2009
CD27 is a thymic determinant of the balance between interferon-γ- and interleukin 17–producing γδ T cell subsets
Ribot JC, deBarros A, Pang DJ, Neves JF, Peperzak V, Roberts SJ, Girardi M, Borst J, Hayday AC, Pennington DJ, Silva-Santos B. CD27 is a thymic determinant of the balance between interferon-γ- and interleukin 17–producing γδ T cell subsets. Nature Immunology 2009, 10: 427-436. PMID: 19270712, PMCID: PMC4167721, DOI: 10.1038/ni.1717.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD27 LigandCells, CulturedInterferon-gammaInterleukin-17Lymphoid Progenitor CellsLymphotoxin beta ReceptorMalaria, CerebralMiceMice, Inbred C57BLPlasmodium bergheiReceptors, Antigen, T-Cell, gamma-deltaThymus GlandT-Lymphocyte SubsetsTumor Necrosis Factor Receptor Superfamily, Member 7
2003
γδ T Cells Provide an Early Source of Interferon γ in Tumor Immunity
Gao Y, Yang W, Pan M, Scully E, Girardi M, Augenlicht LH, Craft J, Yin Z. γδ T Cells Provide an Early Source of Interferon γ in Tumor Immunity. Journal Of Experimental Medicine 2003, 198: 433-442. PMID: 12900519, PMCID: PMC2194096, DOI: 10.1084/jem.20030584.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsImmunity, CellularInterferon-gammaInterleukin-12Lymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutNeoplasm TransplantationNeoplasms, ExperimentalReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaT-Lymphocyte SubsetsTransplantation ChimeraTumor Cells, CulturedConceptsGammadelta T cellsAlphabeta T cellsT cellsTumor immunityIFN-gammaHigh incidenceGammadelta T cell-deficient miceImpaired IFN-gamma productionT cell-deficient miceTumor developmentCell-deficient miceBone marrow chimerasΓδ T cellsIFN-gamma productionSite of tumorT cell repertoireWild-type miceChemical carcinogen methylcholanthreneMelanoma cell line B16B16 melanoma cellsTumor lysateCarcinogen methylcholanthreneTumor immunosurveillanceInterferon γSuch mice