2024
Protective mechanical ventilation in critically ill patients after surgery
Zorrilla-Vaca A, Arevalo J, Grant M. Protective mechanical ventilation in critically ill patients after surgery. Current Opinion In Critical Care 2024, 30: 679-683. PMID: 39503212, DOI: 10.1097/mcc.0000000000001215.Peer-Reviewed Original ResearchIntensive care unitVentilator-induced lung injuryLung protective strategyCritically ill patientsMechanical ventilationCare unitLung injurySurgical patientsFast-track extubation protocolOpen-lung ventilation strategyIll patientsRisk of ventilator-induced lung injuryHigh-flow nasal cannulaHigh-risk surgical patientsOpen lung ventilationOperating roomNoninvasive ventilation supportProtective mechanical ventilationPositive-end expiratory pressureAcute lung injuryMechanically ventilated patientsStandard of careThoracic surgeryNasal cannulaRetrospective study
2022
Individualised positive end-expiratory pressure in abdominal surgery: a systematic review and meta-analysis
Zorrilla-Vaca A, Grant M, Urman R, Frendl G. Individualised positive end-expiratory pressure in abdominal surgery: a systematic review and meta-analysis. British Journal Of Anaesthesia 2022, 129: 815-825. PMID: 36031417, DOI: 10.1016/j.bja.2022.07.009.Peer-Reviewed Original ResearchConceptsPositive end-expiratory pressureEnd-expiratory pressurePulmonary complicationsAbdominal surgerySystemic inflammationRisk ratioAcute respiratory distress syndromeLaird random-effects modelOverall pulmonary complicationsPostoperative pulmonary outcomesComposite primary outcomeEnd of surgerySystemic inflammatory markersRespiratory distress syndromeConfidence intervalsRandom-effects modelPostoperative atelectasisPrimary endpointPulmonary outcomesCochrane riskInflammatory markersLung injuryPostoperative hypoxaemiaSecondary outcomesBias tool
2016
A Meta-analysis of Intraoperative Ventilation Strategies to Prevent Pulmonary Complications
Yang D, Grant M, Stone A, Wu C, Wick E. A Meta-analysis of Intraoperative Ventilation Strategies to Prevent Pulmonary Complications. Annals Of Surgery 2016, 263: 881-887. PMID: 26720429, DOI: 10.1097/sla.0000000000001443.Peer-Reviewed Original ResearchConceptsPositive end-expiratory pressureAcute lung injuryPostoperative lung infectionLung infectionLung ventilationLTV ventilationHospital stayHealthy patientsLow tidal volume mechanical ventilationPostoperative acute lung injuryIntermittent recruitment maneuverIntraoperative ventilation strategiesProtective lung ventilationLength of hospitalProtective ventilation strategyEnd-expiratory pressureVolume mechanical ventilationVentilation strategiesAnalysis of trialsPostoperative incidencePulmonary complicationsPulmonary outcomesProtective ventilationLung injuryRecruitment maneuvers