2019
Impact of Preoperative Erythropoietin on Allogeneic Blood Transfusions in Surgical Patients
Cho B, Serini J, Zorrilla-Vaca A, Scott M, Gehrie E, Frank S, Grant M. Impact of Preoperative Erythropoietin on Allogeneic Blood Transfusions in Surgical Patients. Anesthesia & Analgesia 2019, Publish Ahead of Print: &na;. PMID: 30649068, DOI: 10.1213/ane.0000000000004005.Peer-Reviewed Original ResearchConceptsRed blood cell transfusionAllogeneic blood transfusionBlood cell transfusionAllogeneic red blood cell transfusionPerioperative allogeneic blood transfusionBlood transfusionPreoperative erythropoietinCell transfusionThromboembolic eventsPatient blood management programPreoperative erythropoietin administrationSubset of patientsBlood management programPerioperative hemoglobin levelsErythropoietic stimulating agentsLength of stayErythropoietin useSecondary outcomesSurgical patientsThromboembolic complicationsBlood lossPrimary outcomeHemoglobin levelsRisk of exposureInpatient hospitalization
2009
A Randomized Clinical Trial Investigating the Relationship Between Aprotinin and Hypercoagulabilityin Off-Pump Coronary Surgery
Desai P, Kurian D, Thirumavalavan N, Desai S, Ziu P, Grant M, White C, Landis R, Poston R. A Randomized Clinical Trial Investigating the Relationship Between Aprotinin and Hypercoagulabilityin Off-Pump Coronary Surgery. Anesthesia & Analgesia 2009, 109: 1387-1394. PMID: 19843776, PMCID: PMC2789288, DOI: 10.1213/ane.0b013e3181b81068.Peer-Reviewed Original ResearchMeSH KeywordsAprotininBlood CoagulationBlood Coagulation TestsBlood PlateletsCoronary Artery Bypass, Off-PumpDouble-Blind MethodErythrocyte TransfusionFibrinolytic AgentsGraft Occlusion, VascularHumansPeptide FragmentsPlatelet AdhesivenessPlatelet AggregationPlatelet Function TestsPostoperative HemorrhageProspective StudiesProthrombinReceptor, PAR-1ThrombinThrombosisTreatment OutcomeWound HealingConceptsMajor adverse cardiovascular eventsProtease-activated receptor 1Adverse cardiovascular eventsSaphenous vein graftsCardiovascular eventsOPCAB surgeryAprotinin groupCoronary sinusHypercoagulable stateVein graftsThrombin generationAntifibrinolytic propertiesPump coronary artery bypass surgeryOff-pump coronary surgeryCoronary artery bypass surgeryRed blood cell transfusionAprotinin-treated patientsFull-dose regimenArtery bypass surgeryBlood cell transfusionCoronary sinus bloodPAR-1 antagonistsPlatelet-leukocyte conjugatesPAR-1 activationPlatelet-derived microparticles