A transient epidermolysis bullosa simplex‐like phenotype associated with bexarotene treatment in a G138E KRT5 heterozygote
Trufant JW, Kreizenbeck GM, Carlson KR, Muthusamy V, Girardi M, Bosenberg MW. A transient epidermolysis bullosa simplex‐like phenotype associated with bexarotene treatment in a G138E KRT5 heterozygote. Journal Of Cutaneous Pathology 2010, 37: 1155-1160. PMID: 20849457, DOI: 10.1111/j.1600-0560.2010.01557.x.Peer-Reviewed Original ResearchConceptsBexarotene treatmentEpidermolysis bullosa simplexKeratinocyte lysisCutaneous T-cell lymphomaT-cell lymphomaPalmoplantar keratodermaIntraepidermal blister formationClinical subtypesClinical trialsDrug treatmentSide effectsMechanobullous disordersReticulate hyperpigmentationSkin fragilityLike phenotypeKeratin 5Genetic sequencingSimilar frequencyRare variantsFocal palmoplantar keratodermaBlister formationTreatmentKRT5 mutationKeratin synthesisKeratoderma