2008
A Novel Form of Human Mendelian Hypertension Featuring Nonglucocorticoid-Remediable Aldosteronism
Geller DS, Zhang J, Wisgerhof MV, Shackleton C, Kashgarian M, Lifton RP. A Novel Form of Human Mendelian Hypertension Featuring Nonglucocorticoid-Remediable Aldosteronism. The Journal Of Clinical Endocrinology & Metabolism 2008, 93: 3117-3123. PMID: 18505761, PMCID: PMC2515083, DOI: 10.1210/jc.2008-0594.Peer-Reviewed Original ResearchConceptsGlucocorticoid-remediable aldosteronismAdrenal fasciculataAdministration of dexamethasoneAdrenal steroid productionAdrenal steroid biosynthesisNew familial formAge 7 yrSecondary hypertensionBilateral adrenalectomyMost patientsPrimary aldosteronismAdrenal weightClinical syndromeAdrenal glandCortisol secretionLeading causeAldosteronismHypertensionMedical treatmentAldosterone synthaseSteroid productionAutosomal dominant formCellular hypertrophyCortical compartmentFamilial forms
1984
Role of aldosterone in the mechanism of potassium adaptation in the initial collecting tubule
Hirsch D, Kashgarian M, Boulpaep E, Hayslett J. Role of aldosterone in the mechanism of potassium adaptation in the initial collecting tubule. Kidney International 1984, 26: 798-807. PMID: 6099857, DOI: 10.1038/ki.1984.221.Peer-Reviewed Original ResearchConceptsInitial collecting tubuleCollecting tubuleDistal convolutionAldosterone levelsPotassium adaptationChronic potassium loadingMineralocorticoid-sensitive tissuesRole of aldosteronePlasma aldosterone levelsAction of aldosteroneIntact adrenal glandsPotassium loadingPhysiological plasma levelsChronic hyperaldosteronismTransepithelial potential differenceChronic administrationEpithelial changesAdrenal glandPlasma levelsDietary potassium loadingBasal valuesAldosteroneTubule cellsNephron segmentsTarget tissues