2015
Langerhans Cells Facilitate UVB-Induced Epidermal Carcinogenesis
Lewis JM, Bürgler CD, Freudzon M, Golubets K, Gibson JF, Filler RB, Girardi M. Langerhans Cells Facilitate UVB-Induced Epidermal Carcinogenesis. Journal Of Investigative Dermatology 2015, 135: 2824-2833. PMID: 26053049, PMCID: PMC4640962, DOI: 10.1038/jid.2015.207.Peer-Reviewed Original ResearchConceptsLangerhans cellsGroup 3 innate lymphoid cellsAbsence of LCsRole of LCsSquamous cell carcinoma formationInnate lymphoid cellsUVB-induced carcinogenesisInnate immune cellsAcute UVB exposureT-cell independentTumor suppressor gene p53IL-22Cutaneous carcinogenesisImmune cellsTumor outgrowthKC populationLymphoid cellsChronic exposureKC proliferationUVB exposureCarcinoma formationClonal expansionEpidermal carcinogenesisGene p53Carcinogenesis
2012
Langerhans Cells Facilitate Epithelial DNA Damage and Squamous Cell Carcinoma
Modi BG, Neustadter J, Binda E, Lewis J, Filler RB, Roberts SJ, Kwong BY, Reddy S, Overton JD, Galan A, Tigelaar R, Cai L, Fu P, Shlomchik M, Kaplan DH, Hayday A, Girardi M. Langerhans Cells Facilitate Epithelial DNA Damage and Squamous Cell Carcinoma. Science 2012, 335: 104-108. PMID: 22223807, PMCID: PMC3753811, DOI: 10.1126/science.1211600.Peer-Reviewed Original ResearchMeSH Keywords9,10-Dimethyl-1,2-benzanthraceneAnimalsAryl Hydrocarbon HydroxylasesCarcinogensCarcinoma, Squamous CellCell Transformation, NeoplasticCells, CulturedCytochrome P-450 CYP1A1Cytochrome P-450 CYP1B1DNA DamageGenes, rasHumansKeratinocytesLangerhans CellsMiceMice, TransgenicSkin NeoplasmsT-LymphocytesConceptsLangerhans cellsDendritic cellsDMBA-induced DNA damageCutaneous chemical carcinogenesisEpidermal dendritic cellsLC-deficient miceT cell immunitySquamous cell carcinomaChemical carcinogenesisDMBA-transHras mutationsCell immunityCell carcinomaImmune cellsDNA damageTumor resistanceDMBAPrior incubationHuman keratinocytesCarcinogenesisUnderlying mechanismMicePotent carcinogenSkinPAH metabolism