2015
Quantifying hyperoxia-mediated damage to mammalian respiratory cilia-driven fluid flow using particle tracking velocimetry optical coherence tomography
Gamm UA, Huang BK, Syed M, Zhang X, Bhandari V, Choma MA. Quantifying hyperoxia-mediated damage to mammalian respiratory cilia-driven fluid flow using particle tracking velocimetry optical coherence tomography. Journal Of Biomedical Optics 2015, 20: 080505-080505. PMID: 26308164, PMCID: PMC4874052, DOI: 10.1117/1.jbo.20.8.080505.Peer-Reviewed Original ResearchConceptsOptical coherence tomographyMouse tracheaCoherence tomographyDrug-mediated modulationIntensive care unitRisk-benefit profileRespiratory failureCare unitOxygen supplementationRespiratory mucosaRespiratory epitheliumIndispensable treatmentImpaired capacityClinical useHyperoxiaTracheaFlow quantificationTomographyTreatmentDamagePatientsMucosaSupplementationEpitheliumQuantitative optical coherence tomography imaging of intermediate flow defect phenotypes in ciliary physiology and pathophysiology
Huang BK, Gamm UA, Jonas S, Khokha MK, Choma MA. Quantitative optical coherence tomography imaging of intermediate flow defect phenotypes in ciliary physiology and pathophysiology. Journal Of Biomedical Optics 2015, 20: 030502-030502. PMID: 25751026, PMCID: PMC4352652, DOI: 10.1117/1.jbo.20.3.030502.Peer-Reviewed Original Research
2014
Microscale imaging of cilia-driven fluid flow
Huang BK, Choma MA. Microscale imaging of cilia-driven fluid flow. Cellular And Molecular Life Sciences 2014, 72: 1095-1113. PMID: 25417211, PMCID: PMC4605231, DOI: 10.1007/s00018-014-1784-z.Peer-Reviewed Original Research
2013
A novel approach to quantifying ciliary physiology: microfluidic mixing driven by a ciliated biological surface
Jonas S, Zhou E, Deniz E, Huang B, Chandrasekera K, Bhattacharya D, Wu Y, Fan R, Deserno TM, Khokha MK, Choma MA. A novel approach to quantifying ciliary physiology: microfluidic mixing driven by a ciliated biological surface. Lab On A Chip 2013, 13: 4160-4163. PMID: 23970350, PMCID: PMC3856250, DOI: 10.1039/c3lc50571e.Peer-Reviewed Original Research
2012
Endogenous contrast blood flow imaging in embryonic hearts using hemoglobin contrast subtraction angiography.
Deniz E, Jonas S, Khokha M, Choma MA. Endogenous contrast blood flow imaging in embryonic hearts using hemoglobin contrast subtraction angiography. Optics Letters 2012, 37: 2979-81. PMID: 22825198, PMCID: PMC3881542, DOI: 10.1364/ol.37.002979.Peer-Reviewed Original ResearchConceptsCongenital heart diseaseBiomechanical phenotypingSmall animal modelsMicroangiography techniqueCardiac dysfunctionEmbryonic heartHeart diseaseCardiac performanceEndogenous hemoglobin contrastContrast angiographyBlood flowCardioactive drugsAnimal modelsSubtraction angiographyVivo assessmentFunctional optical imagingHemoglobin contrastMalformed heartsAngiographyFlow imagingHeartPhysiological responsesImagingDysfunctionPhenotyping
2010
Physiological homology between Drosophila melanogaster and vertebrate cardiovascular systems
Choma MA, Suter MJ, Vakoc BJ, Bouma BE, Tearney GJ. Physiological homology between Drosophila melanogaster and vertebrate cardiovascular systems. Disease Models & Mechanisms 2010, 4: 411-420. PMID: 21183476, PMCID: PMC3097462, DOI: 10.1242/dmm.005231.Peer-Reviewed Original Research
2005
Spectral-domain phase microscopy.
Choma MA, Ellerbee AK, Yang C, Creazzo TL, Izatt JA. Spectral-domain phase microscopy. Optics Letters 2005, 30: 1162-4. PMID: 15945141, DOI: 10.1364/ol.30.001162.Peer-Reviewed Original ResearchConceptsSpectral domain phase microscopyShot-noise limitPhase-sensitive techniqueNanometer-scale motionCoherence gatingBroadband interferometryDisplacement sensitivityPhase microscopyPhase informationOptical coherence tomographyCoherence tomographyFunctional extensionAttractive techniqueInterferometryLiving cellsCellular motionMotionCellular dynamicsMicroscopyMeasurementsTechniqueGating