2018
Pillars Article: Regulation of Cutaneous Malignancy by γδ T Cells. Science. 2001. 294: 605-609.
Girardi M, Oppenheim DE, Steele CR, Lewis JM, Glusac E, Filler R, Hobby P, Sutton B, Tigelaar RE, Hayday AC. Pillars Article: Regulation of Cutaneous Malignancy by γδ T Cells. Science. 2001. 294: 605-609. The Journal Of Immunology 2018, 200: 3031-3035. PMID: 29685949.Peer-Reviewed Original ResearchCommensal orthologs of the human autoantigen Ro60 as triggers of autoimmunity in lupus
Greiling TM, Dehner C, Chen X, Hughes K, Iñiguez AJ, Boccitto M, Ruiz DZ, Renfroe SC, Vieira SM, Ruff WE, Sim S, Kriegel C, Glanternik J, Chen X, Girardi M, Degnan P, Costenbader KH, Goodman AL, Wolin SL, Kriegel MA. Commensal orthologs of the human autoantigen Ro60 as triggers of autoimmunity in lupus. Science Translational Medicine 2018, 10 PMID: 29593104, PMCID: PMC5918293, DOI: 10.1126/scitranslmed.aan2306.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoantigensAutoimmunityCell ProliferationFemaleHumansLupus NephritisMaleMiceRibonucleoproteinsT-LymphocytesConceptsLupus patientsGlomerular immune complex depositsPositive lupus patientsImmune complex depositsGerm-free miceSigns of autoimmunityB cell responsesT cell clonesNovel treatment approachesTriggers of autoimmunityCommensal bacterial speciesEarliest autoantibodiesChronic autoimmunityAutoimmune diseasesHealthy controlsT cellsTreatment approachesSusceptible individualsAutoimmunityCell responsesCommensal speciesLupusPatientsCell clonesGut commensals
2012
Development of a Plaque Infiltrated With Large CD30+ T Cells Over a Silicone-Containing Device in a Patient With History of Sézary Syndrome
Engberg AK, Bunick CG, Subtil A, Ko CJ, Girardi M. Development of a Plaque Infiltrated With Large CD30+ T Cells Over a Silicone-Containing Device in a Patient With History of Sézary Syndrome. Journal Of Clinical Oncology 2012, 31: e87-e89. PMID: 23182990, PMCID: PMC4855504, DOI: 10.1200/jco.2012.42.9241.Peer-Reviewed Original ResearchLangerhans Cells Facilitate Epithelial DNA Damage and Squamous Cell Carcinoma
Modi BG, Neustadter J, Binda E, Lewis J, Filler RB, Roberts SJ, Kwong BY, Reddy S, Overton JD, Galan A, Tigelaar R, Cai L, Fu P, Shlomchik M, Kaplan DH, Hayday A, Girardi M. Langerhans Cells Facilitate Epithelial DNA Damage and Squamous Cell Carcinoma. Science 2012, 335: 104-108. PMID: 22223807, PMCID: PMC3753811, DOI: 10.1126/science.1211600.Peer-Reviewed Original ResearchMeSH Keywords9,10-Dimethyl-1,2-benzanthraceneAnimalsAryl Hydrocarbon HydroxylasesCarcinogensCarcinoma, Squamous CellCell Transformation, NeoplasticCells, CulturedCytochrome P-450 CYP1A1Cytochrome P-450 CYP1B1DNA DamageGenes, rasHumansKeratinocytesLangerhans CellsMiceMice, TransgenicSkin NeoplasmsT-LymphocytesConceptsLangerhans cellsDendritic cellsDMBA-induced DNA damageCutaneous chemical carcinogenesisEpidermal dendritic cellsLC-deficient miceT cell immunitySquamous cell carcinomaChemical carcinogenesisDMBA-transHras mutationsCell immunityCell carcinomaImmune cellsDNA damageTumor resistanceDMBAPrior incubationHuman keratinocytesCarcinogenesisUnderlying mechanismMicePotent carcinogenSkinPAH metabolism
2008
Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal γδ T cells
Boyden LM, Lewis JM, Barbee SD, Bas A, Girardi M, Hayday AC, Tigelaar RE, Lifton RP. Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal γδ T cells. Nature Genetics 2008, 40: 656-662. PMID: 18408721, PMCID: PMC4167720, DOI: 10.1038/ng.108.Peer-Reviewed Original ResearchAcute upregulation of an NKG2D ligand promotes rapid reorganization of a local immune compartment with pleiotropic effects on carcinogenesis
