2024
Impact of Nighttime Cardiovascular Intensive Care Unit Staffing on Failure to Rescue and Revenue
Kang J, Holmes S, Rando H, Chinedozi I, Darby Z, Briscoe J, Grant M, Whitman G. Impact of Nighttime Cardiovascular Intensive Care Unit Staffing on Failure to Rescue and Revenue. The Annals Of Thoracic Surgery 2024 PMID: 39481824, DOI: 10.1016/j.athoracsur.2024.10.014.Peer-Reviewed Original ResearchEra 1Era 2Cardiac surgeryRelative value unitsFTR ratesPost-cardiotomy patientsMajor complicationsComplication ratePostoperative complicationsAnnual relative value unitsMultivariate analysisNighttime intensivist staffingComplicationsIntensive care unit staffingPatientsIntensivist staffingICU censusSurgeryICUMortalityValue unitsFiscal yearRiskUnit staffingFTRMaximizing Minimally Invasive Cardiac Surgery With Enhanced Recovery (ERAS)
Salenger R, Ad N, Grant M, Bakaeen F, Balkhy H, Mick S, Nia P, Kempfert J, Bonaros N, Bapat V, von Ballmoos M, Gerdisch M, Johnston D, Engelman D. Maximizing Minimally Invasive Cardiac Surgery With Enhanced Recovery (ERAS). Innovations Technology And Techniques In Cardiothoracic And Vascular Surgery 2024, 19: 371-379. PMID: 39205530, DOI: 10.1177/15569845241264565.Peer-Reviewed Original ResearchMinimally invasive cardiac surgeryInvasive cardiac surgeryCardiac surgeryPerioperative carePreservation of cardiac functionManagement of hemodynamicsGroup of cardiac surgeonsEnhanced recoveryComprehensive perioperative careCardiac surgeonsCardiac functionSurgical incisionERAS programSurgical goalsMyocardial managementSurgeryTissue invasionIncisionPatientsTelehealth and Outcomes in Patients With Cancer
Grant M, Chiang A. Telehealth and Outcomes in Patients With Cancer. The Cancer Journal 2024, 30: 16-21. PMID: 38265921, DOI: 10.1097/ppo.0000000000000697.Peer-Reviewed Original ResearchConceptsCost-effective care deliveryDelivery of oncology careCare delivery mechanismsIn-person careEffectiveness of telehealthPatient-centered outcomesQuality of lifeCare deliveryCancer abstractsCancer careOncology careReduce disparitiesFinancial toxicityIn-personTelehealthPatient satisfactionCareCOVID-19 pandemicOutcomesCancerEfficacy endpointPatientsDeliveryCOVID-19Disparities
2023
Perioperative hemodynamic monitoring in cardiac surgery
Grant M, Salenger R, Lobdell K. Perioperative hemodynamic monitoring in cardiac surgery. Current Opinion In Anaesthesiology 2023, 37: 1-9. PMID: 38085877, DOI: 10.1097/aco.0000000000001327.Peer-Reviewed Original ResearchConceptsPulmonary artery catheterCardiac surgeryArtery catheterHemodynamic monitoringInvasive alternativeLow-risk cardiac surgeryInvasive hemodynamic monitoringLow-risk patientsPerioperative hemodynamic monitoringPulse contour analysisPatient's hemodynamicsResuscitation therapyBedside cliniciansInvasive approachInvasive monitoringRecent studiesSurgeryMonitoring modalitiesQuestionable benefitCatheterRegular useBroader indicationsPatientsSelective useUseful alternativePerformance Comparison of Pulmonary Risk Scoring Systems in Lung Resection
