2023
Dexmedetomidine improves pulmonary outcomes in thoracic surgery under one-lung ventilation: A meta-analysis
Zorrilla-Vaca A, Grant M, Law M, Messinger C, Pelosi P, Varelmann D. Dexmedetomidine improves pulmonary outcomes in thoracic surgery under one-lung ventilation: A meta-analysis. Journal Of Clinical Anesthesia 2023, 93: 111345. PMID: 37988813, PMCID: PMC11034816, DOI: 10.1016/j.jclinane.2023.111345.Peer-Reviewed Original ResearchAcute respiratory distress syndromePostoperative pulmonary complicationsOne-lung ventilationThoracic surgeryDexmedetomidine groupPlacebo groupPostoperative atelectasisRandomized trialsOdds ratioIncidence of PPCsImpact of dexmedetomidineIntraoperative respiratory mechanicsPostoperative lung functionRespiratory distress syndromeML/cmHRandom-effects modelPostoperative pneumoniaPulmonary complicationsPulmonary outcomesIntrapulmonary shuntPostoperative FEV1Secondary outcomesDistress syndromeLung functionPrimary outcomeUltrafiltration in cardiac surgery: Results of a systematic review and meta-analysis
Hensley N, Colao J, Zorrilla-Vaca A, Nanavati J, Lawton J, Raphael J, Mazzeffi M, Wierschke C, Kostibas M, Cho B, Frank S, Grant M. Ultrafiltration in cardiac surgery: Results of a systematic review and meta-analysis. Perfusion 2023, 39: 743-751. PMID: 36795704, DOI: 10.1177/02676591231157970.Peer-Reviewed Original ResearchIntraoperative red cell transfusionsRed cell transfusionAcute kidney injuryCell transfusionObservational studySystematic reviewConventional ultrafiltrationIntraoperative blood transfusionEffect of hemodilutionMeta-Analyses (PRISMA) statementPreferred Reporting ItemsRed cell unitsWeb of ScienceKidney injuryBlood transfusionCardiac surgeryModified ultrafiltrationPrimary outcomeCardiopulmonary bypassCochrane LibraryTransfusionElectrolyte balanceReporting ItemsCell unitsReviewPostoperative Hypoxemia After Dual-Controlled vs Volume-Controlled Ventilation in Lung Surgery
Zorrilla-Vaca A, Grant M, Rehman M, Sarin P, Varelmann D, Urman R. Postoperative Hypoxemia After Dual-Controlled vs Volume-Controlled Ventilation in Lung Surgery. The Annals Of Thoracic Surgery 2023, 116: 173-179. PMID: 36608756, DOI: 10.1016/j.athoracsur.2022.12.029.Peer-Reviewed Original ResearchConceptsLung resection surgeryPostoperative hypoxemiaResection surgeryPulmonary outcomesConventional ventilationAcute respiratory distress syndromeChronic obstructive pulmonary diseaseImproved pulmonary outcomesIntraoperative ventilator settingsPreoperative oxygen saturationSecondary pulmonary complicationsOne-lung ventilationObstructive pulmonary diseaseRespiratory distress syndromeLow tidal volumeVolume-controlled ventilationEligible patientsPRVC ventilationPulmonary complicationsRespiratory failureSecondary outcomesDistress syndromeLung surgeryPrimary outcomePulmonary disease
2022
Comparing Three Wearable Accelerometers to Measure Early Activity after Cardiac Surgery
Brown C, Yanek L, Healy R, Tsay T, Di J, Goeddel L, Young D, Zipunnikov V, Schrack J, Group C, Whitman G, Mandal K, Madeira T, Grant M, Hoyer E. Comparing Three Wearable Accelerometers to Measure Early Activity after Cardiac Surgery. JTCVS Open 2022, 11: 176-191. PMID: 36172447, PMCID: PMC9510817, DOI: 10.1016/j.xjon.2022.05.011.Peer-Reviewed Original ResearchHospital-based outcomesCardiac surgeryWearable activity monitorsPrimary outcomeNonhome locationActivity monitorCardiac surgery patientsDuration of hospitalizationSteps/dayAccelerometry monitorsClinical characteristicsCohort studySurgery patientsPostoperative activityProlonged hospitalizationWearable accelerometersPatient riskMobility ScaleSpectrum of characteristicsPatientsSurgeryAdditive valueOutcomesHospitalizationReadmissionEarly Return to Intended Oncologic Therapy after implementation of an Enhanced Recovery After Surgery pathway for gastric cancer surgery
Garcia-Nebreda M, Zorrilla-Vaca A, Ripollés-Melchor J, Abad-Motos A, Alvaro Cifuentes E, Abad-Gurumeta A, Mena G, Grant M, Paseiro-Crespo G. Early Return to Intended Oncologic Therapy after implementation of an Enhanced Recovery After Surgery pathway for gastric cancer surgery. Langenbeck's Archives Of Surgery 2022, 407: 2293-2300. PMID: 35441358, DOI: 10.1007/s00423-022-02515-7.Peer-Reviewed Original ResearchConceptsGastric cancer surgeryCancer surgeryERAS pathwayAdjuvant therapySurgery pathwayOncologic therapyGastric adenocarcinomaEnhanced recoveryPostoperative oncologic outcomesPre-ERAS periodERAS groupHospital stayOncologic outcomesPrimary outcomeShorter LOSResultsSeventy patientsEarly returnSurgeryIntervention studiesTherapyPatientsMedian differenceAdenocarcinomaOutcomesPathway
2021
Transesophageal Echocardiography in Patients Undergoing Coronary Artery Bypass Graft Surgery
Metkus T, Thibault D, Grant M, Badhwar V, Jacobs J, Lawton J, O'Brien S, Thourani V, Wegermann Z, Zwischenberger B, Higgins R. Transesophageal Echocardiography in Patients Undergoing Coronary Artery Bypass Graft Surgery. Journal Of The American College Of Cardiology 2021, 78: 112-122. PMID: 33957241, PMCID: PMC8876254, DOI: 10.1016/j.jacc.2021.04.064.Peer-Reviewed Original ResearchConceptsIntraoperative transesophageal echocardiographyHigh-risk patientsTransesophageal echocardiographyCABG patientsOperative mortalityValve proceduresCoronary artery bypass graft surgeryThoracic Surgeons Adult Cardiac Surgery DatabaseArtery bypass graft surgeryAdult Cardiac Surgery DatabasePost-CABG mortalityBypass graft surgeryCoronary artery bypassRetrospective cohort studyLow operative mortalityPercentage of patientsCardiac Surgery DatabaseClinical decision makingArtery bypassGraft surgeryValve surgeryCohort studyCABG proceduresPrimary outcomeSurgery Database
2020
Retrograde Autologous Priming in Cardiac Surgery: Results From a Systematic Review and Meta-analysis.
Hensley N, Gyi R, Zorrilla-Vaca A, Choi C, Lawton J, Brown C, Frank S, Grant M, Cho B. Retrograde Autologous Priming in Cardiac Surgery: Results From a Systematic Review and Meta-analysis. Anesthesia & Analgesia 2020, 132: 100-107. PMID: 32947294, DOI: 10.1213/ane.0000000000005151.Peer-Reviewed Original ResearchConceptsAllogeneic red cell transfusionRed cell transfusionAcute kidney injuryCardiac surgical patientsCell transfusionCardiopulmonary bypassObservational studySystematic reviewAutologous primingRAP patientsSurgical patientsCardiac surgeryAdditional high-quality prospective studiesPerioperative allogeneic red cell transfusionIntraoperative red cell transfusionsHigh-quality prospective studiesSignificant increased oddsAllogeneic transfusionKidney injuryAdverse eventsControl patientsSecondary outcomesStroke outcomeOrgan injuryPrimary outcome
2019
Perioperative Dextrose Infusion and Postoperative Nausea and Vomiting
Zorrilla-Vaca A, Marmolejo-Posso D, Stone A, Li J, Grant MC. Perioperative Dextrose Infusion and Postoperative Nausea and Vomiting. Anesthesia & Analgesia 2019, Publish Ahead of Print: &na;. PMID: 30649067, DOI: 10.1213/ane.0000000000004019.Peer-Reviewed Original ResearchConceptsPostoperative nauseaDextrose infusionAntiemetic administrationGlucose levelsPlasma glucose monitoringPostoperative antiemetic administrationRescue antiemetic requirementsFurther prospective trialsPostanesthesia care unitSerum glucose levelsPlasma glucose levelsSignificant reductionAntiemetic requirementsPostoperative hyperglycemiaProspective trialSecondary outcomesPostoperative infusionPrimary outcomeCare unitCochrane LibraryUse of dextroseNauseaVomitingInfusionSignificant associationImpact of Preoperative Erythropoietin on Allogeneic Blood Transfusions in Surgical Patients
Cho B, Serini J, Zorrilla-Vaca A, Scott M, Gehrie E, Frank S, Grant M. Impact of Preoperative Erythropoietin on Allogeneic Blood Transfusions in Surgical Patients. Anesthesia & Analgesia 2019, Publish Ahead of Print: &na;. PMID: 30649068, DOI: 10.1213/ane.0000000000004005.Peer-Reviewed Original ResearchConceptsRed blood cell transfusionAllogeneic blood transfusionBlood cell transfusionAllogeneic red blood cell transfusionPerioperative allogeneic blood transfusionBlood transfusionPreoperative erythropoietinCell transfusionThromboembolic eventsPatient blood management programPreoperative erythropoietin administrationSubset of patientsBlood management programPerioperative hemoglobin levelsErythropoietic stimulating agentsLength of stayErythropoietin useSecondary outcomesSurgical patientsThromboembolic complicationsBlood lossPrimary outcomeHemoglobin levelsRisk of exposureInpatient hospitalization
2018
Intraoperative cerebral oximetry-based management for optimizing perioperative outcomes: a meta-analysis of randomized controlled trials
Zorrilla-Vaca A, Healy R, Grant M, Joshi B, Rivera-Lara L, Brown C, Mirski M. Intraoperative cerebral oximetry-based management for optimizing perioperative outcomes: a meta-analysis of randomized controlled trials. Journal Canadien D'anesthésie 2018, 65: 529-542. PMID: 29427259, DOI: 10.1007/s12630-018-1065-7.Peer-Reviewed Original ResearchConceptsPostoperative cognitive dysfunctionIntensive care unitIntraoperative cerebral oximetryCerebral oximetryPostoperative deliriumIncidence of POCDProspective clinical trialsOverall hospital LOSPredictors of outcomeGoogle Scholar databasesHospital LOSPurposeAlthough evidenceHospital lengthPerioperative outcomesPostoperative outcomesSecondary outcomesPrimary outcomeCare unitClinical outcomesIntraoperative managementLarge RCTsCochrane LibraryClinical trialsCognitive dysfunctionObservational study
2017
Impact of Enhanced Recovery After Surgery and Fast Track Surgery Pathways on Healthcare-associated Infections
Grant M, Yang D, Wu C, Makary M, Wick E. Impact of Enhanced Recovery After Surgery and Fast Track Surgery Pathways on Healthcare-associated Infections. Annals Of Surgery 2017, 265: 68-79. PMID: 28009729, DOI: 10.1097/sla.0000000000001703.Peer-Reviewed Original ResearchConceptsHealthcare-associated infectionsSurgical site infectionUrinary tract infectionLung infectionFTS protocolFast-track surgery pathwaysFast-track surgery protocolMajor healthcare-associated infectionPostoperative lung infectionLength of staySignificant reductionPostoperative incidenceHospital lengthColorectal surgerySurgery protocolTract infectionsPerioperative carePrimary outcomeSite infectionRandomized trialsSurgery pathwayPelvic surgerySubgroup analysisSurgical careHigh risk