2024
Generation and optimization of off-the-shelf immunotherapeutics targeting TCR-Vβ2+ T cell malignancy
Ren J, Liao X, Lewis J, Chang J, Qu R, Carlson K, Foss F, Girardi M. Generation and optimization of off-the-shelf immunotherapeutics targeting TCR-Vβ2+ T cell malignancy. Nature Communications 2024, 15: 519. PMID: 38225288, PMCID: PMC10789731, DOI: 10.1038/s41467-024-44786-2.Peer-Reviewed Original ResearchMeSH KeywordsClone CellsHumansImmunotherapy, AdoptiveJurkat CellsReceptors, Antigen, T-CellReceptors, Chimeric AntigenConceptsAntibody-dependent cellular cytotoxicityDonor T cellsT cellsAdeno-associated virus transductionHealthy donor T cellsHost-versus-graft reactivityEnhanced antibody-dependent cellular cytotoxicityCAR-T cellsGraft-versus-hostT cell killingT-cell malignanciesMalignant T cellsNormal T-cellT cell receptorOff-target toxicityPre-existing immunoreactivityCAR-TDisease relapseCellular cytotoxicityVirus transductionCurrent treatmentPersister killingFc engineeringB2MIn vivo
2023
Integrated transcriptome and trajectory analysis of cutaneous T-cell lymphoma identifies putative precancer populations
Ren J, Qu R, Rahman N, Lewis J, King A, Liao X, Mirza F, Carlson K, Huang Y, Gigante S, Evans B, Rajendran B, Xu S, Wang G, Foss F, Damsky W, Kluger Y, Krishnaswamy S, Girardi M. Integrated transcriptome and trajectory analysis of cutaneous T-cell lymphoma identifies putative precancer populations. Blood Advances 2023, 7: 445-457. PMID: 35947128, PMCID: PMC9979716, DOI: 10.1182/bloodadvances.2022008168.Peer-Reviewed Original ResearchMeSH KeywordsCD4-Positive T-LymphocytesHumansLymphoma, T-Cell, CutaneousReceptors, Antigen, T-CellSkin NeoplasmsTranscriptomeConceptsCutaneous T-cell lymphomaMalignant CTCL cellsDiverse transcriptomic profilesT cellsSingle-cell RNACTCL cellsDevelopment of CTCLIntegrated transcriptomeT-cell receptor sequencingT cell exhaustion phenotypeCommon antigenic stimulusPeripheral blood CD4Transcriptomic profilesGene expressionT-cell lymphomaIntegrative analysisPotential therapeutic targetProliferation advantageLimited diversityBlood CD4Blood involvementMutation levelsExhaustion phenotypeWorse prognosisAntigenic stimulus
2016
Cutaneous T-cell lymphoma (CTCL): Current practices in blood assessment and the utility of T-cell receptor (TCR)-Vβ chain restriction
Gibson JF, Huang J, Liu KJ, Carlson KR, Foss F, Choi J, Edelson R, Hussong JW, Mohl R, Hill S, Girardi M. Cutaneous T-cell lymphoma (CTCL): Current practices in blood assessment and the utility of T-cell receptor (TCR)-Vβ chain restriction. Journal Of The American Academy Of Dermatology 2016, 74: 870-877. PMID: 26874819, PMCID: PMC4835257, DOI: 10.1016/j.jaad.2015.12.018.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCross-Sectional StudiesFemaleFlow CytometryHematologic TestsHumansInternationalityLymphoma, T-Cell, CutaneousMaleMiddle AgedMycosis FungoidesNeoplasm InvasivenessNeoplasm StagingPolymerase Chain ReactionPractice Guidelines as TopicPredictive Value of TestsPrognosisRare DiseasesReceptors, Antigen, T-CellRetrospective StudiesSezary SyndromeSkin NeoplasmsSocieties, MedicalConceptsCutaneous T-cell lymphomaT-cell lymphomaCurrent clinical practiceClinical practicePredictive valueNegative predictive valuePositive predictive valueCurrent International SocietyT cell receptorImmunophenotypic abnormalitiesEvidence of clonalitySingle centerTumor burdenBlood assessmentClinical benefitPeripheral bloodCohort casesDisease burdenPolymerase chain reactionStaging criteriaChain restrictionRetrospective analysisMalignant cellsFlow cytometryDiagnostic algorithm
2015
The difficult—and often delayed—diagnosis of CTCL
Weed J, Girardi M. The difficult—and often delayed—diagnosis of CTCL. Science Translational Medicine 2015, 7: 308fs41. PMID: 26446952, DOI: 10.1126/scitranslmed.aad2518.Peer-Reviewed Original Research
2007
Cutaneous Perspectives on Adaptive Immunity
Girardi M. Cutaneous Perspectives on Adaptive Immunity. Clinical Reviews In Allergy & Immunology 2007, 33: 4-14. PMID: 18094943, DOI: 10.1007/s12016-007-0040-9.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen PresentationB-LymphocytesCell DifferentiationCytokinesHumansImmune ToleranceImmunityLymphocyte ActivationReceptors, Antigen, T-CellSkinT-LymphocytesToll-Like ReceptorsConceptsAntigen-specific responsesAdaptive immunityAdaptive immune systemDendritic cellsEffector cellsImmunologic memoryTumor immunosurveillanceInflammatory diseasesT cellsImmune responseImmune systemMajor subsetEndothelial cellsSkinMicrobial defenseImmunocytesImmunityEfficient surveillanceCellsResponseImmunosurveillanceChemokinesCytokinesLymphocytesDamaging agents
2001
The Clonotypic T Cell Receptor Is a Source of Tumor‐associated Antigens in Cutaneous T Cell Lymphoma
BERGER C, LONGLEY J, HANLON D, GIRARDI M, EDELSON R. The Clonotypic T Cell Receptor Is a Source of Tumor‐associated Antigens in Cutaneous T Cell Lymphoma. Annals Of The New York Academy Of Sciences 2001, 941: 106-122. PMID: 11594564, DOI: 10.1111/j.1749-6632.2001.tb03715.x.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntigens, NeoplasmCancer VaccinesCD8-Positive T-LymphocytesCell LineCells, CulturedHumansHybridomasImmunoglobulin IdiotypesLymphocyte ActivationLymphoma, T-Cell, CutaneousMiceNeoplasm TransplantationPeptidesReceptors, Antigen, T-CellSkin NeoplasmsSurvival RateT-Lymphocytes, CytotoxicTransfectionConceptsCutaneous T-cell lymphomaT-cell lymphomaT cell receptorClonotypic T cell receptorCell lymphomaAutologous CD8 T cellsCD8 T cell linesCell receptorBeta chainCD8 T cell recognitionImmunogenic tumor peptidesCD8 T cellsCell surface TCR expressionClass I MHC moleculesSource of tumorsT cell recognitionT-cell malignanciesTCR beta chainI MHC moleculesT cell linesTCR epitopesTumor epitopesDendritic cellsSurface TCR expressionCancer vaccines