2024
Extubation After Cardiac Surgery: It’s Better Early, If Often
Grant M. Extubation After Cardiac Surgery: It’s Better Early, If Often. The Annals Of Thoracic Surgery 2024, 118: 699-700. PMID: 39182952, DOI: 10.1016/j.athoracsur.2024.06.026.Peer-Reviewed Original ResearchTelehealth and Outcomes in Patients With Cancer
Grant M, Chiang A. Telehealth and Outcomes in Patients With Cancer. The Cancer Journal 2024, 30: 16-21. PMID: 38265921, DOI: 10.1097/ppo.0000000000000697.Peer-Reviewed Original ResearchConceptsCost-effective care deliveryDelivery of oncology careCare delivery mechanismsIn-person careEffectiveness of telehealthPatient-centered outcomesQuality of lifeCare deliveryCancer abstractsCancer careOncology careReduce disparitiesFinancial toxicityIn-personTelehealthPatient satisfactionCareCOVID-19 pandemicOutcomesCancerEfficacy endpointPatientsDeliveryCOVID-19Disparities
2023
Perioperative hemodynamic monitoring in cardiac surgery
Grant M, Salenger R, Lobdell K. Perioperative hemodynamic monitoring in cardiac surgery. Current Opinion In Anaesthesiology 2023, 37: 1-9. PMID: 38085877, DOI: 10.1097/aco.0000000000001327.Peer-Reviewed Original ResearchConceptsPulmonary artery catheterCardiac surgeryArtery catheterHemodynamic monitoringInvasive alternativeLow-risk cardiac surgeryInvasive hemodynamic monitoringLow-risk patientsPerioperative hemodynamic monitoringPulse contour analysisPatient's hemodynamicsResuscitation therapyBedside cliniciansInvasive approachInvasive monitoringRecent studiesSurgeryMonitoring modalitiesQuestionable benefitCatheterRegular useBroader indicationsPatientsSelective useUseful alternativeExtubation After Cardiac Surgery: It’s Not the Destination, It’s the Journey
Grant M. Extubation After Cardiac Surgery: It’s Not the Destination, It’s the Journey. The Annals Of Thoracic Surgery 2023, 117: 94-95. PMID: 37839538, DOI: 10.1016/j.athoracsur.2023.09.047.Peer-Reviewed Original ResearchPrecise, pragmatic and inclusive: the modern era of oncology clinical trials
Grant M, Goldberg S. Precise, pragmatic and inclusive: the modern era of oncology clinical trials. Nature Medicine 2023, 29: 1908-1909. PMID: 37524954, DOI: 10.1038/s41591-023-02466-6.Peer-Reviewed Original ResearchPractice Advisory for Preoperative and Intraoperative Pain Management of Cardiac Surgical Patients: Part 2
Makkad B, Heinke T, Sheriffdeen R, Khatib D, Brodt J, Meng M, Grant M, Kachulis B, Popescu W, Wu C, Bollen B. Practice Advisory for Preoperative and Intraoperative Pain Management of Cardiac Surgical Patients: Part 2. Anesthesia & Analgesia 2023, 137: 26-47. PMID: 37326862, DOI: 10.1213/ane.0000000000006506.Peer-Reviewed Original ResearchConceptsIntraoperative pain managementCardiac surgical patientsCardiac surgeryPain managementPractice advisorySurgical patientsEffective postoperative pain controlMultimodal analgesic strategyPostoperative pain controlPain management strategiesCardiac surgical proceduresPreoperative patient evaluationMeaningful patient outcomesHealth care costsAnalgesic strategiesMultimodal analgesicsOpioid exposurePain controlPerioperative usePostoperative distressFunctional recoveryPatient evaluationPatient outcomesRegional techniquesSurgical proceduresEnhanced Recovery After Surgery (ERAS®) Society Consensus Guidelines for Emergency Laparotomy Part 3: Organizational Aspects and General Considerations for Management of the Emergency Laparotomy Patient
Peden C, Aggarwal G, Aitken R, Anderson I, Balfour A, Foss N, Cooper Z, Dhesi J, French W, Grant M, Hammarqvist F, Hare S, Havens J, Holena D, Hübner M, Johnston C, Kim J, Lees N, Ljungqvist O, Lobo D, Mohseni S, Ordoñez C, Quiney N, Sharoky C, Urman R, Wick E, Wu C, Young-Fadok T, Scott M. Enhanced Recovery After Surgery (ERAS®) Society Consensus Guidelines for Emergency Laparotomy Part 3: Organizational Aspects and General Considerations for Management of the Emergency Laparotomy Patient. World Journal Of Surgery 2023, 47: 1881-1898. PMID: 37277506, PMCID: PMC10241556, DOI: 10.1007/s00268-023-07039-9.Peer-Reviewed Original ResearchConceptsOrganizational aspects of careAspects of careEnd-of-life issuesEmergency general surgical patientsComponents of careEnd-of-lifeModified Delphi processGrading of RecommendationsCare of patientsEnhanced recoveryOptimal care of patientsModified Delphi methodEmergency general surgeryEmergency laparotomy patientsLevel of evidenceEmergency laparotomyOrganizational aspectsSurgical patientsDelphi processOptimal careERAS elementsCohort studyHigh-risk patient populationSystematic reviewCareConsensus Guidelines for Perioperative Care for Emergency Laparotomy Enhanced Recovery After Surgery (ERAS®) Society Recommendations Part 2—Emergency Laparotomy: Intra‐ and Postoperative Care
Scott M, Aggarwal G, Aitken R, Anderson I, Balfour A, Foss N, Cooper Z, Dhesi J, French W, Grant M, Hammarqvist F, Hare S, Havens J, Holena D, Hübner M, Johnston C, Kim J, Lees N, Ljungqvist O, Lobo D, Mohseni S, Ordoñez C, Quiney N, Sharoky C, Urman R, Wick E, Wu C, Young-Fadok T, Peden C. Consensus Guidelines for Perioperative Care for Emergency Laparotomy Enhanced Recovery After Surgery (ERAS®) Society Recommendations Part 2—Emergency Laparotomy: Intra‐ and Postoperative Care. World Journal Of Surgery 2023, 47: 1850-1880. PMID: 37277507, PMCID: PMC10241558, DOI: 10.1007/s00268-023-07020-6.Peer-Reviewed Original ResearchConceptsEmergency laparotomyEmergency general surgical patientsComponents of careModified Delphi processGrading of RecommendationsCare of patientsOptimal care of patientsModified Delphi methodEmergency general surgeryConsensus guidelinesLevel of evidencePostoperative careHigh-risk patient populationDelphi processOptimal careERAS elementsManagement of high-riskCareCohort studyApproach to patientsGeneral surgical patientsSystematic reviewMEDLINE database searchMeta-analysesRandomized clinical trialsPerformance Comparison of Pulmonary Risk Scoring Systems in Lung Resection
Zorrilla-Vaca A, Grant M, Rehman M, Sarin P, Mendez-Pino L, Urman R, Varelmann D. Performance Comparison of Pulmonary Risk Scoring Systems in Lung Resection. Journal Of Cardiothoracic And Vascular Anesthesia 2023, 37: 1734-1743. PMID: 37330329, DOI: 10.1053/j.jvca.2023.05.035.Peer-Reviewed Original ResearchConceptsPostoperative pulmonary complicationsLung resection surgeryRisk-scoring systemPulmonary complicationsResection surgeryScoring systemLung resectionRisk scoreRisk of PPCsRetrospective cohort study SETTINGLAS VEGASAlternative risk scoresSingle-center cohortCohort study SETTINGAdult patientsExpiratory volumeLung surgeryThoracic surgeryPulmonary riskConcordance indexSurgeryPatientsDiscriminatory powerStudy settingComplicationsPractice Advisory for Preoperative and Intraoperative Pain Management of Thoracic Surgical Patients: Part 1
Makkad B, Heinke T, Sheriffdeen R, Khatib D, Brodt J, Meng M, Grant M, Kachulis B, Popescu W, Wu C, Bollen B. Practice Advisory for Preoperative and Intraoperative Pain Management of Thoracic Surgical Patients: Part 1. Anesthesia & Analgesia 2023, 137: 2-25. PMID: 37079466, DOI: 10.1213/ane.0000000000006441.Peer-Reviewed Original ResearchConceptsIntraoperative pain managementThoracic surgical patientsPain managementThoracic surgerySurgical patientsPractice advisoryEffective postoperative pain controlMultimodal analgesic strategyPostoperative pain controlPersistent postoperative painPain management strategiesPreoperative patient evaluationRelevant patient outcomesThoracic surgical proceduresAnalgesic strategiesMultimodal analgesicsOpioid exposurePain controlPostoperative painPerioperative usePostoperative distressFunctional recoveryPatient evaluationPatient outcomesRegional techniquesThe Evolving Role for Systemic Therapy in Resectable Non-small Cell Lung Cancer
Grant M, Woodard G, Goldberg S. The Evolving Role for Systemic Therapy in Resectable Non-small Cell Lung Cancer. Hematology/Oncology Clinics Of North America 2023, 37: 513-531. PMID: 37024389, DOI: 10.1016/j.hoc.2023.02.003.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerCell lung cancerLung cancerMetastatic non-small cell lung cancerResectable non-small cell lung cancerImmuno-oncology agentsHistologic classification systemUnited States FoodResectable tumorsSystemic therapyDriver alterationsDrug AdministrationStates FoodSystemic managementPatientsTherapyCancerEvolving roleClassification systemNTRKHER2TumorsKRASEGFRBRAFEfficacy of Osimertinib in Patients with Lung Cancer Positive for Uncommon EGFR Exon 19 Deletion Mutations
Grant M, Aredo J, Starrett J, Stockhammer P, van Rosenburgh I, Wurtz A, Piper-Valillo A, Piotrowska Z, Falcon C, Yu H, Aggarwal C, Scholes D, Patil T, Nguyen C, Phadke M, Li F, Neal J, Lemmon M, Walther Z, Politi K, Goldberg S. Efficacy of Osimertinib in Patients with Lung Cancer Positive for Uncommon EGFR Exon 19 Deletion Mutations. Clinical Cancer Research 2023, 29: of1-of8. PMID: 36913537, PMCID: PMC10493186, DOI: 10.1158/1078-0432.ccr-22-3497.Peer-Reviewed Original ResearchConceptsProgression-free survivalNon-small cell lung cancerInferior progression-free survivalMulticenter retrospective cohortEfficacy of osimertinibMulti-institutional cohortCell lung cancerExon 19 deletion mutationUncommon EGFRRetrospective cohortClinical outcomesClinical efficacyLung cancerOsimertinib efficacyEGFR mutationsPreclinical modelsEx19delPatientsAACR Genie databaseLater linesOsimertinibMutant cohortFirst lineCohortEfficacyPain management and opioid stewardship in adult cardiac surgery: Joint consensus report of the PeriOperative Quality Initiative and the Enhanced Recovery After Surgery Cardiac Society
Grant M, Chappell D, Gan T, Manning M, Miller T, Brodt J, Workgroup P, Shaw A, Engelman D, Mythen M, Guinn N, Aronson S, Schwartz J, Arora R, Morton-Bailey V, Brudney C, Bennett-Guerrero E, Reddy V, Guzzi L, Brown J, Crisafi C. Pain management and opioid stewardship in adult cardiac surgery: Joint consensus report of the PeriOperative Quality Initiative and the Enhanced Recovery After Surgery Cardiac Society. Journal Of Thoracic And Cardiovascular Surgery 2023, 166: 1695-1706.e2. PMID: 36868931, DOI: 10.1016/j.jtcvs.2023.01.020.Peer-Reviewed Original ResearchConceptsCardiac surgery patientsEnhanced recovery programmeHigh-dose opioidsOpioid stewardshipSurgery patientsPain managementCardiac surgeryNonopioid medicationsProvider educationOpioid prescription practicesCardiac surgery populationOptimal pain managementRole of opioidsAdult cardiac surgeryRegional anesthesia techniquesLevel of evidencePotential side effectsOptimal analgesiaOpioid administrationSurgery populationOpioid usePerioperative carePrescription practicesAnesthesia techniquesConsensus recommendationsPostoperative Hypoxemia After Dual-Controlled vs Volume-Controlled Ventilation in Lung Surgery
Zorrilla-Vaca A, Grant M, Rehman M, Sarin P, Varelmann D, Urman R. Postoperative Hypoxemia After Dual-Controlled vs Volume-Controlled Ventilation in Lung Surgery. The Annals Of Thoracic Surgery 2023, 116: 173-179. PMID: 36608756, DOI: 10.1016/j.athoracsur.2022.12.029.Peer-Reviewed Original ResearchConceptsLung resection surgeryPostoperative hypoxemiaResection surgeryPulmonary outcomesConventional ventilationAcute respiratory distress syndromeChronic obstructive pulmonary diseaseImproved pulmonary outcomesIntraoperative ventilator settingsPreoperative oxygen saturationSecondary pulmonary complicationsOne-lung ventilationObstructive pulmonary diseaseRespiratory distress syndromeLow tidal volumeVolume-controlled ventilationEligible patientsPRVC ventilationPulmonary complicationsRespiratory failureSecondary outcomesDistress syndromeLung surgeryPrimary outcomePulmonary disease
2022
Biochemical and structural basis for differential inhibitor sensitivity of EGFR with distinct exon 19 mutations
van Alderwerelt van Rosenburgh I, Lu D, Grant M, Stayrook S, Phadke M, Walther Z, Goldberg S, Politi K, Lemmon M, Ashtekar K, Tsutsui Y. Biochemical and structural basis for differential inhibitor sensitivity of EGFR with distinct exon 19 mutations. Nature Communications 2022, 13: 6791. PMID: 36357385, PMCID: PMC9649653, DOI: 10.1038/s41467-022-34398-z.Peer-Reviewed Original ResearchAn Expert Review of Chest Wall Fascial Plane Blocks for Cardiac Surgery
Hargrave J, Grant M, Kolarczyk L, Kelava M, Williams T, Brodt J, Neelankavil J. An Expert Review of Chest Wall Fascial Plane Blocks for Cardiac Surgery. Journal Of Cardiothoracic And Vascular Anesthesia 2022, 37: 279-290. PMID: 36414532, DOI: 10.1053/j.jvca.2022.10.026.Peer-Reviewed Original ResearchConceptsChest wall blocksPlane blockCardiac surgeryChest wallDeep serratus anterior plane blockCardiac surgical patient populationSerratus anterior plane blockErector spinae plane blockCardiac surgical populationChest wall analgesiaSurgical patient populationFascial plane blocksRegional anesthesia techniquesIpsilateral chest wallChest wall coverageSurgical populationEvidence-based implementationMedian sternotomySurgery pathwayPatient populationSurgical approachAnesthesia techniquesAnterior chestFascial planesInvasive techniquesIndividualised positive end-expiratory pressure in abdominal surgery: a systematic review and meta-analysis
Zorrilla-Vaca A, Grant M, Urman R, Frendl G. Individualised positive end-expiratory pressure in abdominal surgery: a systematic review and meta-analysis. British Journal Of Anaesthesia 2022, 129: 815-825. PMID: 36031417, DOI: 10.1016/j.bja.2022.07.009.Peer-Reviewed Original ResearchConceptsPositive end-expiratory pressureEnd-expiratory pressurePulmonary complicationsAbdominal surgerySystemic inflammationRisk ratioAcute respiratory distress syndromeLaird random-effects modelOverall pulmonary complicationsPostoperative pulmonary outcomesComposite primary outcomeEnd of surgerySystemic inflammatory markersRespiratory distress syndromeConfidence intervalsRandom-effects modelPostoperative atelectasisPrimary endpointPulmonary outcomesCochrane riskInflammatory markersLung injuryPostoperative hypoxaemiaSecondary outcomesBias toolRegional analgesia for cardiac surgery
Grant M, Gregory A, Ouanes J. Regional analgesia for cardiac surgery. Current Opinion In Anaesthesiology 2022, 35: 605-612. PMID: 35900740, DOI: 10.1097/aco.0000000000001169.Peer-Reviewed Original ResearchConceptsCardiac surgeryRegional analgesiaRegional techniquesCardiac surgical settingChest wall blocksOpioid-sparing analgesiaOpioid-sparing approachPain management expertsPerioperative patient careOpioid requirementsOpioid administrationPain controlPain managementPerioperative carePatients' qualityRegional anesthesiaAnalgesiaSurgical settingSurgeryPatient careCareAnesthesiaAdministrationInvestigating Opioid-Free Analgesia—Practice Makes Perfect
Grant M. Investigating Opioid-Free Analgesia—Practice Makes Perfect. JAMA Network Open 2022, 5: e2221441. PMID: 35849402, DOI: 10.1001/jamanetworkopen.2022.21441.Peer-Reviewed Original ResearchThe journey to standardizing cardiac perioperative care
Grant M, Engelman D. The journey to standardizing cardiac perioperative care. Anaesthesia Critical Care & Pain Medicine 2022, 41: 101099. PMID: 35715023, DOI: 10.1016/j.accpm.2022.101099.Peer-Reviewed Original Research