2022
LB998 Lymph node delivery of immunstimulatory agent monophosphoryl lipid A via bioadhesive nanoparticles in the treatment of cutaneous melanoma
Chang J, Shin K, Lewis J, Suh H, Bosenberg M, Saltzman W, Girardi M. LB998 Lymph node delivery of immunstimulatory agent monophosphoryl lipid A via bioadhesive nanoparticles in the treatment of cutaneous melanoma. Journal Of Investigative Dermatology 2022, 142: b29. DOI: 10.1016/j.jid.2022.05.1024.Peer-Reviewed Original ResearchTopical formulation based on disease-specific nanoparticles for single-dose cure of psoriasis
Mai Y, Ouyang Y, Yu M, Qin Y, Girardi M, Saltzman WM, Cocco E, Zhao C, Yu L, Jia Y, Xiao L, Dou L, Deng W, Liu Y, Xie J, Deng Y. Topical formulation based on disease-specific nanoparticles for single-dose cure of psoriasis. Journal Of Controlled Release 2022, 349: 354-366. PMID: 35817278, DOI: 10.1016/j.jconrel.2022.07.006.Peer-Reviewed Original ResearchConceptsHealthy skinPsoriasis treatmentTopical formulationsPsoriatic skinCurrent psoriasis treatmentsFirst-line treatmentSingle-dose cureLocal drug concentrationModerate psoriasisLesional skinSingle doseDermal atrophyTherapeutic levelsTherapeutic efficacyCorticosteroidsDrug concentrationsPsoriasisBNPBasal cellsSkin retentionSkinLesionsBioadhesive nanoparticlesTreatmentStratum corneum
2015
A sunblock based on bioadhesive nanoparticles
Deng Y, Ediriwickrema A, Yang F, Lewis J, Girardi M, Saltzman WM. A sunblock based on bioadhesive nanoparticles. Nature Materials 2015, 14: 1278-1285. PMID: 26413985, PMCID: PMC4654636, DOI: 10.1038/nmat4422.Peer-Reviewed Original ResearchConceptsBioadhesive nanoparticlesCommercial sunscreen formulationsInorganic ultraviolet (UV) filtersUV filtersCellular exposureCutaneous phototoxicityMurine modelFollicular penetrationHealth concernNanoparticlesUV filter concentrationsTowel dryingPadimate OUV protectionSunblockSunscreen formulationsStratum corneumUltraviolet filtersExposureFilter