian M, Siegel N. Redistribution of cellular energy following renal ischemia. Pediatric Nephrology 1991, 5: 591-596. PMID: 1911145, DOI: 10.1007/bf00856647.Peer-Reviewed Original Research
1982
Accelerated recovery of single nephron function by the postischemic infusion of ATP-MgCl2
Gaudio K, Taylor M, Chaudry I, Kashgarian M, Siegel N. Accelerated recovery of single nephron function by the postischemic infusion of ATP-MgCl2. Kidney International 1982, 22: 13-20. PMID: 7120752, DOI: 10.1038/ki.1982.126.Peer-Reviewed Original ResearchConceptsClearance of inulinSingle nephron functionATP-MgCl2Proximal tubular pressureNephron functionTubular pressureBeneficial effectsRenal artery ischemiaSaline-treated animalsSaline-treated ratsCourse of recoveryGroups of animalsPostischemic administrationArtery ischemiaPattern of recoveryCIN 1Postischemic infusionInitial insultInulin clearanceInitial improvementControl animalsMost epithelial cellsEnhanced recoveryWhole kidneyTubular fluid
1980
Renal perfusion and intratubular pressure during ureteral occlusion in the rat
Gaudio K, Siegel N, Hayslett J, Kashgarian M. Renal perfusion and intratubular pressure during ureteral occlusion in the rat. American Journal Of Physiology 1980, 238: f205-f209. PMID: 7369362, DOI: 10.1152/ajprenal.1980.238.3.f205.Peer-Reviewed Original ResearchConceptsTotal renal blood flowBilateral ureteral occlusionBody wt-1Tubular hydrostatic pressureUreteral occlusionKidney 1WT-1Renal blood flowRenal hemodynamicsRenal perfusionIntratubular pressureBlood flowControl animalsSustained increasePeak riseOcclusionMmHgIndomethacinSubsequent time intervalsRatsPatterns of changeAlterationsAnimalsPrimary roleSubsequent time periods
1977
Renal function and cortical blood flow during the recovery phase of acute renal failure
Siegel N, Gunstream S, Handler R, Kashgarian M. Renal function and cortical blood flow during the recovery phase of acute renal failure. Kidney International 1977, 12: 199-204. PMID: 926611, DOI: 10.1038/ki.1977.101.Peer-Reviewed Original ResearchConceptsTotal renal blood flowGlomerular filtration rateAcute renal failureCortical blood flowRenal failureRenal functionBlood flowSham-injected control animalsOuter cortexOuter cortical perfusionRenal blood flowRecovery phaseCortical perfusionTubular functionSignificant diuresisFiltration rateInulin clearanceControl animalsDay 4Control valuesAbsolute perfusionProgressive improvementCortexEarly recovery phaseParallel increaseRENAL BLOOD FLOW AND GLOMERULAR PERFUSION DURING URETERAL OCCLUSION
Siegel N, Gunatream S, Kashgarian M. RENAL BLOOD FLOW AND GLOMERULAR PERFUSION DURING URETERAL OCCLUSION. Pediatric Research 1977, 11: 557-557. DOI: 10.1203/00006450-197704000-01125.Peer-Reviewed Original ResearchRenal blood flowGlomerular perfusionUreteral occlusionSuperficial cortexBlood flowObstructive nephropathyTotal renal blood flowBilateral ureteral occlusionRadioactive microsphere techniqueSham operated control animalsGlomerular hypoperfusionCortical ischemiaOperated control animalsCortical perfusionRenal injuryComplete ureteral occlusionMicrosphere techniqueSham operationControl animalsDeep cortexPerfusionControl valuesGlomerular countCortexOcclusion
1974
Compensatory adaptation of structure and function following progressive renal ablation
Kaufman J, DiMeola H, Siegel N, Lytton B, Kashgarian M, Hayslett J. Compensatory adaptation of structure and function following progressive renal ablation. Kidney International 1974, 6: 10-17. PMID: 4419711, DOI: 10.1038/ki.1974.72.Peer-Reviewed Original ResearchConceptsRenal ablationRenal tissueNephron glomerular filtration rateCompensatory adaptationGlomerular filtration rateClearance of inulinRenal insufficiencyUninephrectomized ratsFour-week intervalsFiltration rateRenal massesGroup BGroup AControl animalsGroup CLE ratsFunctional changesMass of tissueSegmental lossRatsSurgeryAdaptive changesAblationClearanceTissue
1973
The ultrastructure of the adrenal zona glomerulosa of rats on patassium-supplemented or sodium-depleted diets.
Domoto D, Boyd J, Mulrow P, Kashgarian M. The ultrastructure of the adrenal zona glomerulosa of rats on patassium-supplemented or sodium-depleted diets. American Journal Of Pathology 1973, 72: 433-46. PMID: 4728893, PMCID: PMC1904037.Peer-Reviewed Original ResearchConceptsSodium-deficient dietAldosterone productionPrincipal ultrastructural changesZona glomerulosa cellsAdrenal zona glomerulosaSodium-depleted animalsUltrastructural changesSodium-depleted dietGroups of animalsZona glomerulosaGlomerulosa cellsAdrenal cortexControl animalsMorphologic changesRatsSteroid synthesisMitochondrial changesDietAnimalsDaysInitial increaseGlomerulosaCortexCristae