2024
Preoperative Multivariable Model for Risk Stratification of Hypoxemia During One-Lung Ventilation
Zorrilla-Vaca A, Grant M, Mendez-Pino L, Rehman M, Sarin P, Nasra S, Varelmann D. Preoperative Multivariable Model for Risk Stratification of Hypoxemia During One-Lung Ventilation. Anesthesia & Analgesia 2024 DOI: 10.1213/ane.0000000000007306.Peer-Reviewed Original ResearchOne-lung ventilationArea under the receiver operating curveRisk of hypoxemiaIntraoperative hypoxemiaRisk stratificationClinical variablesRisk of intraoperative hypoxemiaEpisodes of oxygen desaturationBody mass index >Preoperative clinical variablesStratification modelLung perfusion scanElective lung surgeryLateral decubitus positionPositive predictive valueRetrospective cohort studyCongestive heart failureHighest Youden indexPreoperative multivariable modelLogistic regressionRisk stratification modelRight-sided surgeryMultivariate logistic regressionIncidence of hypoxemiaDouble lumen tube
2023
Dexmedetomidine improves pulmonary outcomes in thoracic surgery under one-lung ventilation: A meta-analysis
Zorrilla-Vaca A, Grant M, Law M, Messinger C, Pelosi P, Varelmann D. Dexmedetomidine improves pulmonary outcomes in thoracic surgery under one-lung ventilation: A meta-analysis. Journal Of Clinical Anesthesia 2023, 93: 111345. PMID: 37988813, PMCID: PMC11034816, DOI: 10.1016/j.jclinane.2023.111345.Peer-Reviewed Original ResearchAcute respiratory distress syndromePostoperative pulmonary complicationsOne-lung ventilationThoracic surgeryDexmedetomidine groupPlacebo groupPostoperative atelectasisRandomized trialsOdds ratioIncidence of PPCsImpact of dexmedetomidineIntraoperative respiratory mechanicsPostoperative lung functionRespiratory distress syndromeML/cmHRandom-effects modelPostoperative pneumoniaPulmonary complicationsPulmonary outcomesIntrapulmonary shuntPostoperative FEV1Secondary outcomesDistress syndromeLung functionPrimary outcomePostoperative Hypoxemia After Dual-Controlled vs Volume-Controlled Ventilation in Lung Surgery
Zorrilla-Vaca A, Grant M, Rehman M, Sarin P, Varelmann D, Urman R. Postoperative Hypoxemia After Dual-Controlled vs Volume-Controlled Ventilation in Lung Surgery. The Annals Of Thoracic Surgery 2023, 116: 173-179. PMID: 36608756, DOI: 10.1016/j.athoracsur.2022.12.029.Peer-Reviewed Original ResearchConceptsLung resection surgeryPostoperative hypoxemiaResection surgeryPulmonary outcomesConventional ventilationAcute respiratory distress syndromeChronic obstructive pulmonary diseaseImproved pulmonary outcomesIntraoperative ventilator settingsPreoperative oxygen saturationSecondary pulmonary complicationsOne-lung ventilationObstructive pulmonary diseaseRespiratory distress syndromeLow tidal volumeVolume-controlled ventilationEligible patientsPRVC ventilationPulmonary complicationsRespiratory failureSecondary outcomesDistress syndromeLung surgeryPrimary outcomePulmonary disease