2022
Patient Characteristics Influencing Adherence to Enhanced Recovery Protocols for Colorectal Surgery: a Multicentric Prospective Study
Galarza-Prado A, Zorrilla-Vaca A, Healy R, Ripollés J, Abad-Motos A, Nozal-Mateo B, Del Rio S, Caballero-Lozada A, Stone A, Mena G, Grant M. Patient Characteristics Influencing Adherence to Enhanced Recovery Protocols for Colorectal Surgery: a Multicentric Prospective Study. Journal Of Gastrointestinal Surgery 2022, 26: 911-916. PMID: 35059982, DOI: 10.1007/s11605-021-05234-4.Peer-Reviewed Original ResearchMeSH KeywordsColorectal SurgeryCoronary Artery DiseaseGuideline AdherenceHumansHypoalbuminemiaLength of StayPostoperative ComplicationsProspective StudiesConceptsCoronary artery diseaseColorectal surgeryPreoperative hypoalbuminemiaPreoperative transfusionPatient characteristicsArtery diseaseHigh adherenceRecovery protocolMultivariable logistic regression analysisEnhanced recovery protocolMulticentric prospective studyLow complication rateLogistic regression analysisClinical characteristicsComplication rateMetastatic diseaseSurgical characteristicsCancer resectionSurgery guidelinesProspective studyAdequate adherenceUnivariate analysisLow adherenceMultivariable modelPatients
2020
Goal-Directed Fluid Therapy and Postoperative Outcomes in an Enhanced Recovery Program for Colorectal Surgery: A Propensity Score-Matched Multicenter Study
Zorrilla-Vaca A, Mena G, Ripolles-Melchor J, Abad-Motos A, Aldecoa C, Lorente J, Ramirez-Rodriguez J, Grant M. Goal-Directed Fluid Therapy and Postoperative Outcomes in an Enhanced Recovery Program for Colorectal Surgery: A Propensity Score-Matched Multicenter Study. The American Surgeon 2020, 87: 1189-1195. PMID: 33342254, DOI: 10.1177/0003134820973365.Peer-Reviewed Original ResearchConceptsGoal-directed fluid therapyEnhanced recovery programmeAcute kidney injurySurgical site infectionColorectal surgeryPostoperative outcomesFluid therapyPostoperative acute kidney injuryPropensity score-matched analysisComparable baseline demographicsMajor postoperative outcomesAdequate tissue perfusionRates of morbidityHospital stayKidney injuryBaseline demographicsCohort studyConventional careERAS programAnastomotic dehiscenceMajor surgerySite infectionPulmonary edemaMulticenter studyTherapy patientsRisk factors for acute kidney injury in an enhanced recovery pathway for colorectal surgery
Zorrilla-Vaca A, Mena G, Ripolles-Melchor J, Lorente J, Ramirez-Rodriguez J, Grant M. Risk factors for acute kidney injury in an enhanced recovery pathway for colorectal surgery. Surgery Today 2020, 51: 537-544. PMID: 32785846, DOI: 10.1007/s00595-020-02107-2.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAge FactorsAgedAged, 80 and overColonCreatinineDigestive System Surgical ProceduresEnhanced Recovery After SurgeryFemaleHumansMaleMalnutritionMiddle AgedMulticenter Studies as TopicNutritional StatusPostoperative ComplicationsProspective StudiesRectumRisk FactorsROC CurveSerum AlbuminConceptsPostoperative acute kidney injuryAcute kidney injuryColorectal surgeryRisk factorsKidney injuryLow preoperative albumin levelRecovery pathwaysPerioperative patient outcomesPreoperative albumin levelEnhanced recovery pathwayIndependent risk factorProspective cohort studyPoor clinical outcomeDirect healthcare costsOpen surgical approachMalnourished patientsCohort studyAlbumin levelsASA IIILarge multicenterPreoperative interventionClinical outcomesMultivariable analysisOverall incidenceModifiable factors
2017
Preserved Analgesia With Reduction in Opioids Through the Use of an Acute Pain Protocol in Enhanced Recovery After Surgery for Open Hepatectomy
Grant M, Sommer P, He C, Li S, Page A, Stone A, Hobson D, Wick E, Wu C. Preserved Analgesia With Reduction in Opioids Through the Use of an Acute Pain Protocol in Enhanced Recovery After Surgery for Open Hepatectomy. Regional Anesthesia & Pain Medicine 2017, 42: 451-457. PMID: 28525409, DOI: 10.1097/aap.0000000000000615.Peer-Reviewed Original ResearchConceptsOpen hepatectomyPain scoresERAS pathwayERAS protocolEnd pointPain controlSelf-reported pain scoresAcute pain protocolsAverage pain scoreLess morphine equivalentsMorphine equivalent requirementsOpioid-based medicationsProvision of fluidsLiver resection surgeryOptimal pain controlUse of epiduralsLength of stayHigh-risk procedurePostoperative end pointsERAS settingMorphine equivalentsNonepidural groupOpioid requirementsPerioperative opioidsEpidural analgesia
2016
Patient outcomes and provider perceptions following implementation of a standardized perioperative care pathway for open liver resection
Page A, Gani F, Crowley K, Lee K, Grant M, Zavadsky T, Hobson D, Wu C, Wick E, Pawlik T. Patient outcomes and provider perceptions following implementation of a standardized perioperative care pathway for open liver resection. British Journal Of Surgery 2016, 103: 564-571. PMID: 26859713, DOI: 10.1002/bjs.10087.Peer-Reviewed Original ResearchConceptsPost-ERAS groupPerioperative care pathwaysERAS pathwayOpen liver surgeryHospital stayPerioperative outcomesPostoperative complicationsOpioid useLiver surgeryCare pathwayProviders' perceptionsMean pain scoreOpen liver resectionShorter hospital stayImproved perioperative outcomesGroup of patientsCent of providersPerioperative pathwayPain scoresERAS programLiver resectionSurgery pathwayDisease characteristicsHepatic surgeryHospital costs
2009
A Randomized Clinical Trial Investigating the Relationship Between Aprotinin and Hypercoagulabilityin Off-Pump Coronary Surgery
Desai P, Kurian D, Thirumavalavan N, Desai S, Ziu P, Grant M, White C, Landis R, Poston R. A Randomized Clinical Trial Investigating the Relationship Between Aprotinin and Hypercoagulabilityin Off-Pump Coronary Surgery. Anesthesia & Analgesia 2009, 109: 1387-1394. PMID: 19843776, PMCID: PMC2789288, DOI: 10.1213/ane.0b013e3181b81068.Peer-Reviewed Original ResearchMeSH KeywordsAprotininBlood CoagulationBlood Coagulation TestsBlood PlateletsCoronary Artery Bypass, Off-PumpDouble-Blind MethodErythrocyte TransfusionFibrinolytic AgentsGraft Occlusion, VascularHumansPeptide FragmentsPlatelet AdhesivenessPlatelet AggregationPlatelet Function TestsPostoperative HemorrhageProspective StudiesProthrombinReceptor, PAR-1ThrombinThrombosisTreatment OutcomeWound HealingConceptsMajor adverse cardiovascular eventsProtease-activated receptor 1Adverse cardiovascular eventsSaphenous vein graftsCardiovascular eventsOPCAB surgeryAprotinin groupCoronary sinusHypercoagulable stateVein graftsThrombin generationAntifibrinolytic propertiesPump coronary artery bypass surgeryOff-pump coronary surgeryCoronary artery bypass surgeryRed blood cell transfusionAprotinin-treated patientsFull-dose regimenArtery bypass surgeryBlood cell transfusionCoronary sinus bloodPAR-1 antagonistsPlatelet-leukocyte conjugatesPAR-1 activationPlatelet-derived microparticles
2008
Is Aprotinin Safe to Use in a Cohort at Increased Risk for Thrombotic Events: Results From a Randomized, Prospective Trial in Off-Pump Coronary Artery Bypass
Grant M, Kon Z, Joshi A, Christenson E, Kallam S, Burris N, Gu J, Poston R. Is Aprotinin Safe to Use in a Cohort at Increased Risk for Thrombotic Events: Results From a Randomized, Prospective Trial in Off-Pump Coronary Artery Bypass. The Annals Of Thoracic Surgery 2008, 86: 815-822. PMID: 18721566, PMCID: PMC2649734, DOI: 10.1016/j.athoracsur.2008.04.047.Peer-Reviewed Original ResearchConceptsAcute kidney injuryCoronary artery bypassThrombotic eventsAprotinin levelsAprotinin useArtery bypassDay 3Off-pump coronary artery bypassMore acute kidney injuryPostoperative acute kidney injurySubsequent acute kidney injuryPump coronary artery bypassAcute graft failureAdverse thrombotic eventsWeight-based protocolPercentage of patientsGlomerular filtration rateFavorable safety profileMultiple randomized trialsPostoperative hypercoagulable stateEGFR declineCerebrovascular eventsKidney injuryLower eGFRPlacebo groupWarm ischemia provokes inflammation and regional hypercoagulability within the heart during off-pump coronary artery bypass: a possible target for serine protease inhibition
Kon Z, Brown E, Grant M, Ozeki T, Burris N, Collins M, Kwon M, Poston R. Warm ischemia provokes inflammation and regional hypercoagulability within the heart during off-pump coronary artery bypass: a possible target for serine protease inhibition. European Journal Of Cardio-Thoracic Surgery 2008, 33: 215-221. PMID: 18068996, PMCID: PMC2605708, DOI: 10.1016/j.ejcts.2007.11.008.Peer-Reviewed Original ResearchConceptsPump coronary artery bypassCoronary artery bypassTranscardiac gradientCoronary occlusionArtery bypassMyocardial ischemiaTNF-alphaCoronary sinus bloodEarly graft failureRegional myocardial ischemiaProthrombotic stateGraft failureProtamine administrationSinus bloodConsecutive patientsIschemic injuryMyocardial injuryIL-8Warm ischemiaPathophysiologic consequencesSeries of biomarkersCoagulation systemOPCABIschemiaInflammation