Zorrilla-Vaca A, Grant M, Rehman M, Sarin P, Mendez-Pino L, Urman R, Varelmann D. Performance Comparison of Pulmonary Risk Scoring Systems in Lung Resection. Journal Of Cardiothoracic And Vascular Anesthesia 2023, 37: 1734-1743. PMID: 37330329, DOI: 10.1053/j.jvca.2023.05.035.Peer-Reviewed Original ResearchConceptsPostoperative pulmonary complicationsLung resection surgeryRisk-scoring systemPulmonary complicationsResection surgeryScoring systemLung resectionRisk scoreRisk of PPCsRetrospective cohort study SETTINGLAS VEGASAlternative risk scoresSingle-center cohortCohort study SETTINGAdult patientsExpiratory volumeLung surgeryThoracic surgeryPulmonary riskConcordance indexSurgeryPatientsDiscriminatory powerStudy settingComplicationsThe Evolving Role for Systemic Therapy in Resectable Non-small Cell Lung Cancer
Grant M, Woodard G, Goldberg S. The Evolving Role for Systemic Therapy in Resectable Non-small Cell Lung Cancer. Hematology/Oncology Clinics Of North America 2023, 37: 513-531. PMID: 37024389, DOI: 10.1016/j.hoc.2023.02.003.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerCell lung cancerLung cancerMetastatic non-small cell lung cancerResectable non-small cell lung cancerImmuno-oncology agentsHistologic classification systemUnited States FoodResectable tumorsSystemic therapyDriver alterationsDrug AdministrationStates FoodSystemic managementPatientsTherapyCancerEvolving roleClassification systemNTRKHER2TumorsKRASEGFRBRAFEfficacy of Osimertinib in Patients with Lung Cancer Positive for Uncommon EGFR Exon 19 Deletion Mutations
Grant M, Aredo J, Starrett J, Stockhammer P, van Rosenburgh I, Wurtz A, Piper-Valillo A, Piotrowska Z, Falcon C, Yu H, Aggarwal C, Scholes D, Patil T, Nguyen C, Phadke M, Li F, Neal J, Lemmon M, Walther Z, Politi K, Goldberg S. Efficacy of Osimertinib in Patients with Lung Cancer Positive for Uncommon EGFR Exon 19 Deletion Mutations. Clinical Cancer Research 2023, 29: of1-of8. PMID: 36913537, PMCID: PMC10493186, DOI: 10.1158/1078-0432.ccr-22-3497.Peer-Reviewed Original ResearchConceptsProgression-free survivalNon-small cell lung cancerInferior progression-free survivalMulticenter retrospective cohortEfficacy of osimertinibMulti-institutional cohortCell lung cancerExon 19 deletion mutationUncommon EGFRRetrospective cohortClinical outcomesClinical efficacyLung cancerOsimertinib efficacyEGFR mutationsPreclinical modelsEx19delPatientsAACR Genie databaseLater linesOsimertinibMutant cohortFirst lineCohortEfficacy
2022
Comparing Three Wearable Accelerometers to Measure Early Activity after Cardiac Surgery
Brown C, Yanek L, Healy R, Tsay T, Di J, Goeddel L, Young D, Zipunnikov V, Schrack J, Group C, Whitman G, Mandal K, Madeira T, Grant M, Hoyer E. Comparing Three Wearable Accelerometers to Measure Early Activity after Cardiac Surgery. JTCVS Open 2022, 11: 176-191. PMID: 36172447, PMCID: PMC9510817, DOI: 10.1016/j.xjon.2022.05.011.Peer-Reviewed Original ResearchHospital-based outcomesCardiac surgeryWearable activity monitorsPrimary outcomeNonhome locationActivity monitorCardiac surgery patientsDuration of hospitalizationSteps/dayAccelerometry monitorsClinical characteristicsCohort studySurgery patientsPostoperative activityProlonged hospitalizationWearable accelerometersPatient riskMobility ScaleSpectrum of characteristicsPatientsSurgeryAdditive valueOutcomesHospitalizationReadmissionEarly Return to Intended Oncologic Therapy after implementation of an Enhanced Recovery After Surgery pathway for gastric cancer surgery
Garcia-Nebreda M, Zorrilla-Vaca A, Ripollés-Melchor J, Abad-Motos A, Alvaro Cifuentes E, Abad-Gurumeta A, Mena G, Grant M, Paseiro-Crespo G. Early Return to Intended Oncologic Therapy after implementation of an Enhanced Recovery After Surgery pathway for gastric cancer surgery. Langenbeck's Archives Of Surgery 2022, 407: 2293-2300. PMID: 35441358, DOI: 10.1007/s00423-022-02515-7.Peer-Reviewed Original ResearchConceptsGastric cancer surgeryCancer surgeryERAS pathwayAdjuvant therapySurgery pathwayOncologic therapyGastric adenocarcinomaEnhanced recoveryPostoperative oncologic outcomesPre-ERAS periodERAS groupHospital stayOncologic outcomesPrimary outcomeShorter LOSResultsSeventy patientsEarly returnSurgeryIntervention studiesTherapyPatientsMedian differenceAdenocarcinomaOutcomesPathwayEnhanced Recovery for Cardiac Surgery
Gregory A, Grant M, Fletcher N. Enhanced Recovery for Cardiac Surgery. 2022, 421-433. DOI: 10.1007/978-3-030-79721-8_32.Peer-Reviewed Original ResearchCardiac surgeryEnhanced recoveryClass of recommendationLevel of evidenceComprehensive systematic reviewHealth care resourcesFormal Delphi processPerioperative careOutcome measuresCurrent recommendationsPatient experienceCare resourcesRecovery programSurgerySystematic reviewStudy designDelphi processMultidisciplinary groupHealthcare systemFurther studiesComplicationsPatientsCardiacRecommendationsCarePatient Characteristics Influencing Adherence to Enhanced Recovery Protocols for Colorectal Surgery: a Multicentric Prospective Study
Galarza-Prado A, Zorrilla-Vaca A, Healy R, Ripollés J, Abad-Motos A, Nozal-Mateo B, Del Rio S, Caballero-Lozada A, Stone A, Mena G, Grant M. Patient Characteristics Influencing Adherence to Enhanced Recovery Protocols for Colorectal Surgery: a Multicentric Prospective Study. Journal Of Gastrointestinal Surgery 2022, 26: 911-916. PMID: 35059982, DOI: 10.1007/s11605-021-05234-4.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseColorectal surgeryPreoperative hypoalbuminemiaPreoperative transfusionPatient characteristicsArtery diseaseHigh adherenceRecovery protocolMultivariable logistic regression analysisEnhanced recovery protocolMulticentric prospective studyLow complication rateLogistic regression analysisClinical characteristicsComplication rateMetastatic diseaseSurgical characteristicsCancer resectionSurgery guidelinesProspective studyAdequate adherenceUnivariate analysisLow adherenceMultivariable modelPatients
2021
Putting the 2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization Into Practice A Case Series
Bittl J, Bangalore S, DiMaio J, Grant M, Lawton J, Holland J. Putting the 2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization Into Practice A Case Series. JACC Case Reports 2021, 4: 31-35. PMID: 35036940, PMCID: PMC8743811, DOI: 10.1016/j.jaccas.2021.09.025.Peer-Reviewed Original ResearchACC/AHA/SCAI GuidelineCoronary artery revascularizationArtery revascularizationCase seriesStable ischemic heart diseaseA Case SeriesOptimal medical therapyComplex coronary diseaseSubset of patientsIschemic heart diseaseCardiovascular eventsVentricular dysfunctionCoronary diseaseMedical therapyHeart diseaseRevascularizationDiseaseGuidelinesPatientsDysfunctionTherapyMortalityImmune Therapy: What Can We Learn From Acquired Resistance?
Grant M, Politi K, Gettinger S. Immune Therapy: What Can We Learn From Acquired Resistance? Current Cancer Research 2021, 75-114. DOI: 10.1007/978-3-030-74028-3_5.ChaptersNon-small cell lung cancerAdvanced non-small cell lung cancerDeath-1 pathway inhibitorsPD-1 axis inhibitorsInitial tumor regressionCell lung cancerImmune checkpoint pathwaysIFN-γ signalingMediators of resistanceDisease stabilitySystemic progressionMost patientsLocal therapyClinical criteriaLung cancerTumor regressionTumor typesDisease sitesPathway inhibitorAcquired ResistancePresentation defectPatientsTranslational workProgressionEpigenetic changesPerioperative Coronavirus Vaccination—Timing and Implications: A Guidance Document
Merritt-Genore H, Moosdorf R, Gillaspie E, Lother S, Engelman D, Ahmed S, Baciewicz FA, Grant MC, Milewski R, Cawcutt K, Hayanga JA, Chatterjee S, Arora RC, Care S. Perioperative Coronavirus Vaccination—Timing and Implications: A Guidance Document. The Annals Of Thoracic Surgery 2021, 112: 1707-1715. PMID: 34370980, PMCID: PMC8349423, DOI: 10.1016/j.athoracsur.2021.07.016.Peer-Reviewed Original Research
2020
Cardiac Surgery-Enhanced Recovery Programs Modified for COVID-19: Key Steps to Preserve Resources, Manage Caseload Backlog, and Improve Patient Outcomes
Gregory A, Grant M, Boyle E, Arora R, Williams J, Salenger R, Chatterjee S, Lobdell K, Jahangiri M, Engelman D. Cardiac Surgery-Enhanced Recovery Programs Modified for COVID-19: Key Steps to Preserve Resources, Manage Caseload Backlog, and Improve Patient Outcomes. Journal Of Cardiothoracic And Vascular Anesthesia 2020, 34: 3218-3224. PMID: 32888804, PMCID: PMC7416680, DOI: 10.1053/j.jvca.2020.08.007.Peer-Reviewed Original ResearchConceptsCardiac surgeryCOVID-19 careCOVID-19 pandemicEvidence-based measuresCurrent healthcare climatePerioperative carePatient outcomesProvider safetyPatient experienceEnhanced recoveryHigh-quality healthcareRecovery programPatient careSurgeryHospital capacityHealthcare climateMulti-disciplinary groupCareCOVID-19Supportive evidenceOutcomesCOVID-19 environmentPandemicPatientsRamping Up Delivery of Cardiac Surgery During the COVID-19 Pandemic: A Guidance Statement From The Society of Thoracic Surgeons COVID-19 Task Force
Engelman D, Lother S, George I, Ailawadi G, Atluri P, Grant M, Haft J, Hassan A, Legare J, Whitman G, Arora R, Surgery S. Ramping Up Delivery of Cardiac Surgery During the COVID-19 Pandemic: A Guidance Statement From The Society of Thoracic Surgeons COVID-19 Task Force. The Annals Of Thoracic Surgery 2020, 110: 712-717. PMID: 32407853, PMCID: PMC7215160, DOI: 10.1016/j.athoracsur.2020.05.002.Peer-Reviewed Original ResearchConceptsCOVID-19 pandemic burdenSurgical programsHigh-risk anatomyUrgent operative proceduresCoronavirus disease 2019 (COVID-19) pandemicHealthcare systemCardiac surgical programsHealthcare deliveryDisease 2019 pandemicPublic health restrictionsCOVID-19 Task ForceCardiac surgeryClinical statusElective proceduresCOVID-19 casesPandemic burdenHealthcare workersOperative procedureSurgical proceduresRapid transmissibilityCase volumePandemic surgeGuidance statementsPatientsCare deliveryAdult cardiac surgery and the COVID-19 pandemic: Aggressive infection mitigation strategies are necessary in the operating room and surgical recovery
Engelman D, Lother S, George I, Funk D, Ailawadi G, Atluri P, Grant M, Haft J, Hassan A, Legare J, Whitman G, Arora R, Force T. Adult cardiac surgery and the COVID-19 pandemic: Aggressive infection mitigation strategies are necessary in the operating room and surgical recovery. Journal Of Thoracic And Cardiovascular Surgery 2020, 160: 447-451. PMID: 32689700, PMCID: PMC7185923, DOI: 10.1016/j.jtcvs.2020.04.059.Peer-Reviewed Original ResearchMeSH KeywordsBetacoronavirusCardiac Surgical ProceduresConsensusCoronavirus InfectionsCOVID-19Cross InfectionHeart DiseasesHumansInfection ControlInfectious Disease Transmission, Patient-to-ProfessionalInfectious Disease Transmission, Professional-to-PatientOccupational HealthOperating RoomsPandemicsPatient SafetyPneumonia, ViralRecovery RoomRisk AssessmentRisk FactorsSARS-CoV-2VirulenceAdult Cardiac Surgery and the COVID-19 Pandemic: Aggressive Infection Mitigation Strategies Are Necessary in the Operating Room and Surgical Recovery
Engelman D, Lother S, George I, Funk D, Ailawadi G, Atluri P, Grant M, Haft J, Hassan A, Legare J, Whitman G, Arora R, Force T. Adult Cardiac Surgery and the COVID-19 Pandemic: Aggressive Infection Mitigation Strategies Are Necessary in the Operating Room and Surgical Recovery. The Annals Of Thoracic Surgery 2020, 110: 707-711. PMID: 32353440, PMCID: PMC7185911, DOI: 10.1016/j.athoracsur.2020.04.007.Peer-Reviewed Original ResearchAdult cardiac surgery during the COVID-19 pandemic: A tiered patient triage guidance statement
Haft J, Atluri P, Ailawadi G, Engelman D, Grant M, Hassan A, Legare J, Whitman G, Arora R, Surgery T. Adult cardiac surgery during the COVID-19 pandemic: A tiered patient triage guidance statement. Journal Of Thoracic And Cardiovascular Surgery 2020, 160: 452-455. PMID: 32689701, PMCID: PMC7161470, DOI: 10.1016/j.jtcvs.2020.04.011.Peer-Reviewed Original ResearchMeSH KeywordsBetacoronavirusCardiac Surgical ProceduresConsensusCoronavirus InfectionsCOVID-19Cross InfectionHeart DiseasesHumansInfection ControlInfectious Disease Transmission, Patient-to-ProfessionalInfectious Disease Transmission, Professional-to-PatientOccupational HealthPandemicsPatient SafetyPneumonia, ViralRisk AssessmentRisk FactorsSARS-CoV-2TriageVirulenceConceptsCardiac surgeonsAdult cardiac surgeryCardiac surgery teamAdult cardiac surgeonsCardiac surgeryPatient assessmentCurrent novel coronavirus pandemicSurgery teamGuidance statementsNovel coronavirus pandemicMedical communityCOVID-19 pandemicInterdisciplinary teamSurgeonsPandemicOutpatientsPatientsSurgeryPhysiciansAdult Cardiac Surgery During the COVID-19 Pandemic: A Tiered Patient Triage Guidance Statement
Haft J, Atluri P, Ailawadi G, Engelman D, Grant M, Hassan A, Legare J, Whitman G, Arora R, Surgery S. Adult Cardiac Surgery During the COVID-19 Pandemic: A Tiered Patient Triage Guidance Statement. The Annals Of Thoracic Surgery 2020, 110: 697-700. PMID: 32305286, PMCID: PMC7161520, DOI: 10.1016/j.athoracsur.2020.04.003.Peer-Reviewed Original ResearchConceptsCardiac surgeonsAdult cardiac surgeryCardiac surgery teamAdult cardiac surgeonsCardiac surgeryPatient assessmentCurrent novel coronavirus pandemicSurgery teamGuidance statementsNovel coronavirus pandemicMedical communityCOVID-19 pandemicInterdisciplinary teamSurgeonsPandemicOutpatientsPatientsSurgeryPhysicians