Strid J, Roberts SJ, Filler RB, Lewis JM, Kwong BY, Schpero W, Kaplan DH, Hayday AC, Girardi M. Acute upregulation of an NKG2D ligand promotes rapid reorganization of a local immune compartment with pleiotropic effects on carcinogenesis. Nature Immunology 2008, 9: 146-154. PMID: 18176566, DOI: 10.1038/ni1556.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Transformation, NeoplasticEpidermisHistocompatibility Antigens Class IImmunologic SurveillanceLangerhans CellsLigandsMiceMice, Inbred StrainsNK Cell Lectin-Like Receptor Subfamily KReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaReceptors, ImmunologicReceptors, Natural Killer CellSkin NeoplasmsT-LymphocytesUp-RegulationConceptsNKG2D ligandsImmune compartmentLangerhans cellsT cellsRAE-1Local immune compartmentIntraepithelial T cellsΑβ T cellsEpithelial infiltrationTissue immunosurveillanceGraft rejectionInflammatory lesionsReceptor NKG2DAcute changesLigand MICACytotoxic lymphocytesAcute upregulationImmunosurveillanceEarly phaseCarcinogenesisUpregulationPleiotropic effectsCellsNKG2DCarcinoma
2007
Cutaneous Perspectives on Adaptive Immunity
Girardi M. Cutaneous Perspectives on Adaptive Immunity. Clinical Reviews In Allergy & Immunology 2007, 33: 4-14. PMID: 18094943, DOI: 10.1007/s12016-007-0040-9.Peer-Reviewed Original ResearchConceptsAntigen-specific responsesAdaptive immunityAdaptive immune systemDendritic cellsEffector cellsImmunologic memoryTumor immunosurveillanceInflammatory diseasesT cellsImmune responseImmune systemMajor subsetEndothelial cellsSkinMicrobial defenseImmunocytesImmunityEfficient surveillanceCellsResponseImmunosurveillanceChemokinesCytokinesLymphocytesDamaging agents
2006
Environmentally Responsive and Reversible Regulation of Epidermal Barrier Function by γδ T Cells
Girardi M, Lewis JM, Filler RB, Hayday AC, Tigelaar RE. Environmentally Responsive and Reversible Regulation of Epidermal Barrier Function by γδ T Cells. Journal Of Investigative Dermatology 2006, 126: 808-814. PMID: 16439970, DOI: 10.1038/sj.jid.5700120.Peer-Reviewed Original ResearchConceptsDendritic epidermal T cellsT cellsGammadelta T cell-deficient miceLimited T cell receptor diversityT cell-deficient miceBarrier functionTCRdelta-/- miceT-cell receptor diversityEpidermal T cellsT cell compartmentΓδ T cellsBarrier function defectsEpidermal barrier functionTransepidermal water lossPathogen-specific antigensCutaneous inflammationCutaneous neoplasiaDeficient miceGammadelta cellsFunction defectsCutaneous physiologyFetal thymocytesEpidermal barrierHydration statusReceptor diversityImmunosurveillance and Immunoregulation by γδ T Cells
Girardi M. Immunosurveillance and Immunoregulation by γδ T Cells. Journal Of Investigative Dermatology 2006, 126: 25-31. PMID: 16417214, DOI: 10.1038/sj.jid.5700003.Peer-Reviewed Original ResearchConceptsGammadelta T cellsT cell receptorT cellsGammadelta T-cell receptorΓδ T cellsCellular stressHuman diseasesAlphabeta heterodimersTCR diversityCutaneous functionImmunoregulatory activitySmall populationMutant miceEpithelial surfaceCellsHeterodimersVast majorityDiversityImmunosurveillanceImmunoregulation
2005
Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance
Oppenheim DE, Roberts SJ, Clarke SL, Filler R, Lewis JM, Tigelaar RE, Girardi M, Hayday AC. Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance. Nature Immunology 2005, 6: 928-937. PMID: 16116470, DOI: 10.1038/ni1239.Peer-Reviewed Original ResearchMeSH Keywords9,10-Dimethyl-1,2-benzanthraceneAnimalsCarcinomaCell Line, TumorDisease SusceptibilityDown-RegulationFemaleImmunologic SurveillanceKiller Cells, NaturalLigandsMaleMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicNK Cell Lectin-Like Receptor Subfamily KPapillomaReceptors, ImmunologicReceptors, Natural Killer CellSkin NeoplasmsTetradecanoylphorbol AcetateT-LymphocytesTumor BurdenConceptsNKG2D downregulationNK cell-mediated cytotoxicityNatural killer cellsCell-mediated cytotoxicityInnate immune activationT cell defectsNKG2D engagementNatural cytotoxicityKiller cellsImmune activationReceptor NKG2DTumor immunosurveillanceCutaneous carcinogenesisTumor surveillanceT cellsReversible defectsRAE-1Normal epitheliumLigand expressionTumor resistanceCell defectsSustained expressionNKG2DImmunosurveillanceDownregulationCross-Comparison of Patch Test and Lymphocyte Proliferation Responses in Patients With a History of Acute Generalized Exanthematous Pustulosis
Girardi M, Duncan KO, Tigelaar RE, Imaeda S, Watsky KL, McNiff JM. Cross-Comparison of Patch Test and Lymphocyte Proliferation Responses in Patients With a History of Acute Generalized Exanthematous Pustulosis. American Journal Of Dermatopathology 2005, 27: 343-346. PMID: 16121058, DOI: 10.1097/01.dad.0000160982.75176.6c.Peer-Reviewed Original ResearchConceptsAcute generalized exanthematous pustulosisPatch test resultsPositive patch test resultsGeneralized exanthematous pustulosisLymphocyte proliferative responsesProliferative responseExanthematous pustulosisPeripheral T-cell proliferative responsesT cell-mediated immune responsesDrug-specific T cellsVitro lymphocyte proliferative responseCalcium channel blocker diltiazemCell-mediated immune responsesDelayed-type hypersensitivity reactionT cell proliferative responsesAdverse cutaneous reactionsLymphocyte proliferation responseChannel blocker diltiazemCell proliferative responsesPatch test sitesNeutrophilic pustulesClinical responsePerivascular lymphocytesCutaneous reactionsHypersensitivity reactions
2004
The Pathogenesis of Mycosis Fungoides
Girardi M, Heald PW, Wilson LD. The Pathogenesis of Mycosis Fungoides. New England Journal Of Medicine 2004, 350: 1978-1988. PMID: 15128898, DOI: 10.1056/nejmra032810.Peer-Reviewed Original ResearchCharacterizing the Protective Component of the αβ T Cell Response to Transplantable Squamous Cell Carcinoma
Girardi M, Oppenheim D, Glusac EJ, Filler R, Balmain A, Tigelaar RE, Hayday AC. Characterizing the Protective Component of the αβ T Cell Response to Transplantable Squamous Cell Carcinoma. Journal Of Investigative Dermatology 2004, 122: 699-706. PMID: 15086556, DOI: 10.1111/j.0022-202x.2004.22342.x.Peer-Reviewed Original ResearchConceptsT cell responsesImmune responseCell responsesProtective anti-tumor effectTransplantable squamous cell carcinomaT cell-deficient miceAlphabeta T cell responsesCell-deficient miceT cell activityCellular immune responsesSquamous cell carcinomaΑβ T cell responsesSquamous cell carcinoma linesAlphabeta T cellsAnti-tumor effectsNK receptorsCell carcinomaT cellsFocal necrosesRAE-1Protective potentialTumor growthProtective responseStromal bedCell activityCutaneous biology of gammadelta T cells.
Girardi M. Cutaneous biology of gammadelta T cells. Advances In Dermatology 2004, 20: 203-15. PMID: 15544201.Peer-Reviewed Original ResearchConceptsGammadelta T cellsT cellsInappropriate inflammatory responseNoninfectious skin diseasesMajor disease categoriesMost T cellsCutaneous inflammationLymph nodesCutaneous neoplasmsCutaneous tumorsCutaneous diseaseInflammatory responseReceptor subtypesSkin diseasesDisease categoriesEpidermal barrierCutaneous biologyInflammationLaboratory animalsNeoplastic transformationTCR variabilityDiseaseEpithelial tissuesCellsRecent studies
2003
The Distinct Contributions of Murine T Cell Receptor (TCR)γδ+ and TCRαβ+ T Cells to Different Stages of Chemically Induced Skin Cancer
Girardi M, Glusac E, Filler RB, Roberts SJ, Propperova I, Lewis J, Tigelaar RE, Hayday AC. The Distinct Contributions of Murine T Cell Receptor (TCR)γδ+ and TCRαβ+ T Cells to Different Stages of Chemically Induced Skin Cancer. Journal Of Experimental Medicine 2003, 198: 747-755. PMID: 12953094, PMCID: PMC2194182, DOI: 10.1084/jem.20021282.Peer-Reviewed Original ResearchMeSH Keywords9,10-Dimethyl-1,2-benzanthraceneAnimalsCarcinogensDisease Models, AnimalHematopoietic Stem CellsLiverMiceMice, KnockoutNeoplasm StagingPapillomaReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaSkin NeoplasmsTetradecanoylphorbol AcetateTime FactorsT-LymphocytesConceptsAlphabeta T cellsT cellsT cell receptorGammadelta cellsCell receptorProgression of papillomasResident intraepithelial lymphocytesSquamous cell carcinomaT-cell typeTwo-stage regimenMurine T cell receptorInduction of papillomasIntraepithelial lymphocytesCutaneous malignanciesCell carcinomaFVB miceHost protectionSkin cancerLow dosesCarcinomaPapillomasTumor promoterNonredundant contributionsModifier genesProgression
2002
Resident Skin-specific γδ T Cells Provide Local, Nonredundant Regulation of Cutaneous Inflammation
Girardi M, Lewis J, Glusac E, Filler RB, Geng L, Hayday AC, Tigelaar RE. Resident Skin-specific γδ T Cells Provide Local, Nonredundant Regulation of Cutaneous Inflammation. Journal Of Experimental Medicine 2002, 195: 855-867. PMID: 11927630, PMCID: PMC2193718, DOI: 10.1084/jem.20012000.Peer-Reviewed Original ResearchConceptsT cell receptorEpidermal T cellsT cellsIrritant dermatitisGammadelta T-cell receptorT cell-mediated inflammationCell-mediated inflammationSystemic inflammatory reactionIrritant contact dermatitis reactionsΓδ T cellsGammadelta T cellsContact dermatitis reactionsCutaneous inflammationIEL subsetsChronic dermatitisFunctional impairmentInflammatory reactionDermatitis reactionsEpithelial interfaceCell subpopulationsCell receptorMiceMouse strainsDermatitisSingle autosomal recessive gene
2000
Cutaneous T-cell lymphoma: pathogenesis and treatment.
Girardi M, Edelson RL. Cutaneous T-cell lymphoma: pathogenesis and treatment. Oncology 2000, 14: 1061-70; discussion 1070-4, 1076. PMID: 10929591.Peer-Reviewed Original ResearchConceptsCutaneous T-cell lymphomaSkin immune systemImmune systemT cellsManagement of CTCLCutaneous T-cellMemory T cellsT helper cellsT-cell lymphomaSelective adhesion moleculeLymph nodesClinical spectrumPeripheral bloodCutaneous pathogensMajor subtypesPathogenesisAdhesion moleculesLymphomaDistinctive subsetTreatmentNormal functioningCellsBetter understandingImmunosurveillanceMalignancy
1995
Specific Suppression of Lupus-Like Graft-Versus-Host Disease Using Extracorporeal Photochemical Attenuation of Effector Lymphocytes
Girardi M, Herreid P, Tigelaar R. Specific Suppression of Lupus-Like Graft-Versus-Host Disease Using Extracorporeal Photochemical Attenuation of Effector Lymphocytes. Journal Of Investigative Dermatology 1995, 104: 177-182. PMID: 7829872, DOI: 10.1111/1523-1747.ep12612741.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, AntinuclearAscitesAutoimmune DiseasesDisease Models, AnimalFemaleGlomerulonephritisGraft vs Host DiseaseGraft vs Host ReactionImmunotherapy, AdoptiveKidneyLupus Erythematosus, SystemicMiceMice, Inbred C3HMice, Inbred C57BLMice, Inbred DBAPUVA TherapyT-LymphocytesVaccinationConceptsSystemic lupus erythematosus-like diseaseB6D2F1 recipientsDisease initiationD2 cellsAntinuclear antibody titerLupus-like graftProgression of graftVersus Host DiseaseSystemic lupus erythematosusC3H/HeJ xDBA/2 splenocytesHost diseaseLupus erythematosusEffector lymphocytesClinical manifestationsClinical parametersHistologic evidenceAntibody titersKidney diseaseAscites formationB6D2F1 miceInterleukin-2T cellsC57BL/6 xComplex antigens