2022
Association between enrollment in an enhanced recovery program for colorectal cancer surgery and long‐term recurrence and survival
Zorrilla‐Vaca A, Ripolles‐Melchor J, Abad‐Motos A, Mingu I, Moreno‐Jurado N, Martínez‐Durán F, Pérez‐Martínez I, Abad‐Gurumeta A, FuenMayor‐Varela M, Mena G, Grant M. Association between enrollment in an enhanced recovery program for colorectal cancer surgery and long‐term recurrence and survival. Journal Of Surgical Oncology 2022, 125: 1269-1276. PMID: 35234283, DOI: 10.1002/jso.26836.Peer-Reviewed Original ResearchConceptsColorectal cancer surgeryCancer surgeryOncologic recurrenceColorectal cancerCancer stageCox hazard regression analysisMedian compliance rateSurgical inflammatory responseAdvanced colorectal cancerEnhanced recovery programmeOverall survival rateHazards regression analysisLong-term recurrenceAdvanced cancer stageERAS groupERAS interventionsERAS programOverall survivalMultivariable analysisSubgroup analysisInflammatory responseSurgery programLower riskEnhanced recoveryIntervention studies
2017
Relation between bispectral index measurements of anesthetic depth and postoperative mortality: a meta-analysis of observational studies
Zorrilla-Vaca A, Healy R, Wu C, Grant M. Relation between bispectral index measurements of anesthetic depth and postoperative mortality: a meta-analysis of observational studies. Journal Canadien D'anesthésie 2017, 64: 597-607. PMID: 28361391, DOI: 10.1007/s12630-017-0872-6.Peer-Reviewed Original ResearchConceptsDepth of anesthesiaLow bispectral indexObservational studyBispectral indexSubgroup analysisSignificant associationResultsEight observational studiesLong-term mortalityPooled effect sizeMain electronic databasesBispectral index measurementsRandom-effects modelPostoperative mortalityHazard ratioIntroductionThe associationRandomized trialsInclusion criteriaAnesthesiaElectronic databasesNarrative reviewPotential associationAnesthetic depthMethodsThe literatureMortalityAnesthesia depthImpact of Enhanced Recovery After Surgery and Fast Track Surgery Pathways on Healthcare-associated Infections
Grant M, Yang D, Wu C, Makary M, Wick E. Impact of Enhanced Recovery After Surgery and Fast Track Surgery Pathways on Healthcare-associated Infections. Annals Of Surgery 2017, 265: 68-79. PMID: 28009729, DOI: 10.1097/sla.0000000000001703.Peer-Reviewed Original ResearchConceptsHealthcare-associated infectionsSurgical site infectionUrinary tract infectionLung infectionFTS protocolFast-track surgery pathwaysFast-track surgery protocolMajor healthcare-associated infectionPostoperative lung infectionLength of staySignificant reductionPostoperative incidenceHospital lengthColorectal surgerySurgery protocolTract infectionsPerioperative carePrimary outcomeSite infectionRandomized trialsSurgery pathwayPelvic surgerySubgroup analysisSurgical careHigh risk
2016
The Effect of Preoperative Pregabalin on Postoperative Nausea and Vomiting
Grant M, Betz M, Hulse M, Zorrilla-Vaca A, Hobson D, Wick E, Wu C. The Effect of Preoperative Pregabalin on Postoperative Nausea and Vomiting. Anesthesia & Analgesia 2016, 123: 1100-1107. PMID: 27464972, DOI: 10.1213/ane.0000000000001404.Peer-Reviewed Original ResearchConceptsPreoperative pregabalinPostoperative nauseaPostoperative visual disturbancesPrevention of PONVSimilar antiemetic efficacyHigh-risk surgerySignificant reductionAdjuvant medicationsAntiemetic efficacyProphylactic antiemeticsThiopental inductionOpioid analgesiaPostoperative painSurgery protocolVisual disturbancesRandomized trialsRepeat dosingGeneral anesthesiaSubgroup analysisPregabalinEnhanced recoveryPONVNauseaVomitingTrialsThe Effect of Preoperative Gabapentin on Postoperative Nausea and Vomiting
Grant M, Lee H, Page A, Hobson D, Wick E, Wu C. The Effect of Preoperative Gabapentin on Postoperative Nausea and Vomiting. Anesthesia & Analgesia 2016, 122: 976-985. PMID: 26991615, DOI: 10.1213/ane.0000000000001120.Peer-Reviewed Original ResearchConceptsPreoperative gabapentinPrimary end pointEnd pointPostoperative nauseaSide effectsPrevention of PONVHigh-risk surgerySignificant reductionGabapentin administrationPostoperative sedationThiopental inductionOpioid analgesiaPostoperative painAntiemetic effectRepeat dosingGeneral anesthesiaSubgroup analysisPONVPooled effectNauseaVomitingGabapentinPrimary analysisSecondary analysisTrialsThe Effect of Intravenous Midazolam on Postoperative Nausea and Vomiting
Grant M, Kim J, Page A, Hobson D, Wick E, Wu C. The Effect of Intravenous Midazolam on Postoperative Nausea and Vomiting. Anesthesia & Analgesia 2016, 122: 656-663. PMID: 26332858, DOI: 10.1213/ane.0000000000000941.Peer-Reviewed Original ResearchConceptsPostoperative nauseaHigh-risk surgical patientsRescue antiemetic useUse of thiopentalHours of surgeryHigh-risk surgeryTrials of adultsMultimodal therapeutic approachIndividual subgroup analysisAntiemetic administrationAntiemetic useOverall PONVIntravenous midazolamSurgical patientsGeneral anesthesiaFemale sexSubgroup analysisPONVSurgical proceduresTherapeutic approachesNauseaVomitingMidazolamEnd pointTrialsThe Impact of Neuraxial Versus General Anesthesia on the Incidence of Postoperative Surgical Site Infections Following Knee or Hip Arthroplasty
Zorrilla-Vaca A, Grant MC, Mathur V, Li J, Wu CL. The Impact of Neuraxial Versus General Anesthesia on the Incidence of Postoperative Surgical Site Infections Following Knee or Hip Arthroplasty. Regional Anesthesia & Pain Medicine 2016, 41: 555-563. PMID: 27380106, DOI: 10.1097/aap.0000000000000437.Peer-Reviewed Original ResearchConceptsPostoperative surgical site infectionSurgical site infectionKnee arthroplastyHip arthroplastySite infectionNeuraxial anesthesiaGeneral anesthesiaSubgroup analysisOdds ratioDevelopment of SSIPooled unadjusted odds ratioUnadjusted odds ratioLarge observational trialsRandom-effects modelOverall beneficial effectObservational trialAnesthetic techniqueAnesthesia techniquesJoint arthroplastyInclusion criteriaTrial designArthroplastyMeta-AnalysisAnesthesiaPotential association