2020
Goal-Directed Fluid Therapy and Postoperative Outcomes in an Enhanced Recovery Program for Colorectal Surgery: A Propensity Score-Matched Multicenter Study
Zorrilla-Vaca A, Mena G, Ripolles-Melchor J, Abad-Motos A, Aldecoa C, Lorente J, Ramirez-Rodriguez J, Grant M. Goal-Directed Fluid Therapy and Postoperative Outcomes in an Enhanced Recovery Program for Colorectal Surgery: A Propensity Score-Matched Multicenter Study. The American Surgeon 2020, 87: 1189-1195. PMID: 33342254, DOI: 10.1177/0003134820973365.Peer-Reviewed Original ResearchConceptsGoal-directed fluid therapyEnhanced recovery programmeAcute kidney injurySurgical site infectionColorectal surgeryPostoperative outcomesFluid therapyPostoperative acute kidney injuryPropensity score-matched analysisComparable baseline demographicsMajor postoperative outcomesAdequate tissue perfusionRates of morbidityHospital stayKidney injuryBaseline demographicsCohort studyConventional careERAS programAnastomotic dehiscenceMajor surgerySite infectionPulmonary edemaMulticenter studyTherapy patientsOpioid-Sparing Cardiac Anesthesia: Secondary Analysis of an Enhanced Recovery Program for Cardiac Surgery.
Grant M, Isada T, Ruzankin P, Gottschalk A, Whitman G, Lawton J, Dodd-O J, Barodka V. Opioid-Sparing Cardiac Anesthesia: Secondary Analysis of an Enhanced Recovery Program for Cardiac Surgery. Anesthesia & Analgesia 2020, 131: 1852-1861. PMID: 32889848, DOI: 10.1213/ane.0000000000005152.Peer-Reviewed Original ResearchConceptsIntraoperative opioid administrationEnhanced recovery programmeOpioid administrationCardiac surgeryNonopioid interventionsPostoperative outcomesNumber of interventionsOpioid patientsSecondary analysisSerratus anterior plane blockMorphine sulfate equivalentsOpioid-sparing strategiesPostoperative pain scoresFuture prospective studiesLength of stayLinear mixed-effects regression modelsMixed-effects regression modelsIntraoperative dexmedetomidineLower opioidPreoperative gabapentinMultimodal analgesiaPain scoresPostoperative complicationsOpioid usePlane block
2019
Opioid tolerance impacts compliance with enhanced recovery pathway after major abdominal surgery
Owodunni O, Zaman M, Ighani M, Grant M, Bettick D, Sateri S, Magnuson T, Gearhart S. Opioid tolerance impacts compliance with enhanced recovery pathway after major abdominal surgery. Surgery 2019, 166: 1055-1060. PMID: 31526584, DOI: 10.1016/j.surg.2019.08.001.Peer-Reviewed Original ResearchConceptsEnhanced recovery pathwayMajor abdominal surgeryOpioid-tolerant patientsOpioid toleranceAbdominal surgeryLength of stayTolerant patientsRecovery pathwaysPostoperative outcomesMajor complicationsPathway complianceChallenging patient cohortNon-tolerant patientsPoor postoperative outcomesOperative Severity ScoreEnUmeration of MortalityRisk-adjusted analysisPrescribed opioid medicationsOutcomes of interestEvidence-based interventionsColorectal PhysiologicalOral morphineOpioid medicationsEmergency surgeryReadmission ratesAnesthesia for Spine Surgery
Zorrilla-Vaca A, Grant M, Mirski M. Anesthesia for Spine Surgery. 2019, 189-200. DOI: 10.1007/978-981-13-3387-3_14.Peer-Reviewed Original ResearchSpine surgeryMultimodal analgesic strategyIntraoperative blood lossLumbar spine surgeryLength of stayManagement of anesthesiaPatient-focused approachAnalgesic strategiesHospital stayPostoperative complicationsPostoperative nauseaPostoperative painPostoperative outcomesAnesthetic managementBlood lossAnesthetic techniqueGeneral anesthesiaIntraoperative stabilityPerioperative assessmentOptimal anesthesiaRegional anesthesiaRegional techniquesSurgery programSurgeryAnesthesia
2018
Intraoperative cerebral oximetry-based management for optimizing perioperative outcomes: a meta-analysis of randomized controlled trials
Zorrilla-Vaca A, Healy R, Grant M, Joshi B, Rivera-Lara L, Brown C, Mirski M. Intraoperative cerebral oximetry-based management for optimizing perioperative outcomes: a meta-analysis of randomized controlled trials. Journal Canadien D'anesthésie 2018, 65: 529-542. PMID: 29427259, DOI: 10.1007/s12630-018-1065-7.Peer-Reviewed Original ResearchConceptsPostoperative cognitive dysfunctionIntensive care unitIntraoperative cerebral oximetryCerebral oximetryPostoperative deliriumIncidence of POCDProspective clinical trialsOverall hospital LOSPredictors of outcomeGoogle Scholar databasesHospital LOSPurposeAlthough evidenceHospital lengthPerioperative outcomesPostoperative outcomesSecondary outcomesPrimary outcomeCare unitClinical outcomesIntraoperative managementLarge RCTsCochrane LibraryClinical trialsCognitive dysfunctionObservational study