2017
Postoperative Multimodal Analgesia Pain Management With Nonopioid Analgesics and Techniques: A Review
Wick E, Grant M, Wu C. Postoperative Multimodal Analgesia Pain Management With Nonopioid Analgesics and Techniques: A Review. JAMA Surgery 2017, 152: 691-697. PMID: 28564673, DOI: 10.1001/jamasurg.2017.0898.Peer-Reviewed Original ResearchConceptsNonsteroidal anti-inflammatory agentsAnti-inflammatory agentsERAS pathwayPostoperative bleedingN-methyl-D-aspartate (NMDA) classMultimodal analgesia approachGlutamate receptor antagonistsCurrent opioid epidemicComplex surgical proceduresAnalgesic regimensOpioid consumptionLess opioidsMultimodal analgesiaNarcotic analgesiaNonopioid analgesicsHospital dischargeMost patientsPain managementRegional analgesiaSurgery pathwayReceptor antagonistClinical trialsOpioid epidemicEffective adjunctSurgical care
2016
The Effect of Preoperative Pregabalin on Postoperative Nausea and Vomiting
Grant M, Betz M, Hulse M, Zorrilla-Vaca A, Hobson D, Wick E, Wu C. The Effect of Preoperative Pregabalin on Postoperative Nausea and Vomiting. Anesthesia & Analgesia 2016, 123: 1100-1107. PMID: 27464972, DOI: 10.1213/ane.0000000000001404.Peer-Reviewed Original ResearchConceptsPreoperative pregabalinPostoperative nauseaPostoperative visual disturbancesPrevention of PONVSimilar antiemetic efficacyHigh-risk surgerySignificant reductionAdjuvant medicationsAntiemetic efficacyProphylactic antiemeticsThiopental inductionOpioid analgesiaPostoperative painSurgery protocolVisual disturbancesRandomized trialsRepeat dosingGeneral anesthesiaSubgroup analysisPregabalinEnhanced recoveryPONVNauseaVomitingTrials