2009
A Randomized Clinical Trial Investigating the Relationship Between Aprotinin and Hypercoagulabilityin Off-Pump Coronary Surgery
Desai P, Kurian D, Thirumavalavan N, Desai S, Ziu P, Grant M, White C, Landis R, Poston R. A Randomized Clinical Trial Investigating the Relationship Between Aprotinin and Hypercoagulabilityin Off-Pump Coronary Surgery. Anesthesia & Analgesia 2009, 109: 1387-1394. PMID: 19843776, PMCID: PMC2789288, DOI: 10.1213/ane.0b013e3181b81068.Peer-Reviewed Original ResearchMeSH KeywordsAprotininBlood CoagulationBlood Coagulation TestsBlood PlateletsCoronary Artery Bypass, Off-PumpDouble-Blind MethodErythrocyte TransfusionFibrinolytic AgentsGraft Occlusion, VascularHumansPeptide FragmentsPlatelet AdhesivenessPlatelet AggregationPlatelet Function TestsPostoperative HemorrhageProspective StudiesProthrombinReceptor, PAR-1ThrombinThrombosisTreatment OutcomeWound HealingConceptsMajor adverse cardiovascular eventsProtease-activated receptor 1Adverse cardiovascular eventsSaphenous vein graftsCardiovascular eventsOPCAB surgeryAprotinin groupCoronary sinusHypercoagulable stateVein graftsThrombin generationAntifibrinolytic propertiesPump coronary artery bypass surgeryOff-pump coronary surgeryCoronary artery bypass surgeryRed blood cell transfusionAprotinin-treated patientsFull-dose regimenArtery bypass surgeryBlood cell transfusionCoronary sinus bloodPAR-1 antagonistsPlatelet-leukocyte conjugatesPAR-1 activationPlatelet-derived microparticles
2008
Is Aprotinin Safe to Use in a Cohort at Increased Risk for Thrombotic Events: Results From a Randomized, Prospective Trial in Off-Pump Coronary Artery Bypass
Grant M, Kon Z, Joshi A, Christenson E, Kallam S, Burris N, Gu J, Poston R. Is Aprotinin Safe to Use in a Cohort at Increased Risk for Thrombotic Events: Results From a Randomized, Prospective Trial in Off-Pump Coronary Artery Bypass. The Annals Of Thoracic Surgery 2008, 86: 815-822. PMID: 18721566, PMCID: PMC2649734, DOI: 10.1016/j.athoracsur.2008.04.047.Peer-Reviewed Original ResearchMeSH KeywordsAprotininBlood Coagulation TestsCoronary Artery Bypass, Off-PumpFollow-Up StudiesGlomerular Filtration RateHemostaticsHumansPlatelet Function TestsPostoperative ComplicationsProspective StudiesThrombosisConceptsAcute kidney injuryCoronary artery bypassThrombotic eventsAprotinin levelsAprotinin useArtery bypassDay 3Off-pump coronary artery bypassMore acute kidney injuryPostoperative acute kidney injurySubsequent acute kidney injuryPump coronary artery bypassAcute graft failureAdverse thrombotic eventsWeight-based protocolPercentage of patientsGlomerular filtration rateFavorable safety profileMultiple randomized trialsPostoperative hypercoagulable stateEGFR declineCerebrovascular eventsKidney injuryLower eGFRPlacebo groupWarm ischemia provokes inflammation and regional hypercoagulability within the heart during off-pump coronary artery bypass: a possible target for serine protease inhibition
Kon Z, Brown E, Grant M, Ozeki T, Burris N, Collins M, Kwon M, Poston R. Warm ischemia provokes inflammation and regional hypercoagulability within the heart during off-pump coronary artery bypass: a possible target for serine protease inhibition. European Journal Of Cardio-Thoracic Surgery 2008, 33: 215-221. PMID: 18068996, PMCID: PMC2605708, DOI: 10.1016/j.ejcts.2007.11.008.Peer-Reviewed Original ResearchConceptsPump coronary artery bypassCoronary artery bypassTranscardiac gradientCoronary occlusionArtery bypassMyocardial ischemiaTNF-alphaCoronary sinus bloodEarly graft failureRegional myocardial ischemiaProthrombotic stateGraft failureProtamine administrationSinus bloodConsecutive patientsIschemic injuryMyocardial injuryIL-8Warm ischemiaPathophysiologic consequencesSeries of biomarkersCoagulation systemOPCABIschemiaInflammation
2007
Simultaneous hybrid coronary revascularization reduces postoperative morbidity compared with results from conventional off-pump coronary artery bypass
Kon Z, Brown E, Tran R, Joshi A, Reicher B, Grant M, Kallam S, Burris N, Connerney I, Zimrin D, Poston R. Simultaneous hybrid coronary revascularization reduces postoperative morbidity compared with results from conventional off-pump coronary artery bypass. Journal Of Thoracic And Cardiovascular Surgery 2007, 135: 367-375. PMID: 18242270, PMCID: PMC2962576, DOI: 10.1016/j.jtcvs.2007.09.025.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnalysis of VarianceCase-Control StudiesCohort StudiesCoronary AngiographyCoronary Artery Bypass, Off-PumpCoronary StenosisFemaleFollow-Up StudiesHumansInternal Mammary-Coronary Artery AnastomosisLength of StayLogistic ModelsMaleMiddle AgedPain, PostoperativePilot ProjectsPostoperative ComplicationsProbabilityRisk AssessmentSensitivity and SpecificitySeverity of Illness IndexTime FactorsTomography, X-Ray ComputedTreatment OutcomeVascular PatencyConceptsPump coronary artery bypassCoronary artery bypassTarget vessel patencyActivation of coagulationArtery bypassMyocardial injuryHybrid procedureOff-pump coronary artery bypassMultivessel coronary artery diseaseSimultaneous hybrid coronary revascularizationLeft internal thoracic arteryHybrid coronary revascularizationInternal thoracic arteryCoronary artery diseaseIntensive care unitBetter perioperative outcomesEnzyme-linked immunosorbentPromising preliminary findingsOverall total costTranscardiac gradientCoronary revascularizationPerioperative morbidityPerioperative outcomesPostoperative morbidityArtery